Abstract:
:The overall goal of this work is to demonstrate how resting state functional magnetic resonance imaging (fMRI) signals may be used to objectively parcellate functionally heterogeneous subregions of the human amygdala into structures characterized by similar patterns of functional connectivity. We hypothesize that similarity of functional connectivity of subregions with other parts of the brain can be a potential basis to segment and cluster voxels using data driven approaches. In this work, self-organizing map (SOM) was implemented to cluster the connectivity maps associated with each voxel of the human amygdala, thereby defining distinct subregions. The functional separation was optimized by evaluating the overall differences in functional connectivity between the subregions at group level. Analysis of 25 resting state fMRI data sets suggests that SOM can successfully identify functionally independent nuclei based on differences in their inter subregional functional connectivity, evaluated statistically at various confidence levels. Although amygdala contains several nuclei whose distinct roles are implicated in various functions, our objective approach discerns at least two functionally distinct volumes comparable to previous parcellation results obtained using probabilistic tractography and cytoarchitectonic analysis. Association of these nuclei with various known functions and a quantitative evaluation of their differences in overall functional connectivity with lateral orbital frontal cortex and temporal pole confirms the functional diversity of amygdala. The data driven approach adopted here may be used as a powerful indicator of structure-function relationships in the amygdala and other functionally heterogeneous structures as well.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Mishra A,Rogers BP,Chen LM,Gore JCdoi
10.1002/hbm.22249subject
Has Abstractpub_date
2014-04-01 00:00:00pages
1247-60issue
4eissn
1065-9471issn
1097-0193journal_volume
35pub_type
杂志文章abstract::We present a new technique for segmentation of skull and scalp in T(1)-weighted magnetic resonance images (MRIs) of the human head. Our method uses mathematical morphological operations to generate realistic models of the skull, scalp, and brain that are suitable for electroencephalography (EEG) and magnetoencephalogr...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20159
更新日期:2005-12-01 00:00:00
abstract::The amygdala, a small deep brain structure involved in behavioral processing through interactions with other brain regions, has garnered increased attention in recent years in relation to pain processing. As pain is a multidimensional experience that encompasses physical sensation, affect, and cognition, the amygdala ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22199
更新日期:2014-02-01 00:00:00
abstract::There have been many functional imaging studies of the brain basis of theory of mind (ToM) skills, but the findings are heterogeneous and implicate anatomical regions as far apart as orbitofrontal cortex and the inferior parietal lobe. The functional imaging studies are reviewed to determine whether the diverse findin...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.20671
更新日期:2009-08-01 00:00:00
abstract::This study evaluated the neural basis of verbal working memory (WM) function in a group of 20 children and adolescents with fetal alcohol spectrum disorders (FASDs) and 20 typically developing comparison participants using functional magnetic resonance imaging (fMRI). Both groups showed prominent activation in the fro...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20741
更新日期:2009-10-01 00:00:00
abstract::Studies of cognitive function that compare the blood oxygenation level dependent (BOLD) signal across age groups often require the assumption that neurovascular coupling does not change with age. Tests of this assumption have produced mixed results regarding the strength of the coupling and its relative time course. U...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23608
更新日期:2017-07-01 00:00:00
abstract::Central brain network connections greatly contribute to overall network efficiency. Here we examined whether small vessel disease (SVD) related white matter alterations in central brain network connections have a greater impact on executive functioning than alterations in non-central brain network connections. Brain n...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23186
更新日期:2016-07-01 00:00:00
abstract::Everyday communication is accompanied by visual information from several sources, including co-speech gestures, which provide semantic information listeners use to help disambiguate the speaker's message. Using fMRI, we examined how gestures influence neural activity in brain regions associated with processing semanti...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20774
更新日期:2009-11-01 00:00:00
abstract::We previously showed that dual-task cost (DTC) on gait speed in people with Parkinson's disease (PD) improved after 6 weeks of the Agility Boot Camp with Cognitive Challenge (ABC-C) exercise program. Since deficits in dual-task gait speed are associated with freezing of gait and gray matter atrophy, here we performed ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25211
更新日期:2021-01-01 00:00:00
abstract::Patients with schizophrenia have patterns of brain deficits including reduced cortical thickness, subcortical gray matter volumes, and cerebral white matter integrity. We proposed the regional vulnerability index (RVI) to translate the results of Enhancing Neuro Imaging Genetics Meta-Analysis studies to the individual...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25045
更新日期:2020-05-28 00:00:00
abstract::Reproducibility is one of the most important issues for generalizing the results of clinical research; however, low reproducibility in neuroimaging studies is well known. To overcome this problem, the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium, an international neuroimaging consortium, e...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.25040
更新日期:2020-06-05 00:00:00
abstract::Numerous studies suggest that interhemispheric inhibition-relayed via the corpus callosum-plays an important role in unilateral hand motions. Interestingly, transcallosal inhibition appears to be indicative of a strong laterality effect, where generally the dominant hemisphere exerts inhibition on the nondominant one....
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22060
更新日期:2013-09-01 00:00:00
abstract::We present a method for registering a brain in the Talairach coordinate system that can be performed either "online," i.e., in real time while a subject is in a magnetic resonance scanner, or "offline" on a previously acquired three-dimensional (3D) data set. The method is applicable to functional magnetic resonance i...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1997)5:1<58::AID-HBM6>3.0.
