Disrupted interactions among the hippocampal, dorsal attention, and central-executive networks in amnestic mild cognitive impairment.


:Neuroimaging investigations consistently demonstrate that the neural processes involve complex interactions between the large-scale networks. Among those networks, the dorsal attention network (DAN) and the central-executive network (CEN) have been previously shown to exhibit anti-correlated activity with the default-mode network (DMN) in cognitively normal people. In amnestic mild cognitive impairment (MCI) and Alzheimer's disease, the hippocampal network (HCN)-a key memory processing system-and its interactions with other networks have gathered central interest. The current study aims to evaluate the patterns of functional architectures of the HCN with the three networks-DAN, CEN, and DMN-in amnestic MCI and normal controls (NC) to test the hypothesis that the interactions of HCN with other networks alter in MCI. We recorded the resting state functional MRI, assessed patterns of functional architectures between the four networks using dynamical causal modeling, and compared between NC and MCI. Our analysis showed that the DAN modulates the activity between the HCN and the DMN in both MCI and NC. We further uncovered that the DAN modulates the activity between the HCN and the CEN in NC, but such modulation is impaired in MCI. We found an association between impaired modulation and Montreal cognitive assessment (R = 0.349). Overall, our findings provide important insight in understanding the neuroimaging signature of amnestic MCI and/or Alzheimer's disease.


Hum Brain Mapp


Human brain mapping


Chand GB,Hajjar I,Qiu D




Has Abstract


2018-12-01 00:00:00












  • Pain anticipation: an activation likelihood estimation meta-analysis of brain imaging studies.

    abstract::The anticipation of pain has been investigated in a variety of brain imaging studies. Importantly, today there is no clear overall picture of the areas that are involved in different studies and the exact role of these regions in pain expectation remains especially unexploited. To address this issue, we used activatio...

    journal_title:Human brain mapping

    pub_type: 杂志文章,meta分析


    authors: Palermo S,Benedetti F,Costa T,Amanzio M

    更新日期:2015-05-01 00:00:00

  • Oscillations, networks, and their development: MEG connectivity changes with age.

    abstract::Magnetoencephalographic (MEG) investigations of inter-regional amplitude correlations have yielded new insights into the organization and neurophysiology of resting-state networks (RSNs) first identified using fMRI. Inter-regional MEG amplitude correlations in adult RSNs have been shown to be most prominent in alpha a...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Schäfer CB,Morgan BR,Ye AX,Taylor MJ,Doesburg SM

    更新日期:2014-10-01 00:00:00

  • 3D tract-specific local and global analysis of white matter integrity in Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by progressive decline in memory and other aspects of cognitive function. Diffusion-weighted imaging (DWI) offers a non-invasive approach to delineate the effects of AD on white matter (WM) integrity. Previous studies calculated either some ...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Jin Y,Huang C,Daianu M,Zhan L,Dennis EL,Reid RI,Jack CR Jr,Zhu H,Thompson PM,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2017-03-01 00:00:00

  • Reconstruction of extended cortical sources for EEG and MEG based on a Monte-Carlo-Markov-chain estimator.

    abstract::A new procedure to model extended cortical sources from EEG and MEG recordings based on a probabilistic approach is presented. The method (SPMECS) was implemented within the framework of maximum likelihood estimators. Neuronal activity generating EEG or MEG signals was characterized by the number of sources and their ...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Kincses WE,Braun C,Kaiser S,Grodd W,Ackermann H,Mathiak K

    更新日期:2003-02-01 00:00:00

  • Detecting bilateral abnormalities with voxel-based morphometry.

    abstract::In this article we describe a new method, using SPM99, that searches explicitly for bilateral structural abnormalities. Children with bilateral pathology have a poorer prognosis than children with unilateral damage. After brain injury or disease in childhood, it is thought that rescue of function is only possible if t...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Salmond CH,Ashburner J,Vargha-Khadem F,Gadian DG,Friston KJ

    更新日期:2000-11-01 00:00:00

  • Dynamic regional phase synchrony (DRePS): An Instantaneous Measure of Local fMRI Connectivity Within Spatially Clustered Brain Areas.

