White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood.

Abstract:

:Adolescence is a time period associated with marked brain maturation that coincides with an enhanced risk for onset of psychiatric disorder. White matter tract myelination, a process that continues to unfold throughout adolescence, is reported to be abnormal in several psychiatric disorders. Here, we ask whether psychiatric vulnerability is linked to aberrant developmental myelination trajectories. We assessed a marker of myelin maturation, using magnetisation transfer (MT) imaging, in 10 major white matter tracts. We then investigated its relationship to the expression of a general psychopathology "p-factor" in a longitudinal analysis of 293 healthy participants between the ages of 14 and 24. We observed significant longitudinal MT increase across the full age spectrum in anterior thalamic radiation, hippocampal cingulum, dorsal cingulum and superior longitudinal fasciculus. MT increase in the inferior fronto-occipital fasciculus, inferior longitudinal fasciculus and uncinate fasciculus was pronounced in younger participants but levelled off during the transition into young adulthood. Crucially, longitudinal MT increase in dorsal cingulum and uncinate fasciculus decelerated as a function of mean p-factor scores over the study period. This suggests that an increased expression of psychopathology is closely linked to lower rates of myelin maturation in selective brain tracts over time. Impaired myelin growth in limbic association fibres may serve as a neural marker for emerging mental illness during the course of adolescence and early adulthood.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Vanes LD,Moutoussis M,Ziegler G,Goodyer IM,Fonagy P,Jones PB,Bullmore ET,NSPN Consortium.,Dolan RJ

doi

10.1002/hbm.24842

subject

Has Abstract

pub_date

2020-02-15 00:00:00

pages

827-839

issue

3

eissn

1065-9471

issn

1097-0193

journal_volume

41

pub_type

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