Abstract:
:General cognitive ability (GCA) refers to a trait-like ability that contributes to performance across diverse cognitive tasks. Identifying brain-based markers of GCA has been a longstanding goal of cognitive and clinical neuroscience. Recently, predictive modeling methods have emerged that build whole-brain, distributed neural signatures for phenotypes of interest. In this study, we employ a predictive modeling approach to predict GCA based on fMRI task activation patterns during the N-back working memory task as well as six other tasks in the Human Connectome Project dataset (n = 967), encompassing 15 task contrasts in total. We found tasks are a highly effective basis for prediction of GCA: The 2-back versus 0-back contrast achieved a 0.50 correlation with GCA scores in 10-fold cross-validation, and 13 out of 15 task contrasts afforded statistically significant prediction of GCA. Additionally, we found that task contrasts that produce greater frontoparietal activation and default mode network deactivation-a brain activation pattern associated with executive processing and higher cognitive demand-are more effective in the prediction of GCA. These results suggest a picture analogous to treadmill testing for cardiac function: Placing the brain in a more cognitively demanding task state significantly improves brain-based prediction of GCA.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Sripada C,Angstadt M,Rutherford S,Taxali A,Shedden Kdoi
10.1002/hbm.25007subject
Has Abstractpub_date
2020-08-15 00:00:00pages
3186-3197issue
12eissn
1065-9471issn
1097-0193journal_volume
41pub_type
杂志文章abstract::The preprocessing pipelines typically used in both task and resting-state functional magnetic resonance imaging (rs-fMRI) analysis are modular in nature: They are composed of a number of separate filtering/regression steps, including removal of head motion covariates and band-pass filtering, performed sequentially and...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24528
更新日期:2019-06-01 00:00:00
abstract::The Disrupted in Schizophrenia Gene 1 (DISC1) plays a role in both neural signaling and development and is associated with schizophrenia, although its links to altered brain structure and function in this disorder are not fully established. Here we have used structural and functional MRI to investigate links with six ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22560
更新日期:2014-11-01 00:00:00
abstract::Constrained spherical deconvolution (CSD) of diffusion-weighted MRI (DW-MRI) is a popular analysis method that extracts the full white matter (WM) fiber orientation density function (fODF) in the living human brain, noninvasively. It assumes that the DW-MRI signal on the sphere can be represented as the spherical conv...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25241
更新日期:2020-11-10 00:00:00
abstract::Active listening has been reported to elicit a different sensory response from passive listening and is generally observed as an increase in the magnitude of activation. Sensory activation differences may therefore be masked by the effect of attention. The present study measured activation induced by static and modula...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract::This study investigated the cortical responses underlying magnitude comparisons of multisensory stimuli and examined the effect that musical expertise has in this process. The comparative judgments were based on a newly learned rule binding the auditory and visual stimuli within the context of magnitude comparisons: "...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22558
更新日期:2014-11-01 00:00:00
abstract::In contrast to conventional functional magnetic resonance imaging (fMRI) analysis across participants, item analysis allows generalizing the observed neural response patterns from a specific stimulus set to the entire population of stimuli. In the present study, we perform an item analysis on an fMRI paradigm (EmpaToM...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24966
更新日期:2020-07-01 00:00:00
abstract::Action observation leads to the automatic activation of the corresponding motor representation in the observer through "mirror-matching." This constitutes a "shared representational system," which is thought to subserve social understanding by motor simulation. However, it is unclear how these shared representations c...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20800
更新日期:2009-11-01 00:00:00
abstract::Affective temperaments have been described since the early 20th century and may play a central role in psychiatric illnesses, such as bipolar disorder (BD). However, the neuronal basis of temperament is still unclear. We investigated the relationship of temperament with neuronal variability in the resting state signal...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24453
更新日期:2019-03-01 00:00:00
abstract::Fetal alcohol spectrum disorders comprise the spectrum of cognitive, behavioral, and neurological impairments caused by prenatal alcohol exposure (PAE). Diffusion tensor imaging (DTI) was performed on 54 children (age 10.1 ± 1.0 years) from the Cape Town Longitudinal Cohort, for whom detailed drinking histories obtain...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23218
更新日期:2016-08-01 00:00:00
abstract::Two new directions of functional connectivity investigation are emerging to advance studies of the brain's functional organization. First, the identification of task-related dynamics of functional connectivity has elicited a growing interest in characterizing the brain's functional reorganization due to task demands. ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22847
更新日期:2015-08-01 00:00:00
abstract::Bimanual movements involve the interactions between both primary motor cortices. These interactions are assumed to involve phase-locked oscillatory brain activity referred to as inter-hemispheric functional coupling. So far, inter-hemispheric functional coupling has been investigated as a function of motor performance...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23663
更新日期:2017-09-01 00:00:00
abstract::The sudden onset of a face image leads to a prominent face-selective response in human scalp electroencephalographic (EEG) recordings, peaking 170 ms after stimulus onset at occipito-temporal (OT) scalp sites: the N170 (or M170 in magnetoencephalography). According to a widely held view, the main cortical source of th...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24455
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVES:Recovery of independent ambulation after stroke is a major goal. However, which rehabilitation regimen best benefits each individual is unknown and decisions are currently made on a subjective basis. Predictors of response to specific therapies would guide the type of therapy most appropriate for each patien...