    abstract::Dynamic functional brain connectivity analysis is a fast expanding field in computational neuroscience research with the promise of elucidating brain network interactions. Sliding temporal window based approaches are commonly used in order to explore dynamic behavior of brain networks in task-free functional magnetic ...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Omidvarnia A,Pedersen M,Walz JM,Vaughan DN,Abbott DF,Jackson GD

    更新日期:2016-05-01 00:00:00

  • Internal representations for face detection: an application of noise-based image classification to BOLD responses.

    abstract::What basic visual structures underlie human face detection and how can we extract such structures directly from the amplitude of neural responses elicited by face processing? Here, we address these issues by investigating an extension of noise-based image classification to BOLD responses recorded in high-level visual ...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Nestor A,Vettel JM,Tarr MJ

    更新日期:2013-11-01 00:00:00

  • Transient perturbation of the left temporal cortex evokes plasticity-related reconfiguration of the lexical network.

    abstract::While much progress has been made in how brain organization supports language function, the language network's ability to adapt to immediate disturbances by means of reorganization remains unclear. The aim of this study was to examine acute reorganizational changes in brain activity related to conceptual and lexical r...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Klaus J,Schutter DJLG,Piai V

    更新日期:2020-03-01 00:00:00

  • Regional brain activity when selecting a response despite interference: An H2 (15) O PET study of the stroop and an emotional stroop.

    abstract::The Stroop interference test requires a person to respond to specific elements of a stimulus while suppressing a competing response. Previous positron emission tomography (PET) work has shown increased activity in the right anterior cingulate gyrus during the Stroop test. It is unclear, however, whether the anterior c...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: George MS,Ketter TA,Parekh PI,Rosinsky N,Ring H,Casey BJ,Trimble MR,Horwitz B,Herscovitch P,Post RM

    更新日期:1994-01-01 00:00:00

  • Population neuroscience: why and how.

    abstract::Population neuroscience endeavours to identify environmental and genetic factors that shape the function and structure of the human brain; it uses tools and knowledge of genetics, epidemiology, and cognitive neuroscience. Here, I focus on the application of population neuroscience in studies of brain development. By d...

    journal_title:Human brain mapping

    pub_type: 杂志文章,评审


    authors: Paus T

    更新日期:2010-06-01 00:00:00

  • Voxelwise and skeleton-based region of interest analysis of fetal alcohol syndrome and fetal alcohol spectrum disorders in young adults.

    abstract::Though fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders are among the most common developmental disorders, their understanding is incomplete. Diffusion tensor imaging (DTI), which is sensitive to microstructural organization in white matter, may provide a relevant measure in this population demonstrat...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Li L,Coles CD,Lynch ME,Hu X

    更新日期:2009-10-01 00:00:00

  • Correspondence between evoked and intrinsic functional brain network configurations.

    abstract::Much of the literature exploring differences between intrinsic and task-evoked brain architectures has examined changes in functional connectivity patterns between specific brain regions. While informative, this approach overlooks important overall functional changes in hub organization and network topology that may p...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Bolt T,Nomi JS,Rubinov M,Uddin LQ

    更新日期:2017-04-01 00:00:00

  • Mapping reliability in multicenter MRI: voxel-based morphometry and cortical thickness.

    abstract::Multicenter structural MRI studies can have greater statistical power than single-center studies. However, across-center differences in contrast sensitivity, spatial uniformity, etc., may lead to tissue classification or image registration differences that could reduce or wholly offset the enhanced statistical power o...

    journal_title:Human brain mapping

    pub_type: 杂志文章,多中心研究


    authors: Schnack HG,van Haren NE,Brouwer RM,van Baal GC,Picchioni M,Weisbrod M,Sauer H,Cannon TD,Huttunen M,Lepage C,Collins DL,Evans A,Murray RM,Kahn RS,Hulshoff Pol HE

    更新日期:2010-12-01 00:00:00

  • Network abnormalities among non-manifesting Parkinson disease related LRRK2 mutation carriers.

    abstract::Non-manifesting carriers (NMC) of the G2019S mutation in the LRRK2 gene represent an "at risk" group for future development of Parkinson's disease (PD) and have demonstrated task related fMRI changes. However, resting-state networks have received less research focus, thus this study aimed to assess the integrity of th...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Jacob Y,Rosenberg-Katz K,Gurevich T,Helmich RC,Bloem BR,Orr-Urtreger A,Giladi N,Mirelman A,Hendler T,Thaler A

