Abstract:
BACKGROUND:The serotonin transporter (5-HTT) and the 5-HTTLPR/rs25531 polymorphisms in its gene (SLC6A4) have been associated with depression, increased stress-response, and brain structural alterations such as reduced hippocampal volumes. Recently, epigenetic processes including SLC6A4 promoter methylation were shown to be affected by stress, trauma, or maltreatment and are regarded to be involved in the etiology of affective disorders. However, neurobiological correlates of SLC6A4 promoter methylation have never been studied or compared to genotype effects by means of human neuroimaging hitherto METHODS:Healthy subjects were recruited in two independent samples (N = 94, N = 95) to obtain structural gray matter images processed by voxel-based morphometry (VBM8), focusing on hippocampal, amygdala, and anterior cingulate gyrus gray matter structure. SLC6A4 promoter methylation within an AluJb element and 5-HTTLPR/rs25531 genotypes were analyzed in view of a possible impact on local gray matter volume RESULTS:Strong associations of AluJb methylation and hippocampal gray matter volumes emerged within each sample separately, which in the combined sample withstood most conservative alpha-corrections for the entire brain. The amygdala, insula, and caudate nucleus showed similar associations. The 5-HTTLPR/rs25531 showed no main effect on gray matter, and the effect of methylation rates on hippocampal structure was comparable among the genotype groups CONCLUSIONS:Methylation within the AluJb appears to have strong effects on hippocampal gray matter volumes, indicating that epigenetic processes can alter brain structures crucially involved in stress-related disorders. Different ways of regulating SLC6A4 expression might involve exonization or transcription factor binding as potentially underlying mechanisms, which, however, is speculative and warrants further investigation.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Dannlowski U,Kugel H,Redlich R,Halik A,Schneider I,Opel N,Grotegerd D,Schwarte K,Schettler C,Ambrée O,Rust S,Domschke K,Arolt V,Heindel W,Baune BT,Suslow T,Zhang W,Hohoff Cdoi
10.1002/hbm.22555subject
Has Abstractpub_date
2014-11-01 00:00:00pages
5356-67issue
11eissn
1065-9471issn
1097-0193journal_volume
35pub_type
杂志文章abstract::3,4-Methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a psychostimulant drug producing heightened mood and facilitated social communication. In animal studies, MDMA effects are primarily mediated by serotonin (5-HT), but also by dopamine (DA) and possibly noradrenaline (NA). In humans, however, the neurochemical and ...
journal_title:Human brain mapping
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/hbm.1049
更新日期:2001-11-01 00:00:00
abstract::During complex tasks, patterns of functional connectivity differ from those in the resting state. However, what accounts for such differences remains unclear. Brain activity during a task reflects an unknown mixture of spontaneous and task-evoked activities. The difference in functional connectivity between a task sta...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24335
更新日期:2018-12-01 00:00:00
abstract::Habituation is a basic process of learning in which repeated exposure to a sensory stimulus leads to a decrease in the strength of neuronal activations and behavioral responses. In addition to increases in neuronal activity, sensory stimuli can also lead to decreases in neuronal activity. Until now, the effects of hab...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22163
更新日期:2014-01-01 00:00:00
abstract::Coordinate-based, voxel-wise meta-analysis is an exciting recent addition to the human functional brain mapping literature. In view of the critical importance of selection criteria for any valid meta-analysis, a taxonomy of experimental design should be an important tool for aiding in the design of rigorous meta-analy...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20141
更新日期:2005-05-01 00:00:00
abstract::Prenatal alcohol exposure (PAE) can cause central nervous system dysfunction and widespread structural anomalies as detected by magnetic resonance imaging (MRI). This study focused on diffusion tensor imaging (DTI) of white matter in a large sample of PAE participants that allowed us to examine correlations with behav...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23371
更新日期:2017-01-01 00:00:00
abstract::Language is typically a function of the left hemisphere but the right hemisphere is also essential in some healthy individuals and patients. This inter-subject variability necessitates the localization of language function, at the individual level, prior to neurosurgical intervention. Such assessments are typically ma...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21130
更新日期:2011-10-01 00:00:00
