White matter deficits mediate effects of prenatal alcohol exposure on cognitive development in childhood.

Abstract:

:Fetal alcohol spectrum disorders comprise the spectrum of cognitive, behavioral, and neurological impairments caused by prenatal alcohol exposure (PAE). Diffusion tensor imaging (DTI) was performed on 54 children (age 10.1 ± 1.0 years) from the Cape Town Longitudinal Cohort, for whom detailed drinking histories obtained during pregnancy are available: 26 with full fetal alcohol syndrome (FAS) or partial FAS (PFAS), 15 nonsyndromal heavily exposed (HE), and 13 controls. Using voxelwise analyses, children with FAS/PFAS showed significantly lower fractional anisotropy (FA) in four white matter (WM) regions and higher mean diffusivity (MD) in seven; three regions of FA and MD differences (left inferior longitudinal fasciculus (ILF), splenium, and isthmus) overlapped, and the fourth FA cluster was located in the same WM bundle (right ILF) as an MD cluster. HE children showed lower FA and higher MD in a subset of these regions. Significant correlations were observed between three continuous alcohol measures and DTI values at cluster peaks, indicating that WM damage in several regions is dose dependent. Lower FA in the regions of interest was attributable primarily to increased radial diffusivity rather than decreased axonal diffusivity, suggesting poorer axon packing density and/or myelination. Multiple regression models indicated that this cortical WM impairment partially mediated adverse effects of PAE on information processing speed and eyeblink conditioning. Hum Brain Mapp 37:2943-2958, 2016. © 2016 Wiley Periodicals, Inc.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Fan J,Jacobson SW,Taylor PA,Molteno CD,Dodge NC,Stanton ME,Jacobson JL,Meintjes EM

doi

10.1002/hbm.23218

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

2943-58

issue

8

eissn

1065-9471

issn

1097-0193

journal_volume

37

pub_type

杂志文章
  • Abnormal functional architecture of amygdala-centered networks in adolescent posttraumatic stress disorder.

    abstract::Posttraumatic stress disorder (PTSD) is a prevalent, debilitating, and difficult to treat psychiatric disorder. Very little is known of how PTSD affects neuroplasticity in the developing adolescent brain. Whereas multiple lines of research implicate amygdala-centered network dysfunction in the pathophysiology of adult...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23093

    authors: Aghajani M,Veer IM,van Hoof MJ,Rombouts SA,van der Wee NJ,Vermeiren RR

    更新日期:2016-03-01 00:00:00

  • A somatosensory-to-motor cascade of cortical areas engaged in perceptual decision making during tactile pattern discrimination.

    abstract::The processes underlying perceptual decision making are diverse and typically engage a distributed network of brain areas. It is a particular challenge to establish a sensory-to-motor functional hierarchy in such networks. This is because single-cell recordings mainly study the nodes of decision networks in isolation ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23446

    authors: Hegner YL,Lindner A,Braun C

    更新日期:2017-03-01 00:00:00

  • Matching is not naming: a direct comparison of lexical manipulations in explicit and implicit reading tasks.

    abstract::The neurobiological basis of reading is of considerable interest, yet analyzing data from subjects reading words aloud during functional MRI data collection can be difficult. Therefore, many investigators use surrogate tasks such as visual matching or rhyme matching to eliminate the need for spoken output. Use of thes...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22077

    authors: Vogel AC,Petersen SE,Schlaggar BL

    更新日期:2013-10-01 00:00:00

  • Functional integrity in children with anoxic brain injury from drowning.

    abstract::Drowning is a leading cause of accidental injury and death in young children. Anoxic brain injury (ABI) is a common consequence of drowning and can cause severe neurological morbidity in survivors. Assessment of functional status and prognostication in drowning victims can be extremely challenging, both acutely and ch...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23745

    authors: Ishaque M,Manning JH,Woolsey MD,Franklin CG,Tullis EW,Beckmann CF,Fox PT

    更新日期:2017-10-01 00:00:00

  • Subcortical structural variations associated with low socioeconomic status in adolescents.

    abstract::Low socioeconomic status (SES) is associated with a higher probability of multiple exposures (e.g., neighborhood violence, poor nutrition, housing instability, air pollution, and insensitive caregiving) known to affect structural development of subcortical brain regions that subserve threat and reward processing, howe...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24796

    authors: Jenkins LM,Chiang JJ,Vause K,Hoffer L,Alpert K,Parrish TB,Wang L,Miller GE

    更新日期:2020-01-01 00:00:00

  • Individual resting-state frontocingular functional connectivity predicts the intermittent theta burst stimulation response to stress in healthy female volunteers.

    abstract::Intermittent theta burst stimulation (iTBS) delivered to the dorsolateral prefrontal cortex (DLPFC) has been investigated as a promising treatment for stress and stress-related mental disorders such as major depression, yet large individual differences in responsiveness demand further exploration and optimization of i...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.25193

    authors: de Wandel L,Pulopulos MM,Labanauskas V,de Witte S,Vanderhasselt MA,Baeken C

    更新日期:2020-12-15 00:00:00

  • Altered functional connectivity of primary visual cortex in early blindness.

    abstract::In early blindness, the primary visual area (PVA) loses the ability to process visual information, and shifts to working on the processing of somatosensory input, auditory input, and some higher-level cognitive functions. It has not yet been investigated whether such functional changes can lead to alterations of the f...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20420

    authors: Yu C,Liu Y,Li J,Zhou Y,Wang K,Tian L,Qin W,Jiang T,Li K

    更新日期:2008-05-01 00:00:00

  • Potential of on-scalp MEG: Robust detection of human visual gamma-band responses.

    abstract::Electrophysiological signals recorded intracranially show rich frequency content spanning from near-DC to hundreds of hertz. Noninvasive electromagnetic signals measured with electroencephalography (EEG) or magnetoencephalography (MEG) typically contain less signal power in high frequencies than invasive recordings. P...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24795

    authors: Iivanainen J,Zetter R,Parkkonen L

    更新日期:2020-01-01 00:00:00

  • Neural activity related to self- versus externally generated painful stimuli reveals distinct differences in the lateral pain system in a parametric fMRI study.

    abstract::Self-generated sensory stimulation can be distinguished from externally generated stimulation that is otherwise identical. To determine how the brain differentiates external from self-generated noxious stimulation and which structures of the lateral pain system use neural signals to predict the sensory consequences of...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20217

    authors: Helmchen C,Mohr C,Erdmann C,Binkofski F,Büchel C

    更新日期:2006-09-01 00:00:00

  • The mirror neuron system and the strange case of Broca's area.

    abstract::Mirror neurons, originally described in the monkey premotor area F5, are embedded in a frontoparietal network for action execution and observation. A similar Mirror Neuron System (MNS) exists in humans, including precentral gyrus, inferior parietal lobule, and superior temporal sulcus. Controversial is the inclusion o...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22682

    authors: Cerri G,Cabinio M,Blasi V,Borroni P,Iadanza A,Fava E,Fornia L,Ferpozzi V,Riva M,Casarotti A,Martinelli Boneschi F,Falini A,Bello L

    更新日期:2015-03-01 00:00:00

  • Development of hippocampal subfield volumes from 4 to 22 years.

    abstract::The hippocampus supports several important cognitive functions known to undergo substantial development during childhood and adolescence, for example, encoding and consolidation of vivid personal memories. However, diverging developmental effects on hippocampal volume have been observed across studies. It is possible ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22576

    authors: Krogsrud SK,Tamnes CK,Fjell AM,Amlien I,