    更新日期:2019-06-01 00:00:00

  • Grammatical analysis as a distributed neurobiological function.

    abstract::Language processing engages large-scale functional networks in both hemispheres. Although it is widely accepted that left perisylvian regions have a key role in supporting complex grammatical computations, patient data suggest that some aspects of grammatical processing could be supported bilaterally. We investigated ...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Bozic M,Fonteneau E,Su L,Marslen-Wilson WD

    更新日期:2015-03-01 00:00:00

  • Probabilistic fiber tracking using the residual bootstrap with constrained spherical deconvolution.

    abstract::Constrained spherical deconvolution (CSD) is a new technique that, based on high-angular resolution diffusion imaging (HARDI) MR data, estimates the orientation of multiple intravoxel fiber populations within regions of complex white matter architecture, thereby overcoming the limitations of the widely used diffusion ...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Jeurissen B,Leemans A,Jones DK,Tournier JD,Sijbers J

    更新日期:2011-03-01 00:00:00

  • Genetic influences on resting-state functional networks: A twin study.

    abstract::Alterations in resting-state networks (RSNs) are often associated with psychiatric and neurologic disorders. Given this critical linkage, it has been hypothesized that RSNs can potentially be used as endophenotypes for brain diseases. To validate this notion, a critical step is to show that RSNs exhibit heritability. ...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Fu Y,Ma Z,Hamilton C,Liang Z,Hou X,Ma X,Hu X,He Q,Deng W,Wang Y,Zhao L,Meng H,Li T,Zhang N

    更新日期:2015-10-01 00:00:00

  • Single-subject independent component analysis-based intensity normalization in non-quantitative multi-modal structural MRI.

    abstract::Non-quantitative MRI is prone to intersubject intensity variation rendering signal intensity level based analyses limited. Here, we propose a method that fuses non-quantitative routine T1-weighted (T1w), T2w, and T2w fluid-saturated inversion recovery sequences using independent component analysis and validate it on a...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Papazoglou S,Würfel J,Paul F,Brandt AU,Scheel M

    更新日期:2017-07-01 00:00:00

  • Decoding the representation of numerical values from brain activation patterns.

    abstract::Human neuroimaging studies have increasingly converged on the possibility that the neural representation of specific numbers may be decodable from brain activity, particularly in parietal cortex. Multivariate machine learning techniques have recently demonstrated that the neural representation of individual concrete n...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Damarla SR,Just MA

    更新日期:2013-10-01 00:00:00

  • Event-related potential and functional MRI measures of face-selectivity are highly correlated: a simultaneous ERP-fMRI investigation.

    abstract::A face-selective neural signal is reliably found in humans with functional MRI and event-related potential (ERP) measures, which provide complementary information about the spatial and temporal properties of the neural response. However, because most neuroimaging studies so far have studied ERP and fMRI face-selective...

    journal_title:Human brain mapping

    pub_type: 杂志文章,随机对照试验


    authors: Sadeh B,Podlipsky I,Zhdanov A,Yovel G

    更新日期:2010-10-01 00:00:00

  • Transcranial magnetic stimulation during PET: reaching and verifying the target site.

    abstract::Transcranial magnetic stimulation (TMS) during positron emission tomography (PET) is a novel technique for in vivo measurements of connectivity and excitability of the human cerebral cortex. Here we describe tools that allow investigators to position the stimulating coil over a target region and to verify the actual p...

    journal_title:Human brain mapping

    pub_type: 杂志文章,评审


    authors: Paus T,Wolforth M

    更新日期:1998-01-01 00:00:00

  • Inhibitory saccadic dysfunction is associated with cerebellar injury in multiple sclerosis.

    abstract::Cognitive dysfunction is common in patients with multiple sclerosis (MS). Saccadic eye movement paradigms such as antisaccades (AS) can sensitively interrogate cognitive function, in particular, the executive and attentional processes of response selection and inhibition. Although we have previously demonstrated signi...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Kolbe SC,Kilpatrick TJ,Mitchell PJ,White O,Egan GF,Fielding J

