Tracking cerebral blood flow in BOLD fMRI using recursively generated regressors.

Abstract:

:BOLD functional MRI (fMRI) data are dominated by low frequency signals, many of them of unclear origin. We have recently shown that some portions of the low frequency oscillations found in BOLD fMRI are systemic signals closely related to the blood circulation (Tong et al. [2013]: NeuroImage 76:202-215). They are commonly treated as physiological noise in fMRI studies. In this study, we propose and test a novel data-driven analytical method that uses these systemic low frequency oscillations in the BOLD signal as a tracer to follow cerebral blood flow dynamically. Our findings demonstrate that: (1) systemic oscillations pervade the BOLD signal; (2) the temporal traces evolve as the blood propagates though the brain; and, (3) they can be effectively extracted via a recursive procedure and used to derive the cerebral circulation map. Moreover, this method is independent from functional analyses, and thus allows simultaneous and independent assessment of information about cerebral blood flow to be conducted in parallel with the functional studies. In this study, the method was applied to data from the resting state scans, acquired using a multiband EPI sequence (fMRI scan with much shorter TRs), of seven healthy participants. Dynamic maps with consistent features resembling cerebral blood circulation were derived, confirming the robustness and repeatability of the method.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Tong Y,Frederick Bd

doi

10.1002/hbm.22564

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

5471-85

issue

11

eissn

1065-9471

issn

1097-0193

journal_volume

35

pub_type

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