Abstract:
:Functional connectivity analysis of brain networks has become an important tool for investigation of human brain function. Although functional connectivity computations are usually based on resting-state data, the application to task-specific fMRI has received growing attention. Three major methods for extraction of resting-state data from task-related signal have been proposed (1) usage of unmanipulated task data for functional connectivity; (2) regression against task effects, subsequently using the residuals; and (3) concatenation of baseline blocks located in-between task blocks. Despite widespread application in current research, consensus on which method best resembles resting-state seems to be missing. We, therefore, evaluated these techniques in a sample of 26 healthy controls measured at 7 Tesla. In addition to continuous resting-state, two different task paradigms were assessed (emotion discrimination and right finger-tapping) and five well-described networks were analyzed (default mode, thalamus, cuneus, sensorimotor, and auditory). Investigating the similarity to continuous resting-state (Dice, Intraclass correlation coefficient (ICC), R(2) ) showed that regression against task effects yields functional connectivity networks most alike to resting-state. However, all methods exhibited significant differences when compared to continuous resting-state and similarity metrics were lower than test-retest of two resting-state scans. Omitting global signal regression did not change these findings. Visually, the networks are highly similar, but through further investigation marked differences can be found. Therefore, our data does not support referring to resting-state when extracting signals from task designs, although functional connectivity computed from task-specific data may indeed yield interesting information.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Ganger S,Hahn A,Küblböck M,Kranz GS,Spies M,Vanicek T,Seiger R,Sladky R,Windischberger C,Kasper S,Lanzenberger Rdoi
10.1002/hbm.22897subject
Has Abstractpub_date
2015-10-01 00:00:00pages
4053-63issue
10eissn
1065-9471issn
1097-0193journal_volume
36pub_type
杂志文章abstract::We studied the relationship between muscle activity (electromyography, EMG), force, and brain activity during isometric contractions of the index finger, on a group and individual level. Ten subjects contracted their right or left index finger at 5, 15, 30, 50, and 70% of their maximal force. Subjects received visual ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20388
更新日期:2008-03-01 00:00:00
abstract::Behavioral evidence and theory suggest gesture and language processing may be part of a shared cognitive system for communication. While much research demonstrates both gesture and language recruit regions along perisylvian cortex, relatively less work has tested functional segregation within these regions on an indiv...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23251
更新日期:2016-10-01 00:00:00
abstract::The amygdala, a small deep brain structure involved in behavioral processing through interactions with other brain regions, has garnered increased attention in recent years in relation to pain processing. As pain is a multidimensional experience that encompasses physical sensation, affect, and cognition, the amygdala ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22199
更新日期:2014-02-01 00:00:00
abstract::Collecting comprehensive data sets of the same subject has become a standard in neuroscience research and uncovering multivariate relationships among collected data sets have gained significant attentions in recent years. Canonical correlation analysis (CCA) is one of the powerful multivariate tools to jointly investi...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.25090
更新日期:2020-09-01 00:00:00
abstract::The anticipation of pain has been investigated in a variety of brain imaging studies. Importantly, today there is no clear overall picture of the areas that are involved in different studies and the exact role of these regions in pain expectation remains especially unexploited. To address this issue, we used activatio...
journal_title:Human brain mapping
pub_type: 杂志文章,meta分析
doi:10.1002/hbm.22727
更新日期:2015-05-01 00:00:00
abstract:PURPOSE:To investigate the intrinsic brain connections at the time of interictal generalized spike-wave discharges (GSWDs) to understand their mechanism of effect on brain function in untreated childhood absence epilepsy (CAE). METHODS:The EEG-functional MRI (fMRI) was used to measure the resting state functional conn...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22025
更新日期:2013-08-01 00:00:00
abstract::Catechol-O-methyltransferase (COMT), located on chromosome 22q11.2, encodes an enzyme critical for dopamine flux in the prefrontal cortex. Genetic variants of COMT have been suggested to functionally manipulate prefrontal morphology and function in healthy adults. This study aims to investigate modulative roles of ind...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23161
更新日期:2016-06-01 00:00:00
abstract::This study aimed to examine early specialization of brain regions for phonological and semantic processing of spoken language in young children. Thirty-five typically developing children aged from 5 to 6 years performed auditory phonological (same sound judgment) and semantic (related meaning judgment) word-level task...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24274
更新日期:2018-11-01 00:00:00
abstract::The human brain can be subdivided many ways depending upon the criteria used. One of the most basic approaches is to subdivide the cortical regions into functional units composed of the frontal, occipital, parietal, and temporal lobes. To date, the process of reliably extracting measurements of the human brain from MR...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1997)5:5<355::AID-HBM4>3.0
更新日期:1997-01-01 00:00:00
abstract::Simultaneous electroencephalography and functional magnetic resonance imaging (EEG/fMRI) have been proposed to contribute to the definition of the epileptic seizure onset zone. Following interictal epileptiform discharges, one usually assumes a canonical hemodynamic response function (HRF), which has been derived from...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20925
更新日期:2010-08-01 00:00:00
abstract::Though fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders are among the most common developmental disorders, their understanding is incomplete. Diffusion tensor imaging (DTI), which is sensitive to microstructural organization in white matter, may provide a relevant measure in this population demonstrat...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20747
更新日期:2009-10-01 00:00:00
abstract::Patients with schizophrenia have patterns of brain deficits including reduced cortical thickness, subcortical gray matter volumes, and cerebral white matter integrity. We proposed the regional vulnerability index (RVI) to translate the results of Enhancing Neuro Imaging Genetics Meta-Analysis studies to the individual...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25045
更新日期:2020-05-28 00:00:00
