BOLD neurovascular coupling does not change significantly with normal aging.

Abstract:

:Studies of cognitive function that compare the blood oxygenation level dependent (BOLD) signal across age groups often require the assumption that neurovascular coupling does not change with age. Tests of this assumption have produced mixed results regarding the strength of the coupling and its relative time course. Using deconvolution, we found that age does not have a significant effect on the time course of the hemodynamic impulse response function or on the slope of the BOLD versus stimulus duration relationship. These results suggest that in cognitive studies of healthy aging, group differences in BOLD activation are likely due to age-related changes in cognitive-neural interactions and information processing rather than to impairments in neurovascular coupling. Hum Brain Mapp 38:3538-3551, 2017. © 2017 Wiley Periodicals, Inc.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Grinband J,Steffener J,Razlighi QR,Stern Y

doi

10.1002/hbm.23608

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

3538-3551

issue

7

eissn

1065-9471

issn

1097-0193

journal_volume

38

pub_type

杂志文章
  • Generalizability of machine learning for classification of schizophrenia based on resting-state functional MRI data.

    abstract::Machine learning has increasingly been applied to classification of schizophrenia in neuroimaging research. However, direct replication studies and studies seeking to investigate generalizability are scarce. To address these issues, we assessed within-site and between-site generalizability of a machine learning classi...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24797

    authors: Cai XL,Xie DJ,Madsen KH,Wang YM,Bögemann SA,Cheung EFC,Møller A,Chan RCK

    更新日期:2020-01-01 00:00:00

  • Preferential encoding of movement amplitude and speed in the primary motor cortex and cerebellum.

    abstract::Voluntary movements require control of multiple kinematic parameters, a task carried out by a distributed brain architecture. However, it remains unclear whether regions along the motor system encode single, or rather a mixture of, kinematic parameters during action execution. Here, rapid event-related functional magn...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23802

    authors: Stark-Inbar A,Dayan E

    更新日期:2017-12-01 00:00:00

  • B-SPID: an object-relational database architecture to store, retrieve, and manipulate neuroimaging data.

    abstract::We propose a hardware and software architecture to respond to crucial problems in the neuroimaging field: storage, retrieval, and processing of large datasets. The B-SPID project, here discussed, concerns the processing of neuroimages and attached components stored in an object-relational multimedia database managemen...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0193(1999)7:2<136::aid-hbm6>3.0

    authors: Diallo B,Dolidon F,Travere JM,Mazoyer B

    更新日期:1999-01-01 00:00:00

  • Drawing on mind's canvas: differences in cortical integration patterns between artists and non-artists.

    abstract::Our primary question was to learn whether mentally composing drawings of their own choice produce different brain electric features in artists and laymen. To this purpose, we studied multichannel electroencephalograph (EEG) signals from two broad groups (all participants were females): artists (professionally trained ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20104

    authors: Bhattacharya J,Petsche H

    更新日期:2005-09-01 00:00:00

  • Impaired structural connectivity between dorsal attention network and pulvinar mediates the impact of premature birth on adult visual-spatial abilities.

    abstract::The dorsal attention network (DAN), including frontal eye fields and posterior parietal cortices, and its link with the posterior thalamus, contribute to visual-spatial abilities. Very premature birth impairs both visual-spatial abilities and cortico-thalamic structural connectivity. We hypothesized that impaired stru...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24685

    authors: Berndt M,Bäuml JG,Menegaux A,Meng C,Daamen M,Baumann N,Zimmer C,Boecker H,Bartmann P,Wolke D,Sorg C

    更新日期:2019-10-01 00:00:00

  • Volumetric and shape analysis of the thalamus in first-episode schizophrenia.

    abstract::Thalamic abnormalities have been implicated in the pathogenesis of schizophrenia, although the majority of studies used chronic samples treated extensively with antipsychotics. Moreover, the clinical and neuropsychological correlates of these abnormalities remain largely unknown. Using high-resolution MR imaging and n...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20595

    authors: Coscia DM,Narr KL,Robinson DG,Hamilton LS,Sevy S,Burdick KE,Gunduz-Bruce H,McCormack J,Bilder RM,Szeszko PR

    更新日期:2009-04-01 00:00:00

  • Dissociation of mnemonic and perceptual processes during spatial and nonspatial working memory using fMRI.

