Abstract:
:Studies of cognitive function that compare the blood oxygenation level dependent (BOLD) signal across age groups often require the assumption that neurovascular coupling does not change with age. Tests of this assumption have produced mixed results regarding the strength of the coupling and its relative time course. Using deconvolution, we found that age does not have a significant effect on the time course of the hemodynamic impulse response function or on the slope of the BOLD versus stimulus duration relationship. These results suggest that in cognitive studies of healthy aging, group differences in BOLD activation are likely due to age-related changes in cognitive-neural interactions and information processing rather than to impairments in neurovascular coupling. Hum Brain Mapp 38:3538-3551, 2017. © 2017 Wiley Periodicals, Inc.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Grinband J,Steffener J,Razlighi QR,Stern Ydoi
10.1002/hbm.23608subject
Has Abstractpub_date
2017-07-01 00:00:00pages
3538-3551issue
7eissn
1065-9471issn
1097-0193journal_volume
38pub_type
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