Abstract:
:Despite the clinical significance of event-related potential (ERP) latency abnormalities, little attention has focused on the anatomic substrate of latency variability. Volume conduction models do not identify the anatomy responsible for delayed neural transmission between neural sources. To explore the anatomic substrate of ERP latency variability in normal adults using automated measures derived from magnetic resonance imaging (MRI), ERPs were recorded in the visual three-stimulus oddball task in 59 healthy participants. Latencies of the P3a and P3b components were measured at the vertex. Measures of local anatomic size in the brain were estimated from structural MRI, using tissue segmentation and deformation morphometry. A general linear model was fitted relating latency to measures of local anatomic size, covarying for intracranial vault volume. Longer P3b latencies were related to contractions in thalamus extending superiorly into the corpus callosum, white matter (WM) anterior to the central sulcus on the left and right, left temporal WM, the right anterior limb of the internal capsule extending into the lenticular nucleus, and larger cerebrospinal fluid volumes. There was no evidence for a relationship between gray matter (GM) volumes and P3b latency. Longer P3a latencies were related to contractions in left temporal WM, and left parietal GM and WM near the interhemispheric fissure. P3b latency variability is related chiefly to WM, thalamus, and lenticular nucleus, whereas P3a latency variability is not related as strongly to anatomy. These results imply that the WM connectivity between generators influences P3b latency more than the generators themselves do.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Cardenas VA,Chao LL,Blumenfeld R,Song E,Meyerhoff DJ,Weiner MW,Studholme Cdoi
10.1002/hbm.20103keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
317-27issue
3eissn
1065-9471issn
1097-0193journal_volume
25pub_type
杂志文章abstract::Functional connectivity analysis of brain networks has become an important tool for investigation of human brain function. Although functional connectivity computations are usually based on resting-state data, the application to task-specific fMRI has received growing attention. Three major methods for extraction of r...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22897
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Abnormalities in inhibitory control and underlying fronto-striatal networks is common to both attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive-disorder (OCD). The aim of this study was to investigate disorder-specific abnormalities in neural networks mediating interference inhibition ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21048
更新日期:2011-04-01 00:00:00
abstract::Humans can easily recognize others' facial expressions. Among the brain substrates that enable this ability, considerable attention has been paid to face-selective areas; in contrast, whether motion-sensitive areas, which clearly exhibit sensitivity to facial movements, are involved in facial expression recognition re...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23578
更新日期:2017-06-01 00:00:00
abstract::Previous whole-brain functional connectivity studies achieved successful classifications of patients and healthy controls but only offered limited specificity as to affected brain systems. Here, we examined whether the connectivity patterns of functional systems affected in schizophrenia (SCZ), Parkinson's disease (PD...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23763
更新日期:2017-12-01 00:00:00
abstract::Dopaminergic degeneration is a hallmark of Parkinson's disease (PD), which causes various symptoms affected by corticostriatal circuits. So far, the relationship between cortical changes and dopamine loss in the striatum is unclear. Here, we evaluate the gray matter (GM) changes in accordance with striatal dopaminergi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23130
更新日期:2016-05-01 00:00:00
abstract::The overall goal of this work is to demonstrate how resting state functional magnetic resonance imaging (fMRI) signals may be used to objectively parcellate functionally heterogeneous subregions of the human amygdala into structures characterized by similar patterns of functional connectivity. We hypothesize that simi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22249
更新日期:2014-04-01 00:00:00
abstract::Fine surface texture is best discriminated by touch, in contrast to macro geometric features like shape. We used functional magnetic resonance imaging and a delayed match-to-sample task to investigate the neural substrate for working memory of tactile surface texture. Blindfolded right-handed males encoded the texture...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21500
更新日期:2013-05-01 00:00:00
abstract::How the human brain represents distinct motor features into a unique finalized action still remains undefined. Previous models proposed the distinct features of a motor act to be hierarchically organized in separated, but functionally interconnected, cortical areas. Here, we hypothesized that distinct patterns across ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22881
更新日期:2015-10-01 00:00:00
abstract::An increasing amount of studies apply repetetive transcranial magnetic stimulation (rTMS) to treat chronic tinnitus, yet the neurophysiological impacts have remained largely obscure. Several studies show that endogenous brain rhythms may be enhanced via diverse brain stimulation techniques applying rhythmic stimulatio...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22152
更新日期:2014-01-01 00:00:00
abstract::It is widely accepted that abnormalities in the frontal area of the brain underpin the pathophysiology of obsessive-compulsive disorder (OCD). Fundamental to this investigation is the delineation of frontal white matter tracts including dorsal and ventral frontal projections of interhemispheric connections. While prev...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21372
更新日期:2012-10-01 00:00:00
abstract::We used emotional expectancy to study attentional modulation in the processing of emotional stimuli. During functional magnetic resonance imaging (fMRI), volunteers saw emotional and neutral expectancy cues signaling the subsequent presentation of corresponding emotional or neutral pictorial stimuli. As a control, emo...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20209
更新日期:2006-08-01 00:00:00
abstract::BOLD functional MRI (fMRI) data are dominated by low frequency signals, many of them of unclear origin. We have recently shown that some portions of the low frequency oscillations found in BOLD fMRI are systemic signals closely related to the blood circulation (Tong et al. [2013]: NeuroImage 76:202-215). They are comm...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22564
更新日期:2014-11-01 00:00:00
abstract::A thorough understanding of sex differences that exist in the brains of healthy individuals is crucial for the study of neurological illnesses that exhibit phenotypic differences between males and females. Here we evaluate sex differences in regional temporal dependence of resting-state brain activity in 195 adult mal...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25030