    abstract::Neuroimaging studies in humans have consistently found robust activation of frontal, parietal, and temporal regions during working memory tasks. Whether these activations represent functional networks segregated by perceptual domain is still at issue. Two functional magnetic resonance imaging experiments were conducte...

    journal_title:Human brain mapping

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Belger A,Puce A,Krystal JH,Gore JC,Goldman-Rakic P,McCarthy G

    更新日期:1998-01-01 00:00:00

  • Spatiotemporal, metabolic, and therapeutic characterization of altered functional connectivity in major depressive disorder.

    abstract::Although imbalanced functional integration has been increasingly reported in major depressive disorder (MDD), there still lacks a general framework to characterize common characteristic and origin shared by the integrative disturbances. Here we examined spatial selectivity, temporal uniqueness, metabolic basis, and th...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23976

    authors: Sheng J,Shen Y,Qin Y,Zhang L,Jiang B,Li Y,Xu L,Chen W,Wang J

    更新日期:2018-05-01 00:00:00

  • A method for multitask fMRI data fusion applied to schizophrenia.

    abstract::It is becoming common to collect data from multiple functional magnetic resonance imaging (fMRI) paradigms on a single individual. The data from these experiments are typically analyzed separately and sometimes directly subtracted from one another on a voxel-by-voxel basis. These comparative approaches, although usefu...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20204

    authors: Calhoun VD,Adali T,Kiehl KA,Astur R,Pekar JJ,Pearlson GD

    更新日期:2006-07-01 00:00:00

  • The influence of positive and negative emotional associations on semantic processing in depression: an fMRI study.

    abstract::In depression, patients suffer from emotional and cognitive deficits, among others in semantic processing. If these semantic deficits are cognitive or interact with emotional dysfunctions, is still an open question. The aim of the current study was to investigate the influence of emotional valence on the neural correl...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22186

    authors: Sass K,Habel U,Kellermann T,Mathiak K,Gauggel S,Kircher T

    更新日期:2014-02-01 00:00:00

  • Gray matter correlates of dopaminergic degeneration in Parkinson's disease: A hybrid PET/MR study using (18) F-FP-CIT.

    abstract::Dopaminergic degeneration is a hallmark of Parkinson's disease (PD), which causes various symptoms affected by corticostriatal circuits. So far, the relationship between cortical changes and dopamine loss in the striatum is unclear. Here, we evaluate the gray matter (GM) changes in accordance with striatal dopaminergi...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23130

    authors: Choi H,Cheon GJ,Kim HJ,Choi SH,Kim YI,Kang KW,Chung JK,Kim EE,Lee DS

    更新日期:2016-05-01 00:00:00

  • Comparison of continuously acquired resting state and extracted analogues from active tasks.

    abstract::Functional connectivity analysis of brain networks has become an important tool for investigation of human brain function. Although functional connectivity computations are usually based on resting-state data, the application to task-specific fMRI has received growing attention. Three major methods for extraction of r...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22897

    authors: Ganger S,Hahn A,Küblböck M,Kranz GS,Spies M,Vanicek T,Seiger R,Sladky R,Windischberger C,Kasper S,Lanzenberger R

    更新日期:2015-10-01 00:00:00

  • Multimodal fusion of structural and functional brain imaging in depression using linked independent component analysis.

    abstract::Previous structural and functional neuroimaging studies have implicated distributed brain regions and networks in depression. However, there are no robust imaging biomarkers that are specific to depression, which may be due to clinical heterogeneity and neurobiological complexity. A dimensional approach and fusion of ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24802

    authors: Maglanoc LA,Kaufmann T,Jonassen R,Hilland E,Beck D,Landrø NI,Westlye LT

    更新日期:2020-01-01 00:00:00

  • Statistical parametric mapping of LORETA using high density EEG and individual MRI: application to mismatch negativities in schizophrenia.

    abstract::We describe a method for the statistical parametric mapping of low resolution electromagnetic tomography (LORETA) using high-density electroencephalography (EEG) and individual magnetic resonance images (MRI) to investigate the characteristics of the mismatch negativity (MMN) generators in schizophrenia. LORETA, using...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.10059

    authors: Park HJ,Kwon JS,Youn T,Pae JS,Kim JJ,Kim MS,Ha KS

    更新日期:2002-11-01 00:00:00

  • Connectivity-based parcellation of the anterior limb of the internal capsule.