abstract::There is a great individual variability for acquiring syntactic knowledge in a second language (L2). Little is, however, known if there is any anatomical basis in the brain for individual differences in syntactic acquisition. Here we examined brain structures in 95 nonnative speakers of English, including 78 high-scho...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20790
更新日期:2009-11-01 00:00:00
abstract::Extensive efforts are devoted to understand the functional (FC) and structural connections (SC) of the brain. FC is usually measured by functional magnetic resonance imaging (fMRI), and conceptualized as degree of synchronicity in brain activity between different regions. SC is typically indexed by measures of white m...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23403
更新日期:2017-01-01 00:00:00
abstract::Ventromedial regions of the frontal lobe (vmFL) are thought to play a key role in decision-making and emotional regulation. However, aspects of this area's functional organization, including the presence of a multiple subregions, their functional and anatomical connectivity, and the cross-species homologies of these s...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25014
更新日期:2020-08-15 00:00:00
abstract::It has been suggested that in humans the mirror neuron system provides a neural substrate for imitation behaviour, but the relative contributions of different brain regions to the imitation of manual actions is still a matter of debate. To investigate the role of the mirror neuron system in imitation we used fMRI to e...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20938
更新日期:2010-09-01 00:00:00
abstract::Deficits in information processing speed (IPS) are among the earliest and most prominent cognitive manifestations in mild traumatic brain injury (mTBI). We investigated the impact of white matter fiber location on IPS outcome in an individual basis assessment. A total of 112 acute mild TBI with all CT negative underwe...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25135
更新日期:2020-07-13 00:00:00
abstract::The registration of image volumes derived from different imaging modalities such as MRI, PET, SPECT, and CT has been described in numerous studies in which functional and morphological data are combined on the basis of macrostructural information. However, the exact topography of architectural details is defined by mi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::The neural systems sustaining object naming were examined using the activation likelihood estimation (ALE) meta-analysis approach on the results of 16 previously published studies. The activation task in each study required subjects to name pictures of objects or animals, but the baseline tasks varied. Separate meta-a...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20132
更新日期:2005-05-01 00:00:00
abstract::There have been many functional imaging studies of the brain basis of theory of mind (ToM) skills, but the findings are heterogeneous and implicate anatomical regions as far apart as orbitofrontal cortex and the inferior parietal lobe. The functional imaging studies are reviewed to determine whether the diverse findin...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.20671
更新日期:2009-08-01 00:00:00
abstract::Fractal dimension (FD) has been widely used to provide a quantitative description of structural complexity in the cerebral cortex. FD is an extremely compact measure of shape complexity, condensing all details into a single numeric value. We interpreted the variation of the FD in the cortical surface of normal control...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20238
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:While acceleration in age-related cerebral atrophy has been well documented in Alzheimer's disease, the cerebellar contributions to this effect have not been thoroughly investigated. OBJECTIVE:This study investigated cerebellar volume and atrophy rate using magnetic resonance imaging in individuals with nor...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23580
更新日期:2017-06-01 00:00:00
abstract::Months, days of the week, and numbers differ from other verbal concepts because they are ordered in a sequence, whereas no order is imposed on members of other categories, such as animals or tools. Recent studies suggest that numbers activate a representation of their quantity within the intraparietal sulcus (IPS) aut...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20433
更新日期:2008-08-01 00:00:00
abstract::Magnetic resonance imaging (MRI) studies of fetal alcohol spectrum disorder (FASD) have shown reductions of brain volume associated with prenatal exposure to alcohol. Previous studies consider regional brain volumes independently but ignore potential relationships across numerous structures. This study aims to (a) ide...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24867
更新日期:2020-04-01 00:00:00
abstract::Huntington's disease (HD) is a neurodegenerative disorder which is primarily associated with striatal degeneration. However, the alterations in connectivity of this structure in HD have been underinvestigated. In this study, we analyzed the functional and structural connectivity of the left putamen, while participants...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23813
更新日期:2018-01-01 00:00:00
abstract::Fast cancellation or switching of action plans is a critical cognitive function. Rapid signal transmission is key for quickly executing and inhibiting responses, and the structural integrity of connections between brain regions plays a crucial role in signal transmission speed. In this study, we used the search-step t...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23209
更新日期:2016-08-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) were used to map brain activation during language tasks. While previous studies have compared performance between alphabetic literate and illiterate subjects, there have been no such data in Chinese-speaking individuals. In this study,...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20173
更新日期:2006-02-01 00:00:00
abstract::In functional MRI studies, repetition suppression refers to the reduction of hemodynamic activation to repeated stimulus presentation. For example, the repeated presentation of a face reduces the hemodynamic response evoked by faces in the fusiform gyrus. The neural events that underlie repetition suppression are not ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22467
更新日期:2014-08-01 00:00:00
abstract::Baseline activity of resting state brain networks (RSN) in a resting subject has become one of the fastest growing research topics in neuroimaging. It has been shown that up to 12 RSNs can be differentiated using an independent component analysis (ICA) of the blood oxygen level dependent (BOLD) resting state data. In ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20813
更新日期:2009-12-01 00:00:00
abstract::Listening to music can induce us to tune in to its beat. Previous neuroimaging studies have shown that the motor system becomes involved in perceptual rhythm and timing tasks in general, as well as during preference-related responses to music. However, the role of preferred rhythm and, in particular, of preferred beat...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20844
更新日期:2010-01-01 00:00:00