Abstract:
:Most of the previous task functional magnetic resonance imaging (fMRI) studies found abnormalities in distributed brain regions in mild cognitive impairment (MCI) and Alzheimer's disease (AD), and few studies investigated the brain network dysfunction from the system level. In this meta-analysis, we aimed to examine brain network dysfunction in MCI and AD. We systematically searched task-based fMRI studies in MCI and AD published between January 1990 and January 2014. Activation likelihood estimation meta-analyses were conducted to compare the significant group differences in brain activation, the significant voxels were overlaid onto seven referenced neuronal cortical networks derived from the resting-state fMRI data of 1,000 healthy participants. Thirty-nine task-based fMRI studies (697 MCI patients and 628 healthy controls) were included in MCI-related meta-analysis while 36 task-based fMRI studies (421 AD patients and 512 healthy controls) were included in AD-related meta-analysis. The meta-analytic results revealed that MCI and AD showed abnormal regional brain activation as well as large-scale brain networks. MCI patients showed hypoactivation in default, frontoparietal, and visual networks relative to healthy controls, whereas AD-related hypoactivation mainly located in visual, default, and ventral attention networks relative to healthy controls. Both MCI-related and AD-related hyperactivation fell in frontoparietal, ventral attention, default, and somatomotor networks relative to healthy controls. MCI and AD presented different pathological while shared similar compensatory large-scale networks in fulfilling the cognitive tasks. These system-level findings are helpful to link the fundamental declines of cognitive tasks to brain networks in MCI and AD.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Li HJ,Hou XH,Liu HH,Yue CL,He Y,Zuo XNdoi
10.1002/hbm.22689subject
Has Abstractpub_date
2015-03-01 00:00:00pages
1217-32issue
3eissn
1065-9471issn
1097-0193journal_volume
36pub_type
杂志文章,meta分析,评审abstract:OBJECTIVE:To assess the structural correlates of cognitive and behavioral impairment in motor neuron diseases (MND) using multimodal MRI. METHODS:One hundred one patients with sporadic MND (56 classic amyotrophic lateral sclerosis, 31 upper motor neuron phenotype, and 14 lower motor neuron phenotype) and 51 controls w...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23124
更新日期:2016-04-01 00:00:00
abstract::Everyday communication is accompanied by visual information from several sources, including co-speech gestures, which provide semantic information listeners use to help disambiguate the speaker's message. Using fMRI, we examined how gestures influence neural activity in brain regions associated with processing semanti...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20774
更新日期:2009-11-01 00:00:00
abstract::BOLD functional MRI (fMRI) data are dominated by low frequency signals, many of them of unclear origin. We have recently shown that some portions of the low frequency oscillations found in BOLD fMRI are systemic signals closely related to the blood circulation (Tong et al. [2013]: NeuroImage 76:202-215). They are comm...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22564
更新日期:2014-11-01 00:00:00
abstract::Playing music requires a strong coupling of perception and action mediated by multimodal integration of brain regions, which can be described as network connections measured by anatomical and functional correlations between regions. However, the structural and functional connectivities within and between the auditory ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23989
更新日期:2018-05-01 00:00:00
abstract::Magnetoencephalographic (MEG) investigations of inter-regional amplitude correlations have yielded new insights into the organization and neurophysiology of resting-state networks (RSNs) first identified using fMRI. Inter-regional MEG amplitude correlations in adult RSNs have been shown to be most prominent in alpha a...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22547
更新日期:2014-10-01 00:00:00
abstract::Parkinson's disease (PD) is characterized by overlapping motor, neuropsychiatric, and cognitive symptoms. Worse performance in one domain is associated with worse performance in the other domains. Commonality analysis (CA) is a method of variance partitioning in multiple regression, used to separate the specific and c...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25084
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:Poor decision-making is a hallmark of addiction, whether to substances or activities. Performance on a widely used test of decision-making, the Iowa Gambling Task (IGT), can discriminate controls from persons with ventral medial frontal lesions, substance-dependence, and pathological gambling. Positron emissi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20344
更新日期:2007-12-01 00:00:00
abstract::MR-based measurements of brain volumes may be affected by the presence of white matter (WM) lesions. Here, we assessed how and to what extent this may happen for WM lesions of various sizes and intensities. After inserting WM lesions of different sizes and intensities into T1-W brain images of healthy subjects, we ass...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21344
更新日期:2012-09-01 00:00:00
abstract::This fMRI study investigated brain activity while soccer players were imagining creative moves in real soccer decision-making situations. After presenting brief video clips of a soccer scene, participants had to imagine themselves as the acting player and think either of a creative or obvious move that might lead to a...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24408
更新日期:2019-02-15 00:00:00
abstract::To generate imaging biomarkers from disease-specific brain networks, we have implemented a general toolbox to rapidly perform scaled subprofile modeling (SSM) based on principal component analysis (PCA) on brain images of patients and normals. This SSMPCA toolbox can define spatial covariance patterns whose expression...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22295
更新日期:2014-05-01 00:00:00
abstract::There have been many functional imaging studies of the brain basis of theory of mind (ToM) skills, but the findings are heterogeneous and implicate anatomical regions as far apart as orbitofrontal cortex and the inferior parietal lobe. The functional imaging studies are reviewed to determine whether the diverse findin...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.20671
更新日期:2009-08-01 00:00:00
abstract::Cross-modal processing enables the utilization of information received via different sensory organs to facilitate more complicated human actions. We used functional MRI on early-blind individuals to study the neural processes associated with cross auditory-spatial learning. The auditory signals, converted from echoes ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21395
更新日期:2012-11-01 00:00:00
abstract::There is a great individual variability for acquiring syntactic knowledge in a second language (L2). Little is, however, known if there is any anatomical basis in the brain for individual differences in syntactic acquisition. Here we examined brain structures in 95 nonnative speakers of English, including 78 high-scho...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20790
更新日期:2009-11-01 00:00:00
abstract::Cortical surface templates are an important standardized coordinate frame for cortical structure and function analysis in magnetic resonance (MR) imaging studies. The widely used adult cortical surface templates (e.g., fsaverage, Conte69, and the HCP-MMP atlas) are based on the Caucasian population. Neuroanatomical di...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24960
更新日期:2020-06-15 00:00:00
abstract::Demyelination and axonal damage are pathologic hallmarks of multiple sclerosis (MS), leading to loss of neuronal synchronization, functional disconnection amongst brain relays, and clinical sequelae. To investigate these properties, the primary component of the sensorimotor network was analyzed in mildly disabled Rela...
