Toward systems neuroscience in mild cognitive impairment and Alzheimer's disease: a meta-analysis of 75 fMRI studies.

Abstract:

:Most of the previous task functional magnetic resonance imaging (fMRI) studies found abnormalities in distributed brain regions in mild cognitive impairment (MCI) and Alzheimer's disease (AD), and few studies investigated the brain network dysfunction from the system level. In this meta-analysis, we aimed to examine brain network dysfunction in MCI and AD. We systematically searched task-based fMRI studies in MCI and AD published between January 1990 and January 2014. Activation likelihood estimation meta-analyses were conducted to compare the significant group differences in brain activation, the significant voxels were overlaid onto seven referenced neuronal cortical networks derived from the resting-state fMRI data of 1,000 healthy participants. Thirty-nine task-based fMRI studies (697 MCI patients and 628 healthy controls) were included in MCI-related meta-analysis while 36 task-based fMRI studies (421 AD patients and 512 healthy controls) were included in AD-related meta-analysis. The meta-analytic results revealed that MCI and AD showed abnormal regional brain activation as well as large-scale brain networks. MCI patients showed hypoactivation in default, frontoparietal, and visual networks relative to healthy controls, whereas AD-related hypoactivation mainly located in visual, default, and ventral attention networks relative to healthy controls. Both MCI-related and AD-related hyperactivation fell in frontoparietal, ventral attention, default, and somatomotor networks relative to healthy controls. MCI and AD presented different pathological while shared similar compensatory large-scale networks in fulfilling the cognitive tasks. These system-level findings are helpful to link the fundamental declines of cognitive tasks to brain networks in MCI and AD.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Li HJ,Hou XH,Liu HH,Yue CL,He Y,Zuo XN

doi

10.1002/hbm.22689

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

1217-32

issue

3

eissn

1065-9471

issn

1097-0193

journal_volume

36

pub_type

杂志文章,meta分析,评审
  • Structural brain correlates of cognitive and behavioral impairment in MND.

    abstract:OBJECTIVE:To assess the structural correlates of cognitive and behavioral impairment in motor neuron diseases (MND) using multimodal MRI. METHODS:One hundred one patients with sporadic MND (56 classic amyotrophic lateral sclerosis, 31 upper motor neuron phenotype, and 14 lower motor neuron phenotype) and 51 controls w...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23124

    authors: Agosta F,Ferraro PM,Riva N,Spinelli EG,Chiò A,Canu E,Valsasina P,Lunetta C,Iannaccone S,Copetti M,Prudente E,Comi G,Falini A,Filippi M

    更新日期:2016-04-01 00:00:00

  • Co-speech gestures influence neural activity in brain regions associated with processing semantic information.

    abstract::Everyday communication is accompanied by visual information from several sources, including co-speech gestures, which provide semantic information listeners use to help disambiguate the speaker's message. Using fMRI, we examined how gestures influence neural activity in brain regions associated with processing semanti...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20774

    authors: Dick AS,Goldin-Meadow S,Hasson U,Skipper JI,Small SL

    更新日期:2009-11-01 00:00:00

  • Tracking cerebral blood flow in BOLD fMRI using recursively generated regressors.

    abstract::BOLD functional MRI (fMRI) data are dominated by low frequency signals, many of them of unclear origin. We have recently shown that some portions of the low frequency oscillations found in BOLD fMRI are systemic signals closely related to the blood circulation (Tong et al. [2013]: NeuroImage 76:202-215). They are comm...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22564

    authors: Tong Y,Frederick Bd

    更新日期:2014-11-01 00:00:00

  • Musical training induces functional and structural auditory-motor network plasticity in young adults.

    abstract::Playing music requires a strong coupling of perception and action mediated by multimodal integration of brain regions, which can be described as network connections measured by anatomical and functional correlations between regions. However, the structural and functional connectivities within and between the auditory ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23989

    authors: Li Q,Wang X,Wang S,Xie Y,Li X,Xie Y,Li S

    更新日期:2018-05-01 00:00:00

  • Oscillations, networks, and their development: MEG connectivity changes with age.

    abstract::Magnetoencephalographic (MEG) investigations of inter-regional amplitude correlations have yielded new insights into the organization and neurophysiology of resting-state networks (RSNs) first identified using fMRI. Inter-regional MEG amplitude correlations in adult RSNs have been shown to be most prominent in alpha a...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22547

    authors: Schäfer CB,Morgan BR,Ye AX,Taylor MJ,Doesburg SM

    更新日期:2014-10-01 00:00:00

  • Common and unique connectivity at the interface of motor, neuropsychiatric, and cognitive symptoms in Parkinson's disease: A commonality analysis.