journal_title:Human brain mapping
pub_type: 杂志文章,随机对照试验
doi:10.1002/hbm.23059
更新日期:2016-02-01 00:00:00
abstract::Infants born prematurely are at increased risk of adverse neurodevelopmental outcome. The measurement of white matter tissue composition and structure can help predict functional performance. Specifically, measurements of myelination and indicators of myelination status in the preterm brain could be predictive of late...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23188
更新日期:2016-07-01 00:00:00
abstract::There is good evidence from animal studies for segregation in the processing of non-nociceptive and nociceptive information within the trigeminal brainstem sensory nuclear complex. However, it remains unknown whether a similar segregation occurs in humans, and a recent tract tracing study suggests that this segregatio...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20805
更新日期:2009-11-01 00:00:00
abstract::Research in amyotrophic lateral sclerosis (ALS) suggests that executive dysfunction, a prevalent cognitive feature of the disease, is associated with abnormal structural connectivity and white matter integrity. In this exploratory study, we investigated the white matter constructs of executive dysfunction, and attempt...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23452
更新日期:2017-03-01 00:00:00
abstract::BOLD functional MRI (fMRI) data are dominated by low frequency signals, many of them of unclear origin. We have recently shown that some portions of the low frequency oscillations found in BOLD fMRI are systemic signals closely related to the blood circulation (Tong et al. [2013]: NeuroImage 76:202-215). They are comm...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22564
更新日期:2014-11-01 00:00:00
abstract::The theory of material specific lateralization of memory function posits that left and right MTL regions are asymmetrically involved in mnemonic processing of verbal and nonverbal material respectively. Lesion and functional imaging (fMRI) studies provide robust evidence for a left MTL asymmetry in the verbal memory d...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23077
更新日期:2016-03-01 00:00:00
abstract::Recent studies have shown that resting-state functional networks as studied with fMRI, EEG, and MEG may be so-called small-world networks. We investigated to what extent the characteristic features of small-world networks are genetically determined. To represent functional connectivity between brain areas, we measured...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20468
更新日期:2008-12-01 00:00:00
abstract::Low frequency theta band oscillations (4-8 Hz) are thought to provide a timing mechanism for hippocampal place cell firing and to mediate the formation of spatial memory. In rodents, hippocampal theta has been shown to play an important role in encoding a new environment during spatial navigation, but a similar functi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23458
更新日期:2017-03-01 00:00:00
abstract::Recent studies have investigated the neural correlates of how we perceive emotions of individuals or a group of individuals using images of individual bodily expressions. However, it is still largely unknown how we perceive the emotion of a dynamic crowd. This fMRI study used realistic videos of a large group of peopl...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22774
更新日期:2015-06-01 00:00:00
abstract::Although much has been learned about the functional organization of the human brain through lesion-deficit analysis, the variety of statistical and image-processing methods developed for this purpose precludes a closed-form analysis of the statistical power of these systems. Therefore, we developed a lesion-deficit si...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(sici)1097-0193(200006)10:2<61::aid-hbm20>
更新日期:2000-06-01 00:00:00
abstract:INTRODUCTION:Cortical thickness mapping is a widely used method for the analysis of neuroanatomical differences between subject groups. We applied power analysis methods over a range of image processing parameters to derive a model that allows researchers to calculate the number of subjects required to ensure a well-po...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22120
更新日期:2013-11-01 00:00:00
abstract::Experienced video game players exhibit superior performance in visuospatial cognition when compared to non-players. However, very little is known about the relation between video game experience and structural brain plasticity. To address this issue, a direct comparison of the white matter brain structure in RTS (real...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24208
更新日期:2018-09-01 00:00:00
abstract::We describe a method for the statistical parametric mapping of low resolution electromagnetic tomography (LORETA) using high-density electroencephalography (EEG) and individual magnetic resonance images (MRI) to investigate the characteristics of the mismatch negativity (MMN) generators in schizophrenia. LORETA, using...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.10059
更新日期:2002-11-01 00:00:00
abstract::The neurons of the human cerebral cortex are arranged in a highly folded sheet, with the majority of the cortical surface area buried in folds. Cortical maps are typically arranged with a topography oriented parallel to the cortical surface. Despite this unambiguous sheetlike geometry, the most commonly used coordinat...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(sici)1097-0193(1999)8:4<272::aid-hbm10>3.
更新日期:1999-01-01 00:00:00
abstract::Gait disturbances, including freezing of gait, are frequent and disabling symptoms of Parkinson's disease. They often respond poorly to dopaminergic treatments. Although recent studies have shed some light on their neural correlates, their modulation by dopaminergic treatment remains quite unknown. Specifically, the i...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22679
更新日期:2015-03-01 00:00:00
abstract::Spatial leakage effects are particularly confounding for seed-based investigations of brain networks using source-level electroencephalography (EEG) or magnetoencephalography (MEG). Various methods designed to avoid this issue have been introduced but are limited to particular assumptions about its temporal characteri...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22943
更新日期:2015-11-01 00:00:00
abstract::Incongruent auditory and visual stimuli can elicit audiovisual illusions such as the McGurk effect where visual /ka/ and auditory /pa/ fuse into another percept such as/ta/. In the present study, human brain activity was measured with adaptation functional magnetic resonance imaging to investigate which brain areas su...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20884
更新日期:2010-04-01 00:00:00
abstract::Multivariate functional connectivity analyses of neuroimaging data have revealed the importance of complex, distributed interactions between disparate yet interdependent brain regions. Recent work has shown that topological properties of functional brain networks are associated with individual and group differences in...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23518
更新日期:2017-04-01 00:00:00