Abstract:
:Fetal alcohol spectrum disorders comprise the spectrum of cognitive, behavioral, and neurological impairments caused by prenatal alcohol exposure (PAE). Diffusion tensor imaging (DTI) was performed on 54 children (age 10.1 ± 1.0 years) from the Cape Town Longitudinal Cohort, for whom detailed drinking histories obtained during pregnancy are available: 26 with full fetal alcohol syndrome (FAS) or partial FAS (PFAS), 15 nonsyndromal heavily exposed (HE), and 13 controls. Using voxelwise analyses, children with FAS/PFAS showed significantly lower fractional anisotropy (FA) in four white matter (WM) regions and higher mean diffusivity (MD) in seven; three regions of FA and MD differences (left inferior longitudinal fasciculus (ILF), splenium, and isthmus) overlapped, and the fourth FA cluster was located in the same WM bundle (right ILF) as an MD cluster. HE children showed lower FA and higher MD in a subset of these regions. Significant correlations were observed between three continuous alcohol measures and DTI values at cluster peaks, indicating that WM damage in several regions is dose dependent. Lower FA in the regions of interest was attributable primarily to increased radial diffusivity rather than decreased axonal diffusivity, suggesting poorer axon packing density and/or myelination. Multiple regression models indicated that this cortical WM impairment partially mediated adverse effects of PAE on information processing speed and eyeblink conditioning. Hum Brain Mapp 37:2943-2958, 2016. © 2016 Wiley Periodicals, Inc.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Fan J,Jacobson SW,Taylor PA,Molteno CD,Dodge NC,Stanton ME,Jacobson JL,Meintjes EMdoi
10.1002/hbm.23218subject
Has Abstractpub_date
2016-08-01 00:00:00pages
2943-58issue
8eissn
1065-9471issn
1097-0193journal_volume
37pub_type
杂志文章abstract::Posttraumatic stress disorder (PTSD) is a prevalent, debilitating, and difficult to treat psychiatric disorder. Very little is known of how PTSD affects neuroplasticity in the developing adolescent brain. Whereas multiple lines of research implicate amygdala-centered network dysfunction in the pathophysiology of adult...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23093
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journal_title:Human brain mapping
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abstract::The neurobiological basis of reading is of considerable interest, yet analyzing data from subjects reading words aloud during functional MRI data collection can be difficult. Therefore, many investigators use surrogate tasks such as visual matching or rhyme matching to eliminate the need for spoken output. Use of thes...
journal_title:Human brain mapping
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journal_title:Human brain mapping
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journal_title:Human brain mapping
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journal_title:Human brain mapping
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20217
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journal_title:Human brain mapping
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journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25241
更新日期:2020-11-10 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22514
更新日期:2014-09-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21302
更新日期:2012-07-01 00:00:00
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doi:10.1002/hbm.24807
更新日期:2020-02-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23458
更新日期:2017-03-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24679
更新日期:2019-09-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21035
更新日期:2011-03-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章,评审
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journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Human brain mapping
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.20671
更新日期:2009-08-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21446
更新日期:2013-02-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21223
更新日期:2012-02-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23259
更新日期:2016-10-01 00:00:00
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journal_title:Human brain mapping
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