Abstract:
:Here, we ask whether frontotemporal cortex is functionally dissociated into distributed lexical and category-specific semantic networks. To this end, fMRI activation patterns elicited during the processing of words from different semantic categories were categorized using k-means cluster algorithms. Results showed a distributed pattern of inferiorfrontal, superiortemporal, and fusiform activation shared by different word categories. This shared activation contrasted with patterns of category-specific semantic activation in widely distributed neural systems. Clustering revealed congruent functional specificity of focal area activations in frontal and temporal cortex; thus suggesting a correspondence between functional partitionings of frontocentral mirror neuron systems and those of inferiortemporal lexical and semantic circuits. Action words related to the face, arms, and legs specifically activated the motor system in a somatotopic manner, whereas form-related words activated prefrontal areas. Similar functional specificity was evident in temporal cortex, where a different semantic topography emerged for form- and action-related words. Results were replicated in a separate data set, therefore recommending fMRI cluster analysis as a reliable method for scrutinizing the brain basis of lexical, semantic, and conceptual systems in humans. As focal modules do not explain the distributed character of functionally specific clusters and their distinct topographies are at variance with general distributed processing accounts, the functionally-homogenous distributed clusters specific to semantic types are best explained by specifically-distributed cortical circuits which, similar to Hebbian cell assemblies, represent functional units with specific roles in cognitive processing, especially in lexical and semantic access and memory.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Pulvermüller F,Kherif F,Hauk O,Mohr B,Nimmo-Smith Idoi
10.1002/hbm.20811subject
Has Abstractpub_date
2009-12-01 00:00:00pages
3837-50issue
12eissn
1065-9471issn
1097-0193journal_volume
30pub_type
杂志文章abstract::The BrainMap database is a community resource that curates peer-reviewed, coordinate-based human neuroimaging literature. By pairing the results of neuroimaging studies with their relevant meta-data, BrainMap facilitates coordinate-based meta-analysis (CBMA) of the neuroimaging literature en masse or at the level of e...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24078
更新日期:2018-08-01 00:00:00
abstract::Recently, it has been suggested that backwardly masked, and thus subliminally presented, fearful eyes are processed by the amygdala. Here, we investigated in four functional magnetic resonance imaging experiments whether the amygdala responds to subliminally presented fearful eyes per se or whether an interaction of m...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20960
更新日期:2010-10-01 00:00:00
abstract::The hippocampus, a hub of activity for a variety of important cognitive processes, is a target of increasing interest for researchers and clinicians. Magnetoencephalography (MEG) is an attractive technique for imaging spectro-temporal aspects of function, for example, neural oscillations and network timing, especially...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24445
更新日期:2019-03-01 00:00:00
abstract::Research using the Stop Signal Task employing an adaptive algorithm to accommodate individual differences often report inferior performance on the task in individuals with ADHD, OCD, and substance use disorders compared to non-clinical controls. Furthermore, individuals with deficits in inhibitory control tend to show...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24075
更新日期:2018-08-01 00:00:00
abstract::Verbal irony conveys various emotional messages, from criticism to humor, that differ from the meaning of the actual words. To understand irony, we need conceptual knowledge of irony in addition to an understanding of context. We investigated the neural mechanism of irony comprehension, focusing on two overlooked issu...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22242
更新日期:2014-04-01 00:00:00
abstract::The central extended amygdala (EAc)-including the bed nucleus of the stria terminalis (BST) and central nucleus of the amygdala (Ce)-plays a critical role in triggering fear and anxiety and is implicated in the development of a range of debilitating neuropsychiatric disorders. Although it is widely believed that these...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23917
更新日期:2018-03-01 00:00:00
abstract::The goal of this study was to document current clinical practice and report patient outcomes in presurgical language functional MRI (fMRI) for epilepsy surgery. Epilepsy surgical programs worldwide were surveyed as to the utility, implementation, and efficacy of language fMRI in the clinic; 82 programs responded. Resp...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24039
更新日期:2018-07-01 00:00:00
abstract::We describe a system that localizes a single dipole to reasonable accuracy from noisy magnetoencephalographic (MEG) measurements in real time. At its core is a multilayer perceptron (MLP) trained to map sensor signals and head position to dipole location. Including head position overcomes the previous need to retrain ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20068
更新日期:2005-01-01 00:00:00
abstract::Characterizing the neurovascular coupling between hemodynamic signals and their neural origins is crucial to functional neuroimaging research, even more so as new methods become available for integrating results from different functional neuroimaging modalities. We present a novel method to relate magnetoencephalograp...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20361
更新日期:2008-01-01 00:00:00
abstract::The acquisition of functional magnetic resonance imaging (fMRI) data in a finite subset of k-space produces ring-artifacts and 'side lobes' that distort the image. In this article, we explore the consequences of this problem for functional imaging studies, which can be considerable, and propose a solution. The truncat...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20475
更新日期:2008-11-01 00:00:00
abstract::Simultaneous Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) scanning is a recent major development in biomedical imaging. The full integration of the PET detector ring and electronics within the MR system has been a technologically challenging design to develop but provides capacity for simult...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.24314
更新日期:2018-12-01 00:00:00
abstract::Individuals often have reduced ability to hear alarms in real world situations (e.g., anesthesia monitoring, flying airplanes) when attention is focused on another task, sometimes with devastating consequences. This phenomenon is called inattentional deafness and usually occurs under critical high workload conditions....