journal_title:Human brain mapping
pub_type: 杂志文章,随机对照试验
doi:10.1002/hbm.20961
更新日期:2010-10-01 00:00:00
abstract::In contrast to conventional functional magnetic resonance imaging (fMRI) analysis across participants, item analysis allows generalizing the observed neural response patterns from a specific stimulus set to the entire population of stimuli. In the present study, we perform an item analysis on an fMRI paradigm (EmpaToM...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24966
更新日期:2020-07-01 00:00:00
abstract::Infants born prematurely are at increased risk of adverse neurodevelopmental outcome. The measurement of white matter tissue composition and structure can help predict functional performance. Specifically, measurements of myelination and indicators of myelination status in the preterm brain could be predictive of late...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23188
更新日期:2016-07-01 00:00:00
abstract::The literature points to a large distributed brain network involved in the estimation of time. Among these regions, the role of the insular cortex is still poorly understood. At the confluence of emotional, interoceptive, and environmental signals, this brain structure has been proposed to underlie awareness of the pa...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24460
更新日期:2019-04-01 00:00:00
abstract::Although neural signals of reward anticipation have been studied extensively, the functional relationship between reward and attention has remained unclear: Neural signals implicated in reward processing could either reflect attentional biases towards motivationally salient stimuli, or proceed independently of attenti...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22383
更新日期:2014-07-01 00:00:00
abstract::High-density electrical mapping of event-related potentials was used to investigate the neural processes that permit some elderly subjects to preserve high levels of executive functioning. Two possibilities pertain: (1) high-performance in elderly subjects is underpinned by similar processing mechanisms to those seen ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20839
更新日期:2009-12-01 00:00:00
abstract::There are several types of experiment in which it is useful to have subjects speak overtly in a magnetic resonance imaging (MRI) scanner, including those studying the articulatory apparatus and the neural basis of speech production, and fMRI experiments in which speech is used as a response modality. Although it is re...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20085
更新日期:2005-04-01 00:00:00
abstract::Brain plasticity and memory formation depend on the expression of a large number of genes. This relationship had been studied using several experimental approaches and researchers have identified genes regulating plasticity through a variety of mechanisms. Despite this effort, a great deal remains unknown regarding th...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22592
更新日期:2014-12-01 00:00:00
abstract::The hypothalamus is of enormous importance for multiple bodily functions such as energy homeostasis. Especially, rodent studies have greatly contributed to our understanding how specific hypothalamic subregions integrate peripheral and central signals into the brain to control food intake. In humans, however, the neur...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22607
更新日期:2014-12-01 00:00:00
abstract::Before considering a given fMRI paradigm as a valid clinical tool, one should first assess the reliability of functional responses across subjects by establishing a normative database and defining a reference activation map that identifies major brain regions involved in the task at hand. However, the definition of su...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20410
更新日期:2008-04-01 00:00:00
abstract::Adverse childhood experiences (ACEs) have been acknowledged as risk factors for increased mental health complications in adulthood, specifically increasing susceptibility to developing psychopathology upon exposure to trauma. Yet, little is known regarding the impact of mild ACEs on highly functioning population. In t...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25246
更新日期:2021-02-15 00:00:00
abstract::The deviation between chronological age and age predicted using brain MRI is a putative marker of overall brain health. Age prediction based on structural MRI data shows high accuracy in common brain disorders. However, brain aging is complex and heterogenous, both in terms of individual differences and the underlying...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25323
更新日期:2020-12-19 00:00:00
abstract::The registration of image volumes derived from different imaging modalities such as MRI, PET, SPECT, and CT has been described in numerous studies in which functional and morphological data are combined on the basis of macrostructural information. However, the exact topography of architectural details is defined by mi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::We present a novel, computerized method of examining cerebral cortical thickness. The normal cortex varies in thickness from 2 to 4 mm, reflecting the morphology of neuronal sublayers. Cortical pathologies often manifest abnormal variations in thickness, with examples of Alzheimer's disease and cortical dysplasia as t...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/1097-0193(200009)11:1<12::aid-hbm20>3.0.co
更新日期:2000-09-01 00:00:00
abstract::Current knowledge about small-world networks underlying emotions is sparse, and confined to functional magnetic resonance imaging (fMRI) studies using resting-state paradigms. This fMRI study applied Eigenvector Centrality Mapping (ECM) and functional connectivity analysis to reveal neural small-world networks underly...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22416
更新日期:2014-07-01 00:00:00
abstract::During the last 20 years, predictive modeling in epilepsy research has largely been concerned with the prediction of seizure events, whereas the inference of effective brain targets for resective surgery has received surprisingly little attention. In this exploratory pilot study, we describe a distributional clusterin...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23537
更新日期:2017-05-01 00:00:00