    abstract::The anterior limb of the internal capsule (ALIC) is an important locus of frontal-subcortical fiber tracts involved in cognitive and limbic feedback loops. However, the structural organization of its component fiber tracts remains unclear. Therefore, although the ALIC is a promising target for various neurosurgical pr...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23815

    authors: Nanda P,Banks GP,Pathak YJ,Sheth SA

    更新日期:2017-12-01 00:00:00

  • High-resolution intersubject averaging and a coordinate system for the cortical surface.

    abstract::The neurons of the human cerebral cortex are arranged in a highly folded sheet, with the majority of the cortical surface area buried in folds. Cortical maps are typically arranged with a topography oriented parallel to the cortical surface. Despite this unambiguous sheetlike geometry, the most commonly used coordinat...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0193(1999)8:4<272::aid-hbm10>3.

    authors: Fischl B,Sereno MI,Tootell RB,Dale AM

    更新日期:1999-01-01 00:00:00

  • Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills.

    abstract::Developmental dyslexia affects 40-60% of children with a familial risk (FHD+) compared to a general prevalence of 5-10%. Despite the increased risk, about half of FHD+ children develop typical reading abilities (FHD+Typical). Yet the underlying neural characteristics of favorable reading outcomes in at-risk children r...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24980

    authors: Yu X,Zuk J,Perdue MV,Ozernov-Palchik O,Raney T,Beach SD,Norton ES,Ou Y,Gabrieli JDE,Gaab N

    更新日期:2020-07-01 00:00:00

  • Fast robust subject-independent magnetoencephalographic source localization using an artificial neural network.

    abstract::We describe a system that localizes a single dipole to reasonable accuracy from noisy magnetoencephalographic (MEG) measurements in real time. At its core is a multilayer perceptron (MLP) trained to map sensor signals and head position to dipole location. Including head position overcomes the previous need to retrain ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20068

    authors: Jun SC,Pearlmutter BA

    更新日期:2005-01-01 00:00:00

  • The right VLPFC and downregulation of social pain: A TMS study.

    abstract::Previous studies have demonstrated that the right ventrolateral prefrontal cortex (RVLPFC) is crucially involved in downregulating physical and social pain. However, it remains unclear whether the RVLPFC is more specific to either physical or social pain. The present study compares the role of RVLPFC in emotion regula...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24881

    authors: He Z,Zhao J,Shen J,Muhlert N,Elliott R,Zhang D

    更新日期:2020-04-01 00:00:00

  • Speed of saccade execution and inhibition associated with fractional anisotropy in distinct fronto-frontal and fronto-striatal white matter pathways.

    abstract::Fast cancellation or switching of action plans is a critical cognitive function. Rapid signal transmission is key for quickly executing and inhibiting responses, and the structural integrity of connections between brain regions plays a crucial role in signal transmission speed. In this study, we used the search-step t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23209

    authors: Thakkar KN,van den Heiligenberg FM,Kahn RS,Neggers SF

    更新日期:2016-08-01 00:00:00

  • Free water elimination improves test-retest reproducibility of diffusion tensor imaging indices in the brain: A longitudinal multisite study of healthy elderly subjects.

    abstract::Free water elimination (FWE) in brain diffusion MRI has been shown to improve tissue specificity in human white matter characterization both in health and in disease. Relative to the classical diffusion tensor imaging (DTI) model, FWE is also expected to increase sensitivity to microstructural changes in longitudinal ...

    journal_title:Human brain mapping

    pub_type: 杂志文章,多中心研究

    doi:10.1002/hbm.23350

    authors: Albi A,Pasternak O,Minati L,Marizzoni M,Bartrés-Faz D,Bargalló N,Bosch B,Rossini PM,Marra C,Müller B,Fiedler U,Wiltfang J,Roccatagliata L,Picco A,Nobili FM,Blin O,Sein J,Ranjeva JP,Didic M,Bombois S,Lopes R,Bord

    更新日期:2017-01-01 00:00:00

  • Group-level variations in motor representation areas of thenar and anterior tibial muscles: Navigated Transcranial Magnetic Stimulation Study.