abstract::Working memory (WM) performance is very often measured using the n-back task, in which the participant is presented with a sequence of stimuli, and required to indicate whether the current stimulus matches the one presented n steps earlier. In this study, we used high-density electroencephalography (hdEEG) coupled to ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25283
更新日期:2020-11-17 00:00:00
abstract::Previous whole-brain functional connectivity studies achieved successful classifications of patients and healthy controls but only offered limited specificity as to affected brain systems. Here, we examined whether the connectivity patterns of functional systems affected in schizophrenia (SCZ), Parkinson's disease (PD...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23763
更新日期:2017-12-01 00:00:00
abstract::The mirror neuron system (MNS) is considered crucial for human imitation and language learning and provides the basis for the development of empathy and mentalizing. Alexithymia (ALEX), which refers to deficiencies in the self-awareness of emotional states, has been reported to be associated with poor ability in vario...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20653
更新日期:2009-07-01 00:00:00
abstract::Here, we ask whether frontotemporal cortex is functionally dissociated into distributed lexical and category-specific semantic networks. To this end, fMRI activation patterns elicited during the processing of words from different semantic categories were categorized using k-means cluster algorithms. Results showed a d...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20811
更新日期:2009-12-01 00:00:00
abstract::Task-switching performance relies on a broadly distributed frontoparietal network and declines in older adults. In this study, they investigated whether this age-related decline in task switching performance was mediated by variability in global or regional white matter microstructural health. Seventy cognitively inta...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23473
更新日期:2017-03-01 00:00:00
abstract::Neurodegenerative diseases such as Alzheimer's disease (AD) have been recognized to exhibit disease-specific brain vulnerability patterns. Apolipoprotein E (APOE) ɛ4 allele imparts a high genetic risk of developing AD. Whether the APOE ɛ4 allele damages the brain when cognitive functions are still intact is important ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23359
更新日期:2017-01-01 00:00:00
abstract::The theory of material specific lateralization of memory function posits that left and right MTL regions are asymmetrically involved in mnemonic processing of verbal and nonverbal material respectively. Lesion and functional imaging (fMRI) studies provide robust evidence for a left MTL asymmetry in the verbal memory d...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23077
更新日期:2016-03-01 00:00:00
abstract::Reproducibility is one of the most important issues for generalizing the results of clinical research; however, low reproducibility in neuroimaging studies is well known. To overcome this problem, the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium, an international neuroimaging consortium, e...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.25040
更新日期:2020-06-05 00:00:00
abstract::Magnetic resonance imaging of subcortical gray matter structures, which mediate behavior, cognition and the pathophysiology of several diseases, is crucial for establishing typical maturation patterns across the human lifespan. This single site study examines T1-weighted MPRAGE images of 3 healthy cohorts: (i) a cross...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23604
更新日期:2017-08-01 00:00:00
abstract::It is assumed widely that the clinical expression of Parkinson's Disease (PD), both motor and cognitive, is subtended by topographically distributed brain networks. However, little is known about the functional neuroanatomy of executive dysfunction in PD. Our objective was to validate further in a PD group the use of ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20033
更新日期:2004-07-01 00:00:00
abstract::Joint attention behaviors include initiating one's own and responding to another's bid for joint attention to an object, person, or topic. Joint attention abilities in autism are pervasively atypical, correlate with development of language and social abilities, and discriminate children with autism from other developm...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22086
更新日期:2013-10-01 00:00:00
abstract::Positive number arithmetic is based on combining and separating sets of items, with systematic differences in brain activity in specific regions depending on operation. In contrast, arithmetic with negative numbers involves manipulating abstract values worth less than zero, possibly involving different operation-activ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22201
更新日期:2014-02-01 00:00:00
