Oscillations, networks, and their development: MEG connectivity changes with age.

Abstract:

:Magnetoencephalographic (MEG) investigations of inter-regional amplitude correlations have yielded new insights into the organization and neurophysiology of resting-state networks (RSNs) first identified using fMRI. Inter-regional MEG amplitude correlations in adult RSNs have been shown to be most prominent in alpha and beta frequency ranges and to express strong congruence with RSN topologies found using fMRI. Despite such advances, little is known about how oscillatory connectivity in RSNs develops throughout childhood and adolescence. This study used a novel fMRI-guided MEG approach to investigate the maturation of resting-state amplitude correlations in physiologically relevant frequency ranges within and among six RSNs in 59 participants, aged 6-34 years. We report age-related increases in inter-regional amplitude correlations that were largest in alpha and beta frequency bands. In contrast to fMRI reports, these changes were observed both within and between the various RSNs analyzed. Our results provide the first evidence of developmental changes in spontaneous neurophysiological connectivity in source-resolved RSNs, which indicate increasing integration within and among intrinsic functional brain networks throughout childhood, adolescence, and early adulthood.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Schäfer CB,Morgan BR,Ye AX,Taylor MJ,Doesburg SM

doi

10.1002/hbm.22547

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

5249-61

issue

10

eissn

1065-9471

issn

1097-0193

journal_volume

35

pub_type

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