Abstract:
:We investigated brain responses to matching versus nonmatching objects in working memory (WM) with a modified delayed match-to-sample task using event-related potentials (ERPs). In addition, ERP correlates of new items (new matches/new nonmatches) and previously studied items (studied matches/studied nonmatches) were examined in the WM task. Half of the common visual objects were initially studied until 95% accuracy was attained and half were new. Each memory trial began with the presentation of a sample object followed by nine test objects. Participants indicated whether each test item was the same as the object held in mind (i.e., match) or a nonmatch. Compared to studied matches, new matches evoked activity that was 50 ms earlier and largest at frontal sites. In contrast, P3 activity associated with studied nonmatches was larger than for new nonmatches at mostly posterior sites, which parallels previously reported old-new ERP effects. The ERP source analysis further confirms that the cortical mechanisms underlying matching objects and rejecting irrelevant objects during the task are both temporally and spatially distinct. Moreover, our current findings suggest that prior learning affects brain responses to matching visual items during a WM task.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Guo C,Lawson AL,Zhang Q,Jiang Ydoi
10.1002/hbm.20409subject
Has Abstractpub_date
2008-04-01 00:00:00pages
441-52issue
4eissn
1065-9471issn
1097-0193journal_volume
29pub_type
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