Abstract:
:To generate imaging biomarkers from disease-specific brain networks, we have implemented a general toolbox to rapidly perform scaled subprofile modeling (SSM) based on principal component analysis (PCA) on brain images of patients and normals. This SSMPCA toolbox can define spatial covariance patterns whose expression in individual subjects can discriminate patients from controls or predict behavioral measures. The technique may depend on differences in spatial normalization algorithms and brain imaging systems. We have evaluated the reproducibility of characteristic metabolic patterns generated by SSMPCA in patients with Parkinson's disease (PD). We used [(18) F]fluorodeoxyglucose PET scans from patients with PD and normal controls. Motor-related (PDRP) and cognition-related (PDCP) metabolic patterns were derived from images spatially normalized using four versions of SPM software (spm99, spm2, spm5, and spm8). Differences between these patterns and subject scores were compared across multiple independent groups of patients and control subjects. These patterns and subject scores were highly reproducible with different normalization programs in terms of disease discrimination and cognitive correlation. Subject scores were also comparable in patients with PD imaged across multiple PET scanners. Our findings confirm a very high degree of consistency among brain networks and their clinical correlates in PD using images normalized in four different SPM platforms. SSMPCA toolbox can be used reliably for generating disease-specific imaging biomarkers despite the continued evolution of image preprocessing software in the neuroimaging community. Network expressions can be quantified in individual patients independent of different physical characteristics of PET cameras.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Peng S,Ma Y,Spetsieris PG,Mattis P,Feigin A,Dhawan V,Eidelberg Ddoi
10.1002/hbm.22295subject
Has Abstractpub_date
2014-05-01 00:00:00pages
1801-14issue
5eissn
1065-9471issn
1097-0193journal_volume
35pub_type
杂志文章abstract::Depressive symptoms often coexist with memory deficits in older adults and also are associated with incident cognitive decline in the elderly. However, little is known about the neural correlates of the association between depressive symptoms and memory deficits in nondemented elderly. Fifteen amnestic mild cognitive ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21291
更新日期:2012-06-01 00:00:00
abstract::Positron emission tomography (PET) was used to investigate the functional anatomy of the foveal fixation system in 10 subjects scanned under three different conditions: at rest (REST), during the fixation of a central point (FIX), and while fixating the same foveal target during the presentation of peripheral visual d...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(sici)1097-0193(1999)8:1<28::aid-hbm3>3.0.
更新日期:1999-01-01 00:00:00
abstract::This paper describes a Bayesian method for three-dimensional registration of brain images. A finite element approach is used to obtain a maximum a posteriori estimate of the deformation field at every voxel of a template volume. The priors used by the MAP estimate penalize unlikely deformations and enforce a continuou...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(sici)1097-0193(200004)9:4<212::aid-hbm3>3
更新日期:2000-04-01 00:00:00
abstract::Active listening has been reported to elicit a different sensory response from passive listening and is generally observed as an increase in the magnitude of activation. Sensory activation differences may therefore be masked by the effect of attention. The present study measured activation induced by static and modula...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract::A diffusion-weighted (DW) template in a standard coordinate system is often necessary for the analysis of white matter (WM) structures using DW images. Although several DW templates have been constructed in the ICBM-152 space, a template for diffusion spectrum imaging (DSI) is still lacking. In this study, we develope...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22860
更新日期:2015-09-01 00:00:00
abstract::The goal of the present study was to investigate the neuroanatomical basis of arithmetic fact retrieval. The rationale was that areas playing a crucial role in arithmetic fact retrieval should show a systematic increase of activation with increasing retrieval effort. To achieve this goal, we utilized the problem-size ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21002
更新日期:2011-01-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease, which primarily targets the motor system. The structural integrity of the motor network and the way it is embedded in the overall brain network is essential for motor functioning. We studied the longitudinal effects of ALS on the brain network ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22258
更新日期:2014-04-01 00:00:00
abstract::Increased cerebral blood flow in the anterior cingulate cortex (ACC) has been noted in a range of cognitively demanding tasks studied with PET. A PET study of 10 normal males was carried out using the bolus H2(15)O intravenous injection technique to examine the effects of anticipation on blood flow to the ACC. In a se...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1996)4:2<103::AID-HBM2>3.0
更新日期:1996-01-01 00:00:00
abstract::Inattentional deafness is the failure to hear otherwise audible sounds (usually alarms) that may occur under high workload conditions. One potential cause for its occurrence could be an attentional bottleneck that occurs when task demands are high, resulting in lack of resources for processing of additional tasks. In ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23735
更新日期:2017-11-01 00:00:00
abstract::Vitamin D deficiency may exacerbate adverse neurocognitive outcomes in the progression of diseases such as Parkinson's, Alzheimer's, and other dementias. Mild cognitive impairment (MCI) is prodromal for these neurocognitive disorders and neuroimaging studies suggest that, in the elderly, this cognitive impairment is a...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24380
更新日期:2019-02-01 00:00:00
abstract::The preprocessing pipelines typically used in both task and resting-state functional magnetic resonance imaging (rs-fMRI) analysis are modular in nature: They are composed of a number of separate filtering/regression steps, including removal of head motion covariates and band-pass filtering, performed sequentially and...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24528
更新日期:2019-06-01 00:00:00
abstract::The motivation to receive rewards enhances episodic memories, and the motivation is modulated by task difficulty. In episodic retrieval, however, functional neuroimaging evidence regarding the motivation that mediates interactions between reward and task difficulty is scarce. The present fMRI study investigated this i...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23599
更新日期:2017-07-01 00:00:00
abstract::A theoretical framework supporting experimental measures of dynamic properties of human EEG is proposed with emphasis on distinct alpha rhythms. Robust relationships between measured dynamics and cognitive or behavioral conditions are reviewed, and proposed physiological bases for EEG at cellular levels are considered...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.1030
