Abstract:
:The mirror neuron system (MNS) is considered crucial for human imitation and language learning and provides the basis for the development of empathy and mentalizing. Alexithymia (ALEX), which refers to deficiencies in the self-awareness of emotional states, has been reported to be associated with poor ability in various aspects of social cognition such as mentalizing, cognitive empathy, and perspective-taking. Using functional magnetic resonance imaging (fMRI), we measured the hemodynamic signal to examine whether there are functional differences in the MNS activity between participants with ALEX (n = 16) and without ALEX (n = 13), in response to a classic MNS task (i.e., the observation of video clips depicting goal-directed hand movements). Both groups showed increased neural activity in the premotor and the parietal cortices during observation of hand actions. However, activation was greater for the ALEX group than the non-ALEX group. Furthermore, activation in the left premotor area was negatively correlated with perspective-taking ability as assessed with the interpersonal reactivity index. The signal in parietal cortices was negatively correlated with cognitive facets assessed by the stress coping inventory and positively correlated with the neuroticism scale from the NEO five factor personality scale. In addition, in the ALEX group, activation in the right superior parietal region showed a positive correlation with the severity of ALEX as measured by a structured interview. These results suggest that the stronger MNS-related neural response in individuals scoring high on ALEX is associated with their insufficient self-other differentiation.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Moriguchi Y,Ohnishi T,Decety J,Hirakata M,Maeda M,Matsuda H,Komaki Gdoi
10.1002/hbm.20653subject
Has Abstractpub_date
2009-07-01 00:00:00pages
2063-76issue
7eissn
1065-9471issn
1097-0193journal_volume
30pub_type
杂志文章abstract::We describe a functional neuroanatomy approach that combines structural (MRI) and functional (PET) data at the individual level. For each subject MRI dataset, sulci are first localized using hemisphere surface rendering and sections and stored. Using these landmarks, the subject brain volume is then divided in 100 ana...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1997)5:4<228::AID-HBM4>3.0
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:To investigate the function-structure relationship of white matter within different stages of Huntington's disease (HD) using diffusion tensor imaging (DTI). EXPERIMENTAL DESIGN:From the TRACK-HD study, an early stage HD group and a premanifest gene carrier group (PMGC) were age-matched to two healthy contr...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21205
更新日期:2012-01-01 00:00:00
abstract::The spatial organization of nonlinear interactions between different brain regions during the first NREM sleep stage is investigated. This is achieved via consideration of four bipolar electrode derivations, Fp1F3, Fp2F4, O1P3, O2P4, which are used to compare anterior and posterior interhemispheric interactions and le...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20052
更新日期:2004-10-01 00:00:00
abstract::Cross-modal processing enables the utilization of information received via different sensory organs to facilitate more complicated human actions. We used functional MRI on early-blind individuals to study the neural processes associated with cross auditory-spatial learning. The auditory signals, converted from echoes ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21395
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To assess the structural correlates of cognitive and behavioral impairment in motor neuron diseases (MND) using multimodal MRI. METHODS:One hundred one patients with sporadic MND (56 classic amyotrophic lateral sclerosis, 31 upper motor neuron phenotype, and 14 lower motor neuron phenotype) and 51 controls w...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23124
更新日期:2016-04-01 00:00:00
abstract::It has been suggested that in humans the mirror neuron system provides a neural substrate for imitation behaviour, but the relative contributions of different brain regions to the imitation of manual actions is still a matter of debate. To investigate the role of the mirror neuron system in imitation we used fMRI to e...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20938
更新日期:2010-09-01 00:00:00
abstract::The default-mode network (DMN) is a set of specific brain regions whose activity, predominant in the resting-state, is attenuated during cognitively demanding, externally-cued tasks. The cognitive correlates of this network have proven difficult to interrogate, but one hypothesis is that regions in the network process...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20537
更新日期:2008-07-01 00:00:00
abstract::Standard procedures to achieve quality assessment (QA) of functional magnetic resonance imaging (fMRI) data are of great importance. A standardized and fully automated procedure for QA is presented that allows for classification of data quality and the detection of artifacts by inspecting temporal variations. The appl...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20096
更新日期:2005-06-01 00:00:00
abstract::The orbitofrontal cortex (OFC)-amygdala circuit is critical to goal-directed behavior, learning, and valuation. However, our understanding of the OFC-amygdala connections that support these emergent processes is hampered by our reliance on the primate literature and insufficient knowledge regarding the connectivity pa...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25300
更新日期:2020-12-03 00:00:00
abstract::We investigated brain responses to matching versus nonmatching objects in working memory (WM) with a modified delayed match-to-sample task using event-related potentials (ERPs). In addition, ERP correlates of new items (new matches/new nonmatches) and previously studied items (studied matches/studied nonmatches) were ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20409
更新日期:2008-04-01 00:00:00
abstract::Cortical surface templates are an important standardized coordinate frame for cortical structure and function analysis in magnetic resonance (MR) imaging studies. The widely used adult cortical surface templates (e.g., fsaverage, Conte69, and the HCP-MMP atlas) are based on the Caucasian population. Neuroanatomical di...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24960
更新日期:2020-06-15 00:00:00
abstract::Rapid emotion processing is an ecologically essential ability for survival in social environments in which threatening or advantageous encounters dynamically and rapidly occur. Efficient emotion recognition is subserved by different processes, depending on one's expectations; however, the underlying functional and str...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24779
更新日期:2019-12-15 00:00:00
abstract::Patients with advanced Parkinson's disease (PD) develop disabling axial symptoms, including gait disturbances, freezing and postural instability poorly responsive to levodopa replacement therapy. The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20815
更新日期:2009-12-01 00:00:00
abstract::Positron emission tomography (PET) was used to investigate the functional anatomy of the foveal fixation system in 10 subjects scanned under three different conditions: at rest (REST), during the fixation of a central point (FIX), and while fixating the same foveal target during the presentation of peripheral visual d...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(sici)1097-0193(1999)8:1<28::aid-hbm3>3.0.
