Abstract：
:An important function of the brain's orienting response is to enable the evaluation of novel, environmental events in order to prepare for potential behavioral action. Here, we assessed the event-related hemodynamic (erfMRI) correlates of this phenomenon using unexpected (i.e., novel) environmental sounds presented within the context of an auditory novelty oddball paradigm. In ERP investigations of the novelty oddball, repetition of the identical novel sound leads to habituation of the novelty P3, an ERP sign of the orienting response. Repetition also leads to an enhancement of a subsequent positivity that appears to reflect semantic analysis of the environmental sounds. In this adaptation for erfMRI recording, frequent tones were intermixed randomly with infrequent target tones and equally infrequent novel, environmental sounds. Subjects responded via speeded button press to targets. To assess habituation, some of the environmental sounds were repeated two blocks after their initial presentation. As expected, novel sounds and target tones led to activation of widespread, but somewhat different, neural networks. Contrary to expectation, however, there were no significant areas in which activation was reduced in response to second compared to first presentations of the novel sounds. Conversely, novel sounds relative to target tones engendered activity in the inferior frontal gyrus (BA 45) consistent with semantic analysis of these events. We conclude that a key concomitant of the orienting response is the extraction of meaning, thereby enabling one to determine the significance of the environmental perturbation and take appropriate goal-directed action.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Friedman D,Goldman R,Stern Y,Brown TRdoi
10.1002/hbm.20587subject
Has Abstractpub_date
2009-04-01 00:00:00pages
1144-54issue
4eissn
1065-9471issn
1097-0193journal_volume
30pub_type
杂志文章abstract：:Both increases and decreases in resting state functional connectivity have been previously observed within the motor network during aging. Moreover, the relationship between altered functional connectivity and age-related declines in bimanual coordination remains unclear. Here, we explored the developmental dynamics o...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.22450
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:The serotonin transporter (5-HTT) and the 5-HTTLPR/rs25531 polymorphisms in its gene (SLC6A4) have been associated with depression, increased stress-response, and brain structural alterations such as reduced hippocampal volumes. Recently, epigenetic processes including SLC6A4 promoter methylation were shown ...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.22555
更新日期：2014-11-01 00:00:00
abstract：:Degeneration of the corpus callosum (CC) is evident in the pathogenesis of Alzheimer's disease (AD). However, the correlation of microstructural damage in the CC on the cognitive performance of patients with amnestic mild cognitive impairment (aMCI) and AD dementia is undetermined. We enrolled 26 normal controls, 24 p...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.22271
更新日期：2014-04-01 00:00:00
abstract：:There have been many functional imaging studies of the brain basis of theory of mind (ToM) skills, but the findings are heterogeneous and implicate anatomical regions as far apart as orbitofrontal cortex and the inferior parietal lobe. The functional imaging studies are reviewed to determine whether the diverse findin...
journal_title：Human brain mapping
pub_type： 杂志文章,评审
doi：10.1002/hbm.20671
更新日期：2009-08-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.20747
更新日期：2009-10-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.25335
更新日期：2021-01-09 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章,评审
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更新日期：2018-12-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.23608
更新日期：2017-07-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.24980
更新日期：2020-07-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.24883
更新日期：2020-04-15 00:00:00
abstract：:Fine surface texture is best discriminated by touch, in contrast to macro geometric features like shape. We used functional magnetic resonance imaging and a delayed match-to-sample task to investigate the neural substrate for working memory of tactile surface texture. Blindfolded right-handed males encoded the texture...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.21500
更新日期：2013-05-01 00:00:00
abstract：:We propose a hardware and software architecture to respond to crucial problems in the neuroimaging field: storage, retrieval, and processing of large datasets. The B-SPID project, here discussed, concerns the processing of neuroimages and attached components stored in an object-relational multimedia database managemen...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/(sici)1097-0193(1999)7:2<136::aid-hbm6>3.0
更新日期：1999-01-01 00:00:00
abstract：:In day-to-day life, we need to apply strategies to cascade different actions for efficient unfolding of behavior. While deficits in action cascading are examined extensively, almost nothing is known about the neuronal mechanisms mediating superior performance above the normal level. To examine this question, we invest...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.22530
更新日期：2014-10-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.22576
更新日期：2014-11-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.25143
更新日期：2020-11-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.20762
更新日期：2009-06-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.25030
更新日期：2020-09-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.23418
更新日期：2017-02-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.20519
更新日期：2009-02-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.24554
更新日期：2019-06-15 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.20132
更新日期：2005-05-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.20619
更新日期：2009-05-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/(SICI)1097-0193(1997)5:1<58::AID-HBM6>3.0.
更新日期：1997-01-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.20193
更新日期：2006-06-01 00:00:00
abstract：:Constrained spherical deconvolution (CSD) of diffusion-weighted MRI (DW-MRI) is a popular analysis method that extracts the full white matter (WM) fiber orientation density function (fODF) in the living human brain, noninvasively. It assumes that the DW-MRI signal on the sphere can be represented as the spherical conv...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.25241
更新日期：2020-11-10 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.22079
更新日期：2013-10-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章,多中心研究
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更新日期：2017-01-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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journal_title：Human brain mapping
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更新日期：2018-01-01 00:00:00
