Abstract:
:Both increases and decreases in resting state functional connectivity have been previously observed within the motor network during aging. Moreover, the relationship between altered functional connectivity and age-related declines in bimanual coordination remains unclear. Here, we explored the developmental dynamics of the resting brain within a task-specific motor network in a sample of 128 healthy participants, aged 18-80 years. We found that age-related increases in functional connectivity between interhemispheric dorsal and ventral premotor areas were associated with poorer performance on a novel bimanual visuomotor task. Additionally, a control analysis performed on the default mode network confirmed that our age-related increases in functional connectivity were specific to the motor system. Our findings suggest that increases in functional connectivity within the resting state motor network with aging reflect a loss of functional specialization that may not only occur in the active brain but also in the resting brain.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Solesio-Jofre E,Serbruyns L,Woolley DG,Mantini D,Beets IA,Swinnen SPdoi
10.1002/hbm.22450subject
Has Abstractpub_date
2014-08-01 00:00:00pages
3945-61issue
8eissn
1065-9471issn
1097-0193journal_volume
35pub_type
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