更新日期:1999-01-01 00:00:00
abstract::Major depressive disorder (MDD) is highly prevalent and associated with considerable morbidity, yet its pathophysiology remains only partially understood. While numerous studies have investigated the neurobiological correlates of MDD, most have used only a single neuroimaging modality. In particular, diffusion tensor ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24679
更新日期:2019-09-01 00:00:00
abstract::Cognitive deficits are common in Parkinson's disease and we suspect that dysfunctions of connected brain regions can be the source of these deficits. The aim of the present study was to investigate changes in whole-brain intrinsic functional connectivity according to differences in cognitive profiles in Parkinson's di...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23474
更新日期:2017-03-01 00:00:00
abstract::Transcranial direct current stimulation (tDCS) induces polarity- and dose-dependent neuroplastic aftereffects on cortical excitability and cortical activity, as demonstrated by transcranial magnetic stimulation (TMS) and functional imaging (fMRI) studies. However, lacking systematic comparative studies between stimula...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24901
更新日期:2020-04-15 00:00:00
abstract::Word production is a complex multistage process linking conceptual representations, lexical entries, phonological forms and articulation. Previous studies have revealed a network of predominantly left-lateralized brain regions supporting this process, but many details regarding the precise functions of different nodes...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20782
更新日期:2009-11-01 00:00:00
abstract::A face-selective neural signal is reliably found in humans with functional MRI and event-related potential (ERP) measures, which provide complementary information about the spatial and temporal properties of the neural response. However, because most neuroimaging studies so far have studied ERP and fMRI face-selective...
journal_title:Human brain mapping
pub_type: 杂志文章,随机对照试验
doi:10.1002/hbm.20952
更新日期:2010-10-01 00:00:00
abstract::The presence of white matter lesions in patients with cerebral small vessel disease (SVD) is among the main causes of cognitive decline. We investigated the relation between white matter hyperintensity (WMH) locations and executive and language abilities in 442 SVD patients without dementia with varying burden of WMH....
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25273
更新日期:2020-11-24 00:00:00
abstract::Many studies have suggested that childhood maltreatment increase risk of adulthood major depressive disorder (MDD) and predict its unfavorable treatment outcome, yet the neural underpinnings associated with childhood maltreatment in MDD remain poorly understood. Here, we seek to investigate the whole-brain functional ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22241
更新日期:2014-04-01 00:00:00
abstract::One of the major findings from multimodal neuroimaging studies in the past decade is that the human brain is anatomically and functionally organized into large-scale networks. In resting state fMRI (rs-fMRI), spatial patterns emerge when temporal correlations between various brain regions are tallied, evidencing netwo...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22865
更新日期:2015-09-01 00:00:00
abstract::The TREK1 gene has been linked to a depression-resistant phenotype in rodents and antidepressant response in humans, but the neural mechanisms underlying these links are unclear. Because TREK1 is expressed in reward-related basal ganglia regions, it has been hypothesized that TREK1 genetic variation may be associated ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20858
更新日期:2010-02-01 00:00:00
abstract::Degeneration of the corpus callosum (CC) is evident in the pathogenesis of Alzheimer's disease (AD). However, the correlation of microstructural damage in the CC on the cognitive performance of patients with amnestic mild cognitive impairment (aMCI) and AD dementia is undetermined. We enrolled 26 normal controls, 24 p...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22271
更新日期:2014-04-01 00:00:00
abstract::Simultaneous electroencephalography and functional magnetic resonance imaging (EEG/fMRI) have been proposed to contribute to the definition of the epileptic seizure onset zone. Following interictal epileptiform discharges, one usually assumes a canonical hemodynamic response function (HRF), which has been derived from...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20925
更新日期:2010-08-01 00:00:00
abstract::Behavioral evidence and theory suggest gesture and language processing may be part of a shared cognitive system for communication. While much research demonstrates both gesture and language recruit regions along perisylvian cortex, relatively less work has tested functional segregation within these regions on an indiv...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23251
更新日期:2016-10-01 00:00:00
abstract::Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by progressive decline in memory and other aspects of cognitive function. Diffusion-weighted imaging (DWI) offers a non-invasive approach to delineate the effects of AD on white matter (WM) integrity. Previous studies calculated either some ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23448
更新日期:2017-03-01 00:00:00
abstract::Magnetoencephalographic (MEG) investigations of inter-regional amplitude correlations have yielded new insights into the organization and neurophysiology of resting-state networks (RSNs) first identified using fMRI. Inter-regional MEG amplitude correlations in adult RSNs have been shown to be most prominent in alpha a...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22547
更新日期:2014-10-01 00:00:00
abstract::Mental calculation is a complex mental procedure involving a frontoparietal network of brain regions. Functional MRI (fMRI) studies have revealed interesting characteristics of these regions, but the precise function of some areas remains elusive. In the present study, we used electrocorticographic (ECoG) recordings t...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22593
更新日期:2014-12-01 00:00:00
abstract::The origin of within-subject variability in perceptual experiments is poorly understood. We here review evidence that baseline brain activity in the areas involved in sensory perception predict subsequent variations in sensory awareness. We place these findings in light of recent findings on the architecture of sponta...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.20602
更新日期:2008-07-01 00:00:00