    更新日期:2014-05-01 00:00:00

  • Modeling of the human skull in EEG source analysis.

    abstract::We used computer simulations to investigate finite element models of the layered structure of the human skull in EEG source analysis. Local models, where each skull location was modeled differently, and global models, where the skull was assumed to be homogeneous, were compared to a reference model, in which spongy an...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Dannhauer M,Lanfer B,Wolters CH,Knösche TR

    更新日期:2011-09-01 00:00:00

  • Nonlinear analysis of EEG during NREM sleep reveals changes in functional connectivity due to natural aging.

    abstract::The spatial organization of nonlinear interactions between different brain regions during the first NREM sleep stage is investigated. This is achieved via consideration of four bipolar electrode derivations, Fp1F3, Fp2F4, O1P3, O2P4, which are used to compare anterior and posterior interhemispheric interactions and le...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Terry JR,Anderson C,Horne JA

    更新日期:2004-10-01 00:00:00

  • Disrupted neural variability during propofol-induced sedation and unconsciousness.

    abstract::Variability quenching is a widespread neural phenomenon in which trial-to-trial variability (TTV) of neural activity is reduced by repeated presentations of a sensory stimulus. However, its neural mechanism and functional significance remain poorly understood. Recurrent network dynamics are suggested as a candidate me...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Huang Z,Zhang J,Wu J,Liu X,Xu J,Zhang J,Qin P,Dai R,Yang Z,Mao Y,Hudetz AG,Northoff G

    更新日期:2018-11-01 00:00:00

  • Wavelet-based regularity analysis reveals recurrent spatiotemporal behavior in resting-state fMRI.

    abstract::One of the major findings from multimodal neuroimaging studies in the past decade is that the human brain is anatomically and functionally organized into large-scale networks. In resting state fMRI (rs-fMRI), spatial patterns emerge when temporal correlations between various brain regions are tallied, evidencing netwo...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Smith RX,Jann K,Ances B,Wang DJ

    更新日期:2015-09-01 00:00:00

  • Statistical parametric mapping of LORETA using high density EEG and individual MRI: application to mismatch negativities in schizophrenia.

    abstract::We describe a method for the statistical parametric mapping of low resolution electromagnetic tomography (LORETA) using high-density electroencephalography (EEG) and individual magnetic resonance images (MRI) to investigate the characteristics of the mismatch negativity (MMN) generators in schizophrenia. LORETA, using...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Park HJ,Kwon JS,Youn T,Pae JS,Kim JJ,Kim MS,Ha KS

    更新日期:2002-11-01 00:00:00

  • Evidence for a general performance-monitoring system in the human brain.

    abstract::Adaptive behavior relies on the ability of the brain to form predictions and monitor action outcomes. In the human brain, the same system is thought to monitor action outcomes regardless of whether the information originates from internal (e.g., proprioceptive) and external (e.g., visual) sensory channels. Neural sign...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Zubarev I,Parkkonen L

    更新日期:2018-11-01 00:00:00

  • A brain-wide association study of DISC1 genetic variants reveals a relationship with the structure and functional connectivity of the precuneus in schizophrenia.

    abstract::The Disrupted in Schizophrenia Gene 1 (DISC1) plays a role in both neural signaling and development and is associated with schizophrenia, although its links to altered brain structure and function in this disorder are not fully established. Here we have used structural and functional MRI to investigate links with six ...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Gong X,Lu W,Kendrick KM,Pu W,Wang C,Jin L,Lu G,Liu Z,Liu H,Feng J

    更新日期:2014-11-01 00:00:00

  • Detectability of cerebellar activity with magnetoencephalography and electroencephalography.

    abstract::Electrophysiological signals from the cerebellum have traditionally been viewed as inaccessible to magnetoencephalography (MEG) and electroencephalography (EEG). Here, we challenge this position by investigating the ability of MEG and EEG to detect cerebellar activity using a model that employs a high-resolution tesse...

    journal_title:Human brain mapping

    pub_type: 杂志文章


    authors: Samuelsson JG,Sundaram P,Khan S,Sereno MI,Hämäläinen MS

    更新日期:2020-06-15 00:00:00