    abstract::Navigated transcranial magnetic stimulation (TMS) can be used to stimulate functional cortical areas at precise anatomical location to induce measurable responses. The stimulation has commonly been focused on anatomically predefined motor areas: TMS of that area elicits a measurable muscle response, the motor evoked p...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20942

    authors: Niskanen E,Julkunen P,Säisänen L,Vanninen R,Karjalainen P,Könönen M

    更新日期:2010-08-01 00:00:00

  • 3D tract-specific local and global analysis of white matter integrity in Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by progressive decline in memory and other aspects of cognitive function. Diffusion-weighted imaging (DWI) offers a non-invasive approach to delineate the effects of AD on white matter (WM) integrity. Previous studies calculated either some ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23448

    authors: Jin Y,Huang C,Daianu M,Zhan L,Dennis EL,Reid RI,Jack CR Jr,Zhu H,Thompson PM,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2017-03-01 00:00:00

  • Serotonin transporter gene methylation is associated with hippocampal gray matter volume.

    abstract:BACKGROUND:The serotonin transporter (5-HTT) and the 5-HTTLPR/rs25531 polymorphisms in its gene (SLC6A4) have been associated with depression, increased stress-response, and brain structural alterations such as reduced hippocampal volumes. Recently, epigenetic processes including SLC6A4 promoter methylation were shown ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22555

    authors: Dannlowski U,Kugel H,Redlich R,Halik A,Schneider I,Opel N,Grotegerd D,Schwarte K,Schettler C,Ambrée O,Rust S,Domschke K,Arolt V,Heindel W,Baune BT,Suslow T,Zhang W,Hohoff C

    更新日期:2014-11-01 00:00:00

  • Alterations in intrinsic fronto-thalamo-parietal connectivity are associated with cognitive control deficits in psychotic disorders.

    abstract::Despite a growing number of reports about alterations in intrinsic/resting brain activity observed in patients with psychotic disorders, their relevance to well-established cognitive control deficits in this patient group is not well understood. Totally 88 clinically stabilized patients with a psychotic disorder and 5...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24362

    authors: Lencer R,Yao L,Reilly JL,Keedy SK,McDowell JE,Keshavan MS,Pearlson GD,Tamminga CA,Gershon ES,Clementz BA,Lui S,Sweeney JA

    更新日期:2019-01-01 00:00:00

  • Reduced functional connectivity during controlled semantic integration in schizophrenia: A multivariate approach.

    abstract::Impairment in controlled semantic association is a central feature of schizophrenia, and the goal of the current functional magnetic resonance imaging study was to identify the neural correlates of this impairment. Thirty people with schizophrenia and 30 healthy age- and gender-matched control subjects performed a tas...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22820

    authors: Woodward TS,Tipper CM,Leung AL,Lavigne KM,Sanford N,Metzak PD

    更新日期:2015-08-01 00:00:00

  • Invariance of firing rate and field potential dynamics to stimulus modulation rate in human auditory cortex.

    abstract::The effect of stimulus modulation rate on the underlying neural activity in human auditory cortex is not clear. Human studies (using both invasive and noninvasive techniques) have demonstrated that at the population level, auditory cortex follows stimulus envelope. Here we examined the effect of stimulus modulation ra...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21100

    authors: Mukamel R,Nir Y,Harel M,Arieli A,Malach R,Fried I

    更新日期:2011-08-01 00:00:00

  • Modulative effects of COMT haplotype on age-related associations with brain morphology.

    abstract::Catechol-O-methyltransferase (COMT), located on chromosome 22q11.2, encodes an enzyme critical for dopamine flux in the prefrontal cortex. Genetic variants of COMT have been suggested to functionally manipulate prefrontal morphology and function in healthy adults. This study aims to investigate modulative roles of ind...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23161

    authors: Lee A,Qiu A

    更新日期:2016-06-01 00:00:00

  • Modeling of the human skull in EEG source analysis.

    abstract::We used computer simulations to investigate finite element models of the layered structure of the human skull in EEG source analysis. Local models, where each skull location was modeled differently, and global models, where the skull was assumed to be homogeneous, were compared to a reference model, in which spongy an...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21114

    authors: Dannhauer M,Lanfer B,Wolters CH,Knösche TR

    更新日期:2011-09-01 00:00:00

  • Functional connectivity with cortical depth assessed by resting state fMRI of subregions of S1 in squirrel monkeys.

    abstract::Whereas resting state blood oxygenation-level dependent (BOLD) functional MRI has been widely used to assess functional connectivity between cortical regions, the laminar specificity of such measures is poorly understood. This study aims to determine: (a) whether the resting state functional connectivity (rsFC) betwee...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24375

    authors: Mishra A,Majumdar S,Wang F,Wilson GH 3rd,Gore JC,Chen LM

    更新日期:2019-01-01 00:00:00