当前位置： SCI文献检索 > HUMAN BRAIN MAPPING期刊下所有文献 > Childhood maltreatment is associated with an automatic negative emotion processing bias in the amygdala.

Childhood maltreatment is associated with an automatic negative emotion processing bias in the amygdala.

Abstract：

UNLABELLED:Major depression has been repeatedly associated with amygdala hyper-responsiveness to negative (but not positive) facial expressions at early, automatic stages of emotion processing using subliminally presented stimuli. However, it is not clear whether this "limbic bias" is a correlate of depression or represents a vulnerability marker preceding the onset of the disease. Because childhood maltreatment is a potent risk factor for the development of major depression in later life, we explored whether childhood maltreatment is associated with amygdalar emotion processing bias in maltreated but healthy subjects. Amygdala responsiveness to subliminally presented sad and happy faces was measured by means of fMRI at 3 T in N = 150 healthy subjects carefully screened for psychiatric disorders. Childhood maltreatment was assessed by the 25-item childhood trauma questionnaire (CTQ). A strong association of CTQ-scores with amygdala responsiveness to sad, but not happy facial expressions emerged. This result was further qualified by an interaction of emotional valence and CTQ-scores and was not confounded by trait anxiety, current depression level, age, gender, intelligence, education level, and more recent stressful life-events. Childhood maltreatment is apparently associated with detectable changes in amygdala function during early stages of emotion processing which resemble findings described in major depression. Limbic hyper-responsiveness to negative facial cues could be a consequence of the experience of maltreatment during childhood increasing the risk of depression in later life. LIMITATION:the present association of limbic bias and maltreatment was demonstrated in the absence of psychopathological abnormalities, thereby limiting strong conclusions.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Dannlowski U,Kugel H,Huber F,Stuhrmann A,Redlich R,Grotegerd D,Dohm K,Sehlmeyer C,Konrad C,Baune BT,Arolt V,Heindel W,Zwitserlood P,Suslow T

doi

10.1002/hbm.22112

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

2899-909

issue

eissn

1065-9471

issn

1097-0193

journal_volume

pub_type

杂志文章

在线工具

Childhood maltreatment is associated with an automatic negative emotion processing bias in the amygdala.