Abstract:
:The recent ability to measure in vivo beta-amyloid (Aβ), a marker of Alzheimer's disease (AD), has led to an increased focus on the significance of Aβ deposition in clinically normal adults. Evidence suggests that healthy adults with elevated cortical Aβ show differences in neural activity associated with memory encoding-specifically encoding of face stimuli. Here, we examined if Aβ deposition in clinically normal adults was related to differences in neural activity in ventral visual cortex during face viewing. Our sample included 23 high-Aβ older adults, 23 demographically matched low-Aβ older adults, and 16 young adults. Participants underwent cognitive testing, Aβ positron emission tomography imaging with (18) F-Florbetapir, and functional magnetic resonance imaging to measure neural activity while participants passively viewed photographs of faces. Using barycentric discriminant analysis-a between-groups classification technique-we found that patterns of neural activity in the left fusiform gyrus, a region highly responsive to faces, distinguished Aβ status of participants. Older adults with elevated Aβ were characterized by decreased activity in left fusiform compared to Aβ-negative older adults. Further, we found that the degree to which older adults expressed decreased fusiform activity was related to worse performance on tasks of processing speed. Our results provide unique evidence that, in addition to previously studied memory and default regions, decreased neural activity in a region important for face perception was associated with elevated Aβ and may be an early manifestation of AD.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Rieck JR,Rodrigue KM,Kennedy KM,Devous MD Sr,Park DCdoi
10.1002/hbm.22788subject
Has Abstractpub_date
2015-07-01 00:00:00pages
2514-26issue
7eissn
1065-9471issn
1097-0193journal_volume
36pub_type
杂志文章abstract::The framework of assimilation and accommodation has been proposed to explain the brain mechanisms supporting second language reading acquisition (Perfetti et al. [2007]: Bilingual Lang Cogn 10:131). Assimilation refers to using the procedures of the native language network in the acquisition of a new writing system, w...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22904
更新日期:2015-10-01 00:00:00
abstract::The Stroop interference test requires a person to respond to specific elements of a stimulus while suppressing a competing response. Previous positron emission tomography (PET) work has shown increased activity in the right anterior cingulate gyrus during the Stroop test. It is unclear, however, whether the anterior c...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.460010305
更新日期:1994-01-01 00:00:00
abstract::The presence of white matter lesions in patients with cerebral small vessel disease (SVD) is among the main causes of cognitive decline. We investigated the relation between white matter hyperintensity (WMH) locations and executive and language abilities in 442 SVD patients without dementia with varying burden of WMH....
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25273
更新日期:2020-11-24 00:00:00
abstract::Brain morphometry based classification from magnetic resonance (MR) acquisitions has been widely investigated in the diagnosis of Alzheimer's disease (AD) and its prodromal stage, i.e., mild cognitive impairment (MCI). In the literature, a morphometric representation of brain structures is obtained by spatial normaliz...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22531
更新日期:2014-10-01 00:00:00
abstract::Most of the previous task functional magnetic resonance imaging (fMRI) studies found abnormalities in distributed brain regions in mild cognitive impairment (MCI) and Alzheimer's disease (AD), and few studies investigated the brain network dysfunction from the system level. In this meta-analysis, we aimed to examine b...
journal_title:Human brain mapping
pub_type: 杂志文章,meta分析,评审
doi:10.1002/hbm.22689
更新日期:2015-03-01 00:00:00
abstract::Task-switching performance relies on a broadly distributed frontoparietal network and declines in older adults. In this study, they investigated whether this age-related decline in task switching performance was mediated by variability in global or regional white matter microstructural health. Seventy cognitively inta...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23473
更新日期:2017-03-01 00:00:00
abstract::This study investigated the cortical responses underlying magnitude comparisons of multisensory stimuli and examined the effect that musical expertise has in this process. The comparative judgments were based on a newly learned rule binding the auditory and visual stimuli within the context of magnitude comparisons: "...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22558
更新日期:2014-11-01 00:00:00
abstract::Previous findings have shown that the human somatosensory cortical systems that are activated by passive nonpainful electrical stimulation include the contralateral primary somatosensory area (SI), bilateral secondary somatosensory area (SII), and bilateral insula. The present study tested the hypothesis that these ar...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20292
更新日期:2007-07-01 00:00:00
abstract::The central extended amygdala (EAc)-including the bed nucleus of the stria terminalis (BST) and central nucleus of the amygdala (Ce)-plays a critical role in triggering fear and anxiety and is implicated in the development of a range of debilitating neuropsychiatric disorders. Although it is widely believed that these...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23917
更新日期:2018-03-01 00:00:00
abstract::Functional imaging studies consistently find that emotional stimuli activate the posterior cingulate cortex, a region that appears to have memory-related functions. However, prior imaging studies have not controlled for non-emotional stimulus features that might activate this region by engaging memory processes unrela...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.10075
更新日期:2003-01-01 00:00:00
abstract::Although neural signals of reward anticipation have been studied extensively, the functional relationship between reward and attention has remained unclear: Neural signals implicated in reward processing could either reflect attentional biases towards motivationally salient stimuli, or proceed independently of attenti...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22383
更新日期:2014-07-01 00:00:00
abstract::We describe a method for the statistical parametric mapping of low resolution electromagnetic tomography (LORETA) using high-density electroencephalography (EEG) and individual magnetic resonance images (MRI) to investigate the characteristics of the mismatch negativity (MMN) generators in schizophrenia. LORETA, using...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.10059
更新日期:2002-11-01 00:00:00
abstract::Working memory (WM) is defined as the ability to maintain a representation online to guide goal-directed behavior. Its capacity in early childhood predicts academic achievements in late childhood and its deficits are found in various neurodevelopmental disorders. We employed resting-state fMRI (rs-fMRI) of 468 partici...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25143