abstract::The overall goal of this work is to demonstrate how resting state functional magnetic resonance imaging (fMRI) signals may be used to objectively parcellate functionally heterogeneous subregions of the human amygdala into structures characterized by similar patterns of functional connectivity. We hypothesize that simi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22249
更新日期:2014-04-01 00:00:00
abstract::Dynamic functional brain connectivity analysis is a fast expanding field in computational neuroscience research with the promise of elucidating brain network interactions. Sliding temporal window based approaches are commonly used in order to explore dynamic behavior of brain networks in task-free functional magnetic ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23151
更新日期:2016-05-01 00:00:00
abstract::Persistent developmental stuttering is a neurological disorder that commonly manifests as a motor problem. Cognitive theories, however, hold that poorly developed cognitive skills are the origins of stuttering. Working memory (WM), a multicomponent cognitive system that mediates information maintenance and manipulatio...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24366
更新日期:2019-01-01 00:00:00
abstract::The sudden onset of a face image leads to a prominent face-selective response in human scalp electroencephalographic (EEG) recordings, peaking 170 ms after stimulus onset at occipito-temporal (OT) scalp sites: the N170 (or M170 in magnetoencephalography). According to a widely held view, the main cortical source of th...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24455
更新日期:2019-04-01 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disorder with dysfunction in cortices as well as white matter (WM) tracts. While the changes to WM structure have been extensively investigated in PD, the nature of the functional changes to WM remains unknown. In this study, the regional activity and functional connecti...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24444
更新日期:2019-03-01 00:00:00
abstract::Musical expertise is visible both in the morphology and functionality of the brain. Recent research indicates that functional integration between multi-sensory, somato-motor, default-mode (DMN), and salience (SN) networks of the brain differentiates musicians from non-musicians during resting state. Here, we aimed at ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23565
更新日期:2017-06-01 00:00:00
abstract::Understanding the associations between brain biomarkers (BMs) and cognition across age is of paramount importance. Five hundred and sixty-two participants (19-80 years old, 16 mean years of education) were studied. Data from structural T1, diffusion tensor imaging, fluid-attenuated inversion recovery, and resting-stat...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24634
更新日期:2019-09-01 00:00:00
abstract::Cognitive procedural learning occurs in three qualitatively different phases (cognitive, associative, and autonomous). At the beginning of this process, numerous cognitive functions are involved, subtended by distinct brain structures such as the prefrontal and parietal cortex and the cerebellum. As the learning progr...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20605
更新日期:2009-04-01 00:00:00
abstract::The neural basis of the automatic activation of words was investigated in an fMRI study. In the study, words were presented briefly (51 or 151 msec) followed by a mask. To prevent attentional processing, subjects attended to the masks and not the words, and were required to make perceptual judgment about the masks. We...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.10096
更新日期:2003-03-01 00:00:00
abstract::Dysfunction of corticostriatal loops has been proposed to underlie certain cognitive and behavioral problems associated with various neuropsychiatric disorders, such as obsessive-compulsive disorder (OCD) characterized by repetitive, unwanted thoughts, and behaviors. Although functional abnormalities in the loops invo...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23347
更新日期:2017-01-01 00:00:00
abstract::Impairment in controlled semantic association is a central feature of schizophrenia, and the goal of the current functional magnetic resonance imaging study was to identify the neural correlates of this impairment. Thirty people with schizophrenia and 30 healthy age- and gender-matched control subjects performed a tas...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22820
更新日期:2015-08-01 00:00:00
abstract::Verbal stimuli often induce right-hemispheric activation in patients with aphasia after left-hemispheric stroke. This right-hemispheric activation is commonly attributed to functional reorganization within the language system. Yet previous evidence suggests that functional activation in right-hemispheric homologues of...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21512
更新日期:2013-06-01 00:00:00