更新日期:1997-01-01 00:00:00
abstract::This meta-analysis explores the location and function of brain areas involved in social cognition, or the capacity to understand people's behavioral intentions, social beliefs, and personality traits. On the basis of over 200 fMRI studies, it tests alternative theoretical proposals that attempt to explain how several ...
journal_title:Human brain mapping
pub_type: 杂志文章,meta分析
doi:10.1002/hbm.20547
更新日期:2009-03-01 00:00:00
abstract::Our objective was to develop a diffusion tensor MR imaging pulse sequence that allows whole brain coverage with isotropic resolution within a clinically acceptable time. A single-shot, cardiac-gated MR pulse sequence, optimized for measuring the diffusion tensor in human brain, was developed to provide whole-brain cov...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.10018
更新日期:2002-04-01 00:00:00
abstract::Bimanual movements involve the interactions between both primary motor cortices. These interactions are assumed to involve phase-locked oscillatory brain activity referred to as inter-hemispheric functional coupling. So far, inter-hemispheric functional coupling has been investigated as a function of motor performance...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23663
更新日期:2017-09-01 00:00:00
abstract::Incongruent auditory and visual stimuli can elicit audiovisual illusions such as the McGurk effect where visual /ka/ and auditory /pa/ fuse into another percept such as/ta/. In the present study, human brain activity was measured with adaptation functional magnetic resonance imaging to investigate which brain areas su...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20884
更新日期:2010-04-01 00:00:00
abstract::The spatial organization of nonlinear interactions between different brain regions during the first NREM sleep stage is investigated. This is achieved via consideration of four bipolar electrode derivations, Fp1F3, Fp2F4, O1P3, O2P4, which are used to compare anterior and posterior interhemispheric interactions and le...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20052
更新日期:2004-10-01 00:00:00
abstract::Many studies have suggested that childhood maltreatment increase risk of adulthood major depressive disorder (MDD) and predict its unfavorable treatment outcome, yet the neural underpinnings associated with childhood maltreatment in MDD remain poorly understood. Here, we seek to investigate the whole-brain functional ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22241
更新日期:2014-04-01 00:00:00
abstract::In addition to its role in visuospatial navigation and the generation of spatial representations, in recent years, the hippocampus has been proposed to support perceptual processes. This is especially the case where high-resolution details, in the form of fine-grained relationships between features such as angles betw...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24865
更新日期:2020-04-01 00:00:00
abstract::The origin, structure, and function of the claustrum, as well as its role in neural computation, have remained a mystery since its discovery in the 17th century. Assessing the in vivo connectivity of the claustrum may bring forth useful insights with relevance to model the overall functionality of the claustrum itself...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22667
更新日期:2015-03-01 00:00:00
abstract::Developmental neuropsychology and functional neuroimaging evidence indicates that simple and complex mental calculation is subserved by a fronto-parietal network. However, the effective connectivity (connection direction and strength) among regions within the fronto-parietal network is still unexplored. Combining even...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21119
更新日期:2011-09-01 00:00:00
abstract::Verbal stimuli often induce right-hemispheric activation in patients with aphasia after left-hemispheric stroke. This right-hemispheric activation is commonly attributed to functional reorganization within the language system. Yet previous evidence suggests that functional activation in right-hemispheric homologues of...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21512
更新日期:2013-06-01 00:00:00
abstract::The hypothalamus is of enormous importance for multiple bodily functions such as energy homeostasis. Especially, rodent studies have greatly contributed to our understanding how specific hypothalamic subregions integrate peripheral and central signals into the brain to control food intake. In humans, however, the neur...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22607
更新日期:2014-12-01 00:00:00
abstract::Major depressive disorder (MDD) is highly prevalent and associated with considerable morbidity, yet its pathophysiology remains only partially understood. While numerous studies have investigated the neurobiological correlates of MDD, most have used only a single neuroimaging modality. In particular, diffusion tensor ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24679
更新日期:2019-09-01 00:00:00
abstract::Both increases and decreases in resting state functional connectivity have been previously observed within the motor network during aging. Moreover, the relationship between altered functional connectivity and age-related declines in bimanual coordination remains unclear. Here, we explored the developmental dynamics o...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22450
更新日期:2014-08-01 00:00:00
abstract::We aimed to investigate the structural neuroplasticity associated with different levels of sports experience and its effect on the corresponding resting-state functional circuitry. We recruited 18 skilled baseball batters (SB), 19 intermediate baseball batters (IB), and 17 healthy controls (HC), and used magnetic reso...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24280
更新日期:2018-11-01 00:00:00
abstract::The resting state default mode network (DMN) has been shown to characterize a number of neurological and psychiatric disorders. Evidence suggests an underlying genetic basis for this network and hence could serve as potential endophenotype for these disorders. Heritability is a defining criterion for endophenotypes. T...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22446
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:The serotonin transporter (5-HTT) and the 5-HTTLPR/rs25531 polymorphisms in its gene (SLC6A4) have been associated with depression, increased stress-response, and brain structural alterations such as reduced hippocampal volumes. Recently, epigenetic processes including SLC6A4 promoter methylation were shown ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22555
更新日期:2014-11-01 00:00:00
abstract::Constrained spherical deconvolution (CSD) is a new technique that, based on high-angular resolution diffusion imaging (HARDI) MR data, estimates the orientation of multiple intravoxel fiber populations within regions of complex white matter architecture, thereby overcoming the limitations of the widely used diffusion ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21032
更新日期:2011-03-01 00:00:00
abstract::Social norms have a critical role in everyday decision-making, as frequent interaction with others regulates our behavior. Neuroimaging studies show that social-based and fairness-related decision-making activates an inconsistent set of areas, which sometimes includes the anterior insula, anterior cingulate cortex, an...
journal_title:Human brain mapping
pub_type: 杂志文章,meta分析
doi:10.1002/hbm.23895
更新日期:2018-02-01 00:00:00