更新日期:2020-11-01 00:00:00
abstract::Human brain mapping allows the systematic assessment of interindividual differences in functional brain anatomy. Functional transcranial Doppler sonography (fTCD) is an imaging tool that allows for fast and mobile assessment of hemispheric lateralization of task-related brain activation. It is ideal to screen large co...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20055
更新日期:2004-11-01 00:00:00
abstract::Resection of the seizure generating tissue can be highly beneficial in patients with drug-resistant epilepsy. However, only about half of all patients undergoing surgery get permanently and completely seizure free. Investigating the dependences between intracranial EEG signals adds a multivariate perspective largely u...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24816
更新日期:2020-02-01 00:00:00
abstract::Current neuroscientific research has shown that the brain reconfigures its functional interactions at multiple timescales. Here, we sought to link transient changes in functional brain networks to individual differences in behavioral and cognitive performance by using an active learning paradigm. Participants learned ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23285
更新日期:2016-11-01 00:00:00
abstract::Previous investigations of the default-mode network (DMN) in persons with attention-deficit/hyperactivity disorder (ADHD) have shown reduced functional connectivity between the anterior and posterior aspects. This finding was originally demonstrated in adults with ADHD, then in youth with ADHD, and has been tentativel...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21459
更新日期:2013-03-01 00:00:00
abstract::To test a prediction of our previous computational model of cortico-hippocampal interaction (Gluck and Myers [1993, 2001]) for characterizing individual differences in category learning, we studied young healthy subjects using an fMRI-adapted category-learning task that has two phases, an initial phase in which associ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22389
更新日期:2014-07-01 00:00:00
abstract::Classically, model-based segmentation procedures match magnetic resonance imaging (MRI) volumes to an expertly labeled atlas using nonlinear registration. The accuracy of these techniques are limited due to atlas biases, misregistration, and resampling error. Multi-atlas-based approaches are used as a remedy and invol...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22092
更新日期:2013-10-01 00:00:00
abstract::Recent research found lasting increases in personality trait Openness in healthy individuals and patients after administration of the serotonin 2A receptor (5-HT2A R) agonist psilocybin. However, no studies have investigated whether 5-HT2A R availability as imaged using positron emission tomography (PET) is associated...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24511
更新日期:2019-05-01 00:00:00
abstract::White matter (WM) microstructure, as determined by diffusion tensor imaging (DTI), is increasingly recognized as an important determinant of cognitive function and is also altered in neuropsychiatric disorders. Little is known about genetic and environmental influences on WM microstructure, especially in early childho...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24436
更新日期:2019-03-01 00:00:00
abstract::Neuroimaging investigations consistently demonstrate that the neural processes involve complex interactions between the large-scale networks. Among those networks, the dorsal attention network (DAN) and the central-executive network (CEN) have been previously shown to exhibit anti-correlated activity with the default-...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24339
更新日期:2018-12-01 00:00:00
abstract::Humans take a long time to respond to the slow visual motion of an object. It is not known what neural mechanism causes this delay. We measured magnetoencephalographic neural responses to light spot motion onset within a wide speed range (0.4-500 degrees /sec) and compared these with human reaction times (RTs). The me...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.10033
更新日期:2002-06-01 00:00:00
abstract::During complex tasks, patterns of functional connectivity differ from those in the resting state. However, what accounts for such differences remains unclear. Brain activity during a task reflects an unknown mixture of spontaneous and task-evoked activities. The difference in functional connectivity between a task sta...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24335
更新日期:2018-12-01 00:00:00
abstract::The histaminergic involvement in selective processes underlying its role in human sensori-motor performance is largely unknown. Recently, selective effects of central H₁-inverse agonism on sensory visual processes were observed in electrophysiological--but not behavioral data; a discrepancy suggested to result from sp...
journal_title:Human brain mapping
pub_type: 杂志文章,随机对照试验
doi:10.1002/hbm.22387
更新日期:2014-07-01 00:00:00
abstract::The action observation network (AON) is supposed to play a crucial role when athletes anticipate the effect of others' actions in sports such as tennis. We used functional magnetic resonance imaging to explore whether motor expertise leads to a differential activation pattern within the AON during effect anticipation ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22455
更新日期:2014-08-01 00:00:00
abstract::A persistent problem in developing plausible neurophysiological models of perception, cognition, and action is the difficulty of characterizing the interactions between different neural systems. Previous studies have approached this problem by estimating causal influences across brain areas activated during cognitive ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20772
更新日期:2009-06-01 00:00:00
abstract::Low socioeconomic status (SES) is associated with a higher probability of multiple exposures (e.g., neighborhood violence, poor nutrition, housing instability, air pollution, and insensitive caregiving) known to affect structural development of subcortical brain regions that subserve threat and reward processing, howe...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24796
更新日期:2020-01-01 00:00:00
abstract::Previous whole-brain functional connectivity studies achieved successful classifications of patients and healthy controls but only offered limited specificity as to affected brain systems. Here, we examined whether the connectivity patterns of functional systems affected in schizophrenia (SCZ), Parkinson's disease (PD...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23763
更新日期:2017-12-01 00:00:00
abstract::Despite the clinical significance of event-related potential (ERP) latency abnormalities, little attention has focused on the anatomic substrate of latency variability. Volume conduction models do not identify the anatomy responsible for delayed neural transmission between neural sources. To explore the anatomic subst...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20103
更新日期:2005-07-01 00:00:00