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24026
更新日期:2018-06-01 00:00:00
abstract::Surprise drives learning. Various neural "prediction error" signals are believed to underpin surprise-based reinforcement learning. Here, we report a surprise signal that reflects reinforcement learning but is neither un/signed reward prediction error (RPE) nor un/signed state prediction error (SPE). To exclude these ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22513
更新日期:2014-09-01 00:00:00
abstract::Fast cancellation or switching of action plans is a critical cognitive function. Rapid signal transmission is key for quickly executing and inhibiting responses, and the structural integrity of connections between brain regions plays a crucial role in signal transmission speed. In this study, we used the search-step t...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23209
更新日期:2016-08-01 00:00:00
abstract::Diffusion tensor imaging (DTI) can be used to index white matter integrity of the corticospinal tract (CST) after stroke; however, the psychometric properties of DTI-based measures of white matter integrity are unknown. The purpose of this study was to examine test-retest reliability as determined by intraclass correl...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24961
更新日期:2020-06-15 00:00:00
abstract::The reason why human beings are inclined to overestimate the duration of highly arousing negative events remains enigmatic. The issue about what neurocognitive mechanisms and neural structures support the connection between time perception and emotion was addressed here by an event-related neuroimaging study involving...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22680
更新日期:2015-03-01 00:00:00
abstract::Reproducibility is one of the most important issues for generalizing the results of clinical research; however, low reproducibility in neuroimaging studies is well known. To overcome this problem, the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium, an international neuroimaging consortium, e...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.25040
更新日期:2020-06-05 00:00:00
abstract:BACKGROUND:Abnormalities in inhibitory control and underlying fronto-striatal networks is common to both attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive-disorder (OCD). The aim of this study was to investigate disorder-specific abnormalities in neural networks mediating interference inhibition ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21048
更新日期:2011-04-01 00:00:00
abstract:UNLABELLED:Major depression has been repeatedly associated with amygdala hyper-responsiveness to negative (but not positive) facial expressions at early, automatic stages of emotion processing using subliminally presented stimuli. However, it is not clear whether this "limbic bias" is a correlate of depression or repre...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22112
更新日期:2013-11-01 00:00:00
abstract::Humans can easily recognize others' facial expressions. Among the brain substrates that enable this ability, considerable attention has been paid to face-selective areas; in contrast, whether motion-sensitive areas, which clearly exhibit sensitivity to facial movements, are involved in facial expression recognition re...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23578
更新日期:2017-06-01 00:00:00
abstract::In depression, patients suffer from emotional and cognitive deficits, among others in semantic processing. If these semantic deficits are cognitive or interact with emotional dysfunctions, is still an open question. The aim of the current study was to investigate the influence of emotional valence on the neural correl...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22186
更新日期:2014-02-01 00:00:00
abstract::Recently, blink-related delta oscillations (delta BROs) have been observed in healthy subjects during spontaneous blinking at rest. Delta BROs have been linked with continuous gathering of information from the surrounding environment, which is classically attributed to the precuneus. Furthermore, fMRI studies have sho...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22056
更新日期:2013-09-01 00:00:00
abstract::Increased cerebral blood flow in the anterior cingulate cortex (ACC) has been noted in a range of cognitively demanding tasks studied with PET. A PET study of 10 normal males was carried out using the bolus H2(15)O intravenous injection technique to examine the effects of anticipation on blood flow to the ACC. In a se...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1996)4:2<103::AID-HBM2>3.0
更新日期:1996-01-01 00:00:00
abstract::Musical expertise is visible both in the morphology and functionality of the brain. Recent research indicates that functional integration between multi-sensory, somato-motor, default-mode (DMN), and salience (SN) networks of the brain differentiates musicians from non-musicians during resting state. Here, we aimed at ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23565
更新日期:2017-06-01 00:00:00
abstract::In contrast to conventional functional magnetic resonance imaging (fMRI) analysis across participants, item analysis allows generalizing the observed neural response patterns from a specific stimulus set to the entire population of stimuli. In the present study, we perform an item analysis on an fMRI paradigm (EmpaToM...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24966
更新日期:2020-07-01 00:00:00
abstract::There is good evidence from animal studies for segregation in the processing of non-nociceptive and nociceptive information within the trigeminal brainstem sensory nuclear complex. However, it remains unknown whether a similar segregation occurs in humans, and a recent tract tracing study suggests that this segregatio...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20805
更新日期:2009-11-01 00:00:00
abstract::This paper describes a Bayesian method for three-dimensional registration of brain images. A finite element approach is used to obtain a maximum a posteriori estimate of the deformation field at every voxel of a template volume. The priors used by the MAP estimate penalize unlikely deformations and enforce a continuou...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(sici)1097-0193(200004)9:4<212::aid-hbm3>3
更新日期:2000-04-01 00:00:00
abstract::In day-to-day life, we need to apply strategies to cascade different actions for efficient unfolding of behavior. While deficits in action cascading are examined extensively, almost nothing is known about the neuronal mechanisms mediating superior performance above the normal level. To examine this question, we invest...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22530
更新日期:2014-10-01 00:00:00
abstract::There is substantial variability in speech recognition ability across patients with cochlear implants (CIs), auditory brainstem implants (ABIs), and auditory midbrain implants (AMIs). To better understand how this variability is related to central processing differences, the current electroencephalography (EEG) study ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23515
更新日期:2017-04-01 00:00:00
abstract::Simultaneous electroencephalography and functional magnetic resonance imaging (EEG/fMRI) have been proposed to contribute to the definition of the epileptic seizure onset zone. Following interictal epileptiform discharges, one usually assumes a canonical hemodynamic response function (HRF), which has been derived from...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20925
更新日期:2010-08-01 00:00:00