    abstract::Parkinson's disease (PD) is characterized by overlapping motor, neuropsychiatric, and cognitive symptoms. Worse performance in one domain is associated with worse performance in the other domains. Commonality analysis (CA) is a method of variance partitioning in multiple regression, used to separate the specific and c...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.25084

    authors: Lang S,Ismail Z,Kibreab M,Kathol I,Sarna J,Monchi O

    更新日期:2020-09-01 00:00:00

  • Prefrontal cortex activity is reduced in gambling and nongambling substance users during decision-making.

    abstract:OBJECTIVE:Poor decision-making is a hallmark of addiction, whether to substances or activities. Performance on a widely used test of decision-making, the Iowa Gambling Task (IGT), can discriminate controls from persons with ventral medial frontal lesions, substance-dependence, and pathological gambling. Positron emissi...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20344

    authors: Tanabe J,Thompson L,Claus E,Dalwani M,Hutchison K,Banich MT

    更新日期:2007-12-01 00:00:00

  • Evaluating and reducing the impact of white matter lesions on brain volume measurements.

    abstract::MR-based measurements of brain volumes may be affected by the presence of white matter (WM) lesions. Here, we assessed how and to what extent this may happen for WM lesions of various sizes and intensities. After inserting WM lesions of different sizes and intensities into T1-W brain images of healthy subjects, we ass...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21344

    authors: Battaglini M,Jenkinson M,De Stefano N

    更新日期:2012-09-01 00:00:00

  • Brain and soccer: Functional patterns of brain activity during the generation of creative moves in real soccer decision-making situations.

    abstract::This fMRI study investigated brain activity while soccer players were imagining creative moves in real soccer decision-making situations. After presenting brief video clips of a soccer scene, participants had to imagine themselves as the acting player and think either of a creative or obvious move that might lead to a...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24408

    authors: Fink A,Bay JU,Koschutnig K,Prettenthaler K,Rominger C,Benedek M,Papousek I,Weiss EM,Seidel A,Memmert D

    更新日期:2019-02-15 00:00:00

  • Characterization of disease-related covariance topographies with SSMPCA toolbox: effects of spatial normalization and PET scanners.

    abstract::To generate imaging biomarkers from disease-specific brain networks, we have implemented a general toolbox to rapidly perform scaled subprofile modeling (SSM) based on principal component analysis (PCA) on brain images of patients and normals. This SSMPCA toolbox can define spatial covariance patterns whose expression...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22295

    authors: Peng S,Ma Y,Spetsieris PG,Mattis P,Feigin A,Dhawan V,Eidelberg D

    更新日期:2014-05-01 00:00:00

  • Are there theory of mind regions in the brain? A review of the neuroimaging literature.

    abstract::There have been many functional imaging studies of the brain basis of theory of mind (ToM) skills, but the findings are heterogeneous and implicate anatomical regions as far apart as orbitofrontal cortex and the inferior parietal lobe. The functional imaging studies are reviewed to determine whether the diverse findin...

    journal_title:Human brain mapping

    pub_type: 杂志文章,评审

    doi:10.1002/hbm.20671

    authors: Carrington SJ,Bailey AJ

    更新日期:2009-08-01 00:00:00

  • Cross auditory-spatial learning in early-blind individuals.

    abstract::Cross-modal processing enables the utilization of information received via different sensory organs to facilitate more complicated human actions. We used functional MRI on early-blind individuals to study the neural processes associated with cross auditory-spatial learning. The auditory signals, converted from echoes ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21395

    authors: Chan CC,Wong AW,Ting KH,Whitfield-Gabrieli S,He J,Lee TM

    更新日期:2012-11-01 00:00:00

  • Greater leftward lateralization of the inferior frontal gyrus in second language learners with higher syntactic abilities.

    abstract::There is a great individual variability for acquiring syntactic knowledge in a second language (L2). Little is, however, known if there is any anatomical basis in the brain for individual differences in syntactic acquisition. Here we examined brain structures in 95 nonnative speakers of English, including 78 high-scho...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20790

    authors: Nauchi A,Sakai KL

    更新日期:2009-11-01 00:00:00

  • Constructing and evaluating a cortical surface atlas and analyzing cortical sex differences in young Chinese adults.

