Abstract：
:The preprocessing pipelines typically used in both task and resting-state functional magnetic resonance imaging (rs-fMRI) analysis are modular in nature: They are composed of a number of separate filtering/regression steps, including removal of head motion covariates and band-pass filtering, performed sequentially and in a flexible order. In this article, we illustrate the shortcomings of this approach, as we show how later preprocessing steps can reintroduce artifacts previously removed from the data in prior preprocessing steps. We show that each regression step is a geometric projection of data onto a subspace, and that performing a sequence of projections can move the data into subspaces no longer orthogonal to those previously removed, reintroducing signal related to nuisance covariates. Thus, linear filtering operations are not commutative, and the order in which the preprocessing steps are performed is critical. These issues can arise in practice when any combination of standard preprocessing steps including motion regression, scrubbing, component-based correction, physiological correction, global signal regression, and temporal filtering are performed sequentially. In this work, we focus primarily on rs-fMRI. We illustrate the problem both theoretically and empirically through application to a test-retest rs-fMRI data set, and suggest remedies. These include (a) combining all steps into a single linear filter, or (b) sequential orthogonalization of covariates/linear filters performed in series.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Lindquist MA,Geuter S,Wager TD,Caffo BSdoi
10.1002/hbm.24528subject
Has Abstractpub_date
2019-06-01 00:00:00pages
2358-2376issue
8eissn
1065-9471issn
1097-0193journal_volume
40pub_type
杂志文章abstract：:No study has investigated red nucleus (RN) atrophy in multiple sclerosis (MS) despite cerebellum and its connections are elective sites of MS-related pathology. In this study, we explore RN atrophy in early MS phases and its association with cerebellar damage (focal lesions and atrophy) and physical disability. Thirty...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.25213
更新日期：2021-01-01 00:00:00
abstract：:There has been a recent call for longitudinal imaging studies to better characterize the time course of physiological recovery following sport-related concussion (SRC) and its relationship with clinical recovery. To address this, we evaluated changes to resting-state functional connectivity (rs-FC) of the whole-brain ...
journal_title：Human brain mapping
pub_type： 杂志文章
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abstract：:Human behavior reflects a continual negotiation of automatic and directed actions. The oculomotor network is a well-characterized neural system in which to study this balance of behavioral control. For instance, saccades made toward and away from a flashed visual stimulus (prosaccades and antisaccades, respectively) a...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.20146
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abstract：:Mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) are common among recent military veterans and involve substantial symptom overlap, making clinical distinction and effective intervention difficult. Emerging evidence of cerebral white matter abnormalities associated with mTBI may provide a b...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.22685
更新日期：2015-03-01 00:00:00
abstract：:Everyday communication is accompanied by visual information from several sources, including co-speech gestures, which provide semantic information listeners use to help disambiguate the speaker's message. Using fMRI, we examined how gestures influence neural activity in brain regions associated with processing semanti...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.20774
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abstract：:Reproducibility is one of the most important issues for generalizing the results of clinical research; however, low reproducibility in neuroimaging studies is well known. To overcome this problem, the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium, an international neuroimaging consortium, e...
journal_title：Human brain mapping
pub_type： 杂志文章,评审
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更新日期：2020-06-05 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
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journal_title：Human brain mapping
pub_type： 杂志文章,meta分析
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.20587
更新日期：2009-04-01 00:00:00
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journal_title：Human brain mapping
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doi：10.1002/hbm.24883
更新日期：2020-04-15 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.20653
更新日期：2009-07-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.23251
更新日期：2016-10-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.24274
更新日期：2018-11-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.20782
更新日期：2009-11-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.22242
更新日期：2014-04-01 00:00:00
abstract：:Parkinson's disease (PD) is a neurodegenerative disorder with dysfunction in cortices as well as white matter (WM) tracts. While the changes to WM structure have been extensively investigated in PD, the nature of the functional changes to WM remains unknown. In this study, the regional activity and functional connecti...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.24444
更新日期：2019-03-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.23209
更新日期：2016-08-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.22558
更新日期：2014-11-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.24075
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Trait impulsiveness is a potential factor that predicts both substance use and certain psychiatric disorders. This study investigates whether there are common structural cerebral correlates of trait impulsiveness and cognitive functioning in a large sample of healthy adolescents from the IMAGEN project. MET...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.21446
更新日期：2013-02-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.22112
更新日期：2013-11-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.22293
更新日期：2014-05-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.22383
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journal_title：Human brain mapping
pub_type： 杂志文章,meta分析
doi：10.1002/hbm.24747
更新日期：2019-12-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.20949
更新日期：2011-05-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.21384
更新日期：2012-11-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.23717
更新日期：2017-10-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.22258
更新日期：2014-04-01 00:00:00
abstract：:The nuclei of the human amygdala remain difficult to distinguish in individual subject structural magnetic resonance images. However, interpretation of the amygdala's role in whole brain networks requires accurate localization of functional activity to a particular nucleus or subgroup of nuclei. To address this, high ...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.23289
更新日期：2016-11-01 00:00:00
abstract：:This study constructs a rat brain T2 -weighted magnetic resonance imaging template including olfactory bulb and a compatible digital atlas. The atlas contains 624 carefully delineated brain structures based on the newest (2005) edition of rat brain atlas by Paxinos and Watson. An automated procedure, as an SPM toolbox...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.21511
更新日期：2013-06-01 00:00:00