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:To determine the functional connectivity of different EEG bands at the "baseline" situation (rest) and during mathematical thinking in children and young adults to study the maturation effect on brain networks at rest and during a cognitive task. METHODS:Twenty children (8-12 years) and twenty students (21-2...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20492
更新日期:2009-01-01 00:00:00
abstract::The mirror neuron system (MNS) is considered crucial for human imitation and language learning and provides the basis for the development of empathy and mentalizing. Alexithymia (ALEX), which refers to deficiencies in the self-awareness of emotional states, has been reported to be associated with poor ability in vario...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20653
更新日期:2009-07-01 00:00:00
abstract::The deviation between chronological age and age predicted using brain MRI is a putative marker of overall brain health. Age prediction based on structural MRI data shows high accuracy in common brain disorders. However, brain aging is complex and heterogenous, both in terms of individual differences and the underlying...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25323
更新日期:2020-12-19 00:00:00
abstract::The acquisition of functional magnetic resonance imaging (fMRI) data in a finite subset of k-space produces ring-artifacts and 'side lobes' that distort the image. In this article, we explore the consequences of this problem for functional imaging studies, which can be considerable, and propose a solution. The truncat...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20475
更新日期:2008-11-01 00:00:00
abstract::Constrained spherical deconvolution (CSD) of diffusion-weighted MRI (DW-MRI) is a popular analysis method that extracts the full white matter (WM) fiber orientation density function (fODF) in the living human brain, noninvasively. It assumes that the DW-MRI signal on the sphere can be represented as the spherical conv...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25241
更新日期:2020-11-10 00:00:00
abstract::This meta-analytic connectivity modeling (MACM) study explores the functional connectivity of the cerebellum with the cerebrum in social cognitive processes. In a recent meta-analysis, Van Overwalle, Baetens, Mariën, and Vandekerckhove (2014) documented that the cerebellum is implicated in social processes of "body" r...
journal_title:Human brain mapping
pub_type: 杂志文章,meta分析,评审
doi:10.1002/hbm.23002
更新日期:2015-12-01 00:00:00
abstract::The presence of white matter lesions in patients with cerebral small vessel disease (SVD) is among the main causes of cognitive decline. We investigated the relation between white matter hyperintensity (WMH) locations and executive and language abilities in 442 SVD patients without dementia with varying burden of WMH....
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25273
更新日期:2020-11-24 00:00:00
abstract::BOLD functional MRI (fMRI) data are dominated by low frequency signals, many of them of unclear origin. We have recently shown that some portions of the low frequency oscillations found in BOLD fMRI are systemic signals closely related to the blood circulation (Tong et al. [2013]: NeuroImage 76:202-215). They are comm...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22564
更新日期:2014-11-01 00:00:00
abstract::Previous structural and functional neuroimaging studies have implicated distributed brain regions and networks in depression. However, there are no robust imaging biomarkers that are specific to depression, which may be due to clinical heterogeneity and neurobiological complexity. A dimensional approach and fusion of ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24802
更新日期:2020-01-01 00:00:00
abstract::Adolescence is a time period associated with marked brain maturation that coincides with an enhanced risk for onset of psychiatric disorder. White matter tract myelination, a process that continues to unfold throughout adolescence, is reported to be abnormal in several psychiatric disorders. Here, we ask whether psych...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24842
更新日期:2020-02-15 00:00:00
abstract::Diffusion tensor imaging (DTI) can be used to index white matter integrity of the corticospinal tract (CST) after stroke; however, the psychometric properties of DTI-based measures of white matter integrity are unknown. The purpose of this study was to examine test-retest reliability as determined by intraclass correl...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24961
更新日期:2020-06-15 00:00:00
abstract::It is unknown to what extent briefly presented emotional words can be processed without awareness. By means of two independent functional magnetic resonance imaging studies, using either a block or an event-related design, we investigated brain activation to very briefly presented threat related and neutral words duri...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22654
更新日期:2015-02-01 00:00:00
abstract::To capture patterns of normal age-associated atrophy, we previously used a multivariate statistical approach applied to voxel based morphometry that identified age-associated gray and white matter covariance networks (Brickman et al. [2007]: Neurobiol Aging 28:284-295). The current study sought to examine the stabilit...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20452
更新日期:2008-10-01 00:00:00
abstract::The overall goal of this work is to demonstrate how resting state functional magnetic resonance imaging (fMRI) signals may be used to objectively parcellate functionally heterogeneous subregions of the human amygdala into structures characterized by similar patterns of functional connectivity. We hypothesize that simi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22249
更新日期:2014-04-01 00:00:00
abstract::We present a method for registering a brain in the Talairach coordinate system that can be performed either "online," i.e., in real time while a subject is in a magnetic resonance scanner, or "offline" on a previously acquired three-dimensional (3D) data set. The method is applicable to functional magnetic resonance i...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1997)5:1<58::AID-HBM6>3.0.
更新日期:1997-01-01 00:00:00
abstract::What is the neural substrate of our capability to properly react to changes in the environment? It can be hypothesized that the anterior cingulate cortex (ACC) manages repetitive stimuli in routine conditions and alerts the dorsolateral prefrontal cortex (PFC) when stimulation unexpectedly changes. To provide evidence...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20491
更新日期:2009-01-01 00:00:00
abstract::The posteromedial cortex (PMC) is a key region involved in the development and progression of Alzheimer's disease (AD). Previous studies have demonstrated a heterogenous functional architecture of the region that is composed of discrete functional modules reflecting a complex pattern of functional connectivity. Howeve...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24894
更新日期:2020-04-15 00:00:00