    abstract::Cortical surface templates are an important standardized coordinate frame for cortical structure and function analysis in magnetic resonance (MR) imaging studies. The widely used adult cortical surface templates (e.g., fsaverage, Conte69, and the HCP-MMP atlas) are based on the Caucasian population. Neuroanatomical di...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24960

    authors: Yang G,Bozek J,Han M,Gao JH

    更新日期:2020-06-15 00:00:00

  • Thalamocortical sensorimotor circuit in multiple sclerosis: an integrated structural and electrophysiological assessment.

    abstract::Demyelination and axonal damage are pathologic hallmarks of multiple sclerosis (MS), leading to loss of neuronal synchronization, functional disconnection amongst brain relays, and clinical sequelae. To investigate these properties, the primary component of the sensorimotor network was analyzed in mildly disabled Rela...

    journal_title:Human brain mapping

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/hbm.20961

    authors: Dell'Acqua ML,Landi D,Zito G,Zappasodi F,Lupoi D,Rossini PM,Filippi MM,Tecchio F

    更新日期:2010-10-01 00:00:00

  • Functional magnetic resonance imaging (fMRI) item analysis of empathy and theory of mind.

    abstract::In contrast to conventional functional magnetic resonance imaging (fMRI) analysis across participants, item analysis allows generalizing the observed neural response patterns from a specific stimulus set to the entire population of stimuli. In the present study, we perform an item analysis on an fMRI paradigm (EmpaToM...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24966

    authors: Tholen MG,Trautwein FM,Böckler A,Singer T,Kanske P

    更新日期:2020-07-01 00:00:00

  • Longitudinal development in the preterm thalamus and posterior white matter: MRI correlations between diffusion weighted imaging and T2 relaxometry.

    abstract::Infants born prematurely are at increased risk of adverse neurodevelopmental outcome. The measurement of white matter tissue composition and structure can help predict functional performance. Specifically, measurements of myelination and indicators of myelination status in the preterm brain could be predictive of late...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23188

    authors: Melbourne A,Eaton-Rosen Z,Orasanu E,Price D,Bainbridge A,Cardoso MJ,Kendall GS,Robertson NJ,Marlow N,Ourselin S

    更新日期:2016-07-01 00:00:00

  • Does the insula contribute to emotion-related distortion of time? A neuropsychological approach.

    abstract::The literature points to a large distributed brain network involved in the estimation of time. Among these regions, the role of the insular cortex is still poorly understood. At the confluence of emotional, interoceptive, and environmental signals, this brain structure has been proposed to underlie awareness of the pa...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24460

    authors: Mella N,Bourgeois A,Perren F,Viaccoz A,Kliegel M,Picard F

    更新日期:2019-04-01 00:00:00

  • Attentional modulation of reward processing in the human brain.

    abstract::Although neural signals of reward anticipation have been studied extensively, the functional relationship between reward and attention has remained unclear: Neural signals implicated in reward processing could either reflect attentional biases towards motivationally salient stimuli, or proceed independently of attenti...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22383

    authors: Rothkirch M,Schmack K,Deserno L,Darmohray D,Sterzer P

    更新日期:2014-07-01 00:00:00

  • Preserved executive function in high-performing elderly is driven by large-scale recruitment of prefrontal cortical mechanisms.

    abstract::High-density electrical mapping of event-related potentials was used to investigate the neural processes that permit some elderly subjects to preserve high levels of executive functioning. Two possibilities pertain: (1) high-performance in elderly subjects is underpinned by similar processing mechanisms to those seen ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20839

    authors: De Sanctis P,Gomez-Ramirez M,Sehatpour P,Wylie GR,Foxe JJ

    更新日期:2009-12-01 00:00:00

  • Automated post-hoc noise cancellation tool for audio recordings acquired in an MRI scanner.

    abstract::There are several types of experiment in which it is useful to have subjects speak overtly in a magnetic resonance imaging (MRI) scanner, including those studying the articulatory apparatus and the neural basis of speech production, and fMRI experiments in which speech is used as a response modality. Although it is re...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20085

    authors: Cusack R,Cumming N,Bor D,Norris D,Lyzenga J

    更新日期:2005-04-01 00:00:00

  • Combined neuroimaging and gene expression analysis of the genetic basis of brain plasticity indicates across species homology.