更新日期:2020-09-01 00:00:00
abstract::Depressive symptoms often coexist with memory deficits in older adults and also are associated with incident cognitive decline in the elderly. However, little is known about the neural correlates of the association between depressive symptoms and memory deficits in nondemented elderly. Fifteen amnestic mild cognitive ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21291
更新日期:2012-06-01 00:00:00
abstract::In early blindness, the primary visual area (PVA) loses the ability to process visual information, and shifts to working on the processing of somatosensory input, auditory input, and some higher-level cognitive functions. It has not yet been investigated whether such functional changes can lead to alterations of the f...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20420
更新日期:2008-05-01 00:00:00
abstract::Inattentional deafness is the failure to hear otherwise audible sounds (usually alarms) that may occur under high workload conditions. One potential cause for its occurrence could be an attentional bottleneck that occurs when task demands are high, resulting in lack of resources for processing of additional tasks. In ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23735
更新日期:2017-11-01 00:00:00
abstract::Previous studies have demonstrated that the right ventrolateral prefrontal cortex (RVLPFC) is crucially involved in downregulating physical and social pain. However, it remains unclear whether the RVLPFC is more specific to either physical or social pain. The present study compares the role of RVLPFC in emotion regula...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24881
更新日期:2020-04-01 00:00:00
abstract::A diffusion-weighted (DW) template in a standard coordinate system is often necessary for the analysis of white matter (WM) structures using DW images. Although several DW templates have been constructed in the ICBM-152 space, a template for diffusion spectrum imaging (DSI) is still lacking. In this study, we develope...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22860
更新日期:2015-09-01 00:00:00
abstract::Machine learning has increasingly been applied to classification of schizophrenia in neuroimaging research. However, direct replication studies and studies seeking to investigate generalizability are scarce. To address these issues, we assessed within-site and between-site generalizability of a machine learning classi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24797
更新日期:2020-01-01 00:00:00
abstract::Variability in human behavior related to sex is supported by neuroimaging studies showing differences in brain activation patterns during cognitive task performance. An emerging field is examining the human connectome, including networks of brain regions that are not only temporally-correlated during different task co...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20968
更新日期:2010-11-01 00:00:00
abstract::The anticipation of pain has been investigated in a variety of brain imaging studies. Importantly, today there is no clear overall picture of the areas that are involved in different studies and the exact role of these regions in pain expectation remains especially unexploited. To address this issue, we used activatio...
journal_title:Human brain mapping
pub_type: 杂志文章,meta分析
doi:10.1002/hbm.22727
更新日期:2015-05-01 00:00:00
abstract::Human neuroimaging studies have increasingly converged on the possibility that the neural representation of specific numbers may be decodable from brain activity, particularly in parietal cortex. Multivariate machine learning techniques have recently demonstrated that the neural representation of individual concrete n...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22087
更新日期:2013-10-01 00:00:00
abstract::The mirror neuron system (MNS) is considered crucial for human imitation and language learning and provides the basis for the development of empathy and mentalizing. Alexithymia (ALEX), which refers to deficiencies in the self-awareness of emotional states, has been reported to be associated with poor ability in vario...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20653
更新日期:2009-07-01 00:00:00
abstract::Functional organization units of the cerebral cortex exist over a wide range of spatial scales, from local circuits to entire cortical areas. In the last decades, scale-space representations of neuroimaging data suited to probe the multi-scale nature of cortical functional organization have been introduced and methodo...
journal_title:Human brain mapping
pub_type: 杂志文章,随机对照试验
doi:10.1002/hbm.21274
更新日期:2012-05-01 00:00:00
abstract::Infants born prematurely are at increased risk of adverse neurodevelopmental outcome. The measurement of white matter tissue composition and structure can help predict functional performance. Specifically, measurements of myelination and indicators of myelination status in the preterm brain could be predictive of late...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23188
更新日期:2016-07-01 00:00:00
abstract::Experienced video game players exhibit superior performance in visuospatial cognition when compared to non-players. However, very little is known about the relation between video game experience and structural brain plasticity. To address this issue, a direct comparison of the white matter brain structure in RTS (real...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24208
更新日期:2018-09-01 00:00:00
abstract::Diffusion-weighted magnetic resonance imaging allows researchers and clinicians to identify individual white matter fiber tracts and map their trajectories. The reliability and interpretability of fiber-tracking procedures is improved when a priori anatomical information is used as a guide. We have developed an automa...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20619
更新日期:2009-05-01 00:00:00
abstract::Incongruent auditory and visual stimuli can elicit audiovisual illusions such as the McGurk effect where visual /ka/ and auditory /pa/ fuse into another percept such as/ta/. In the present study, human brain activity was measured with adaptation functional magnetic resonance imaging to investigate which brain areas su...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20884
更新日期:2010-04-01 00:00:00
abstract::The acquisition of functional magnetic resonance imaging (fMRI) data in a finite subset of k-space produces ring-artifacts and 'side lobes' that distort the image. In this article, we explore the consequences of this problem for functional imaging studies, which can be considerable, and propose a solution. The truncat...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20475
更新日期:2008-11-01 00:00:00
abstract::Many studies have suggested that childhood maltreatment increase risk of adulthood major depressive disorder (MDD) and predict its unfavorable treatment outcome, yet the neural underpinnings associated with childhood maltreatment in MDD remain poorly understood. Here, we seek to investigate the whole-brain functional ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22241
更新日期:2014-04-01 00:00:00