    abstract::Brain plasticity and memory formation depend on the expression of a large number of genes. This relationship had been studied using several experimental approaches and researchers have identified genes regulating plasticity through a variety of mechanisms. Despite this effort, a great deal remains unknown regarding th...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22592

    authors: Dinai Y,Wolf L,Assaf Y

    更新日期:2014-12-01 00:00:00

  • Resting-state functional connectivity of the human hypothalamus.

    abstract::The hypothalamus is of enormous importance for multiple bodily functions such as energy homeostasis. Especially, rodent studies have greatly contributed to our understanding how specific hypothalamic subregions integrate peripheral and central signals into the brain to control food intake. In humans, however, the neur...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22607

    authors: Kullmann S,Heni M,Linder K,Zipfel S,Häring HU,Veit R,Fritsche A,Preissl H

    更新日期:2014-12-01 00:00:00

  • Group analysis and the subject factor in functional magnetic resonance imaging: analysis of fifty right-handed healthy subjects in a semantic language task.

    abstract::Before considering a given fMRI paradigm as a valid clinical tool, one should first assess the reliability of functional responses across subjects by establishing a normative database and defining a reference activation map that identifies major brain regions involved in the task at hand. However, the definition of su...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20410

    authors: Seghier ML,Lazeyras F,Pegna AJ,Annoni JM,Khateb A

    更新日期:2008-04-01 00:00:00

  • The imprint of childhood adversity on emotional processing in high functioning young adults.

    abstract::Adverse childhood experiences (ACEs) have been acknowledged as risk factors for increased mental health complications in adulthood, specifically increasing susceptibility to developing psychopathology upon exposure to trauma. Yet, little is known regarding the impact of mild ACEs on highly functioning population. In t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.25246

    authors: Mirman A,Bick AS,Kalla C,Canetti L,Segman R,Dan R,Ben Yehuda A,Levin N,Bonne O

    更新日期:2021-02-15 00:00:00

  • Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders.

    abstract::The deviation between chronological age and age predicted using brain MRI is a putative marker of overall brain health. Age prediction based on structural MRI data shows high accuracy in common brain disorders. However, brain aging is complex and heterogenous, both in terms of individual differences and the underlying...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.25323

    authors: Rokicki J,Wolfers T,Nordhøy W,Tesli N,Quintana DS,Alnaes D,Richard G,de Lange AG,Lund MJ,Norbom L,Agartz I,Melle I,Naerland T,Selbaek G,Persson K,Nordvik JE,Schwarz E,Andreassen OA,Kaufmann T,Westlye LT

    更新日期:2020-12-19 00:00:00

  • Three-dimensional linear and nonlinear transformations: an integration of light microscopical and MRI data.

    abstract::The registration of image volumes derived from different imaging modalities such as MRI, PET, SPECT, and CT has been described in numerous studies in which functional and morphological data are combined on the basis of macrostructural information. However, the exact topography of architectural details is defined by mi...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:

    authors: Schormann T,Zilles K

    更新日期:1998-01-01 00:00:00

  • Three-dimensional mapping of cortical thickness using Laplace's equation.

    abstract::We present a novel, computerized method of examining cerebral cortical thickness. The normal cortex varies in thickness from 2 to 4 mm, reflecting the morphology of neuronal sublayers. Cortical pathologies often manifest abnormal variations in thickness, with examples of Alzheimer's disease and cortical dysplasia as t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/1097-0193(200009)11:1<12::aid-hbm20>3.0.co

    authors: Jones SE,Buchbinder BR,Aharon I

    更新日期:2000-09-01 00:00:00

  • Functional centrality of amygdala, striatum and hypothalamus in a "small-world" network underlying joy: an fMRI study with music.

    abstract::Current knowledge about small-world networks underlying emotions is sparse, and confined to functional magnetic resonance imaging (fMRI) studies using resting-state paradigms. This fMRI study applied Eigenvector Centrality Mapping (ECM) and functional connectivity analysis to reveal neural small-world networks underly...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22416

    authors: Koelsch S,Skouras S

    更新日期:2014-07-01 00:00:00

  • Predictive modeling of EEG time series for evaluating surgery targets in epilepsy patients.

    abstract::During the last 20 years, predictive modeling in epilepsy research has largely been concerned with the prediction of seizure events, whereas the inference of effective brain targets for resective surgery has received surprisingly little attention. In this exploratory pilot study, we describe a distributional clusterin...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23537

    authors: Steimer A,Müller M,Schindler K

    更新日期:2017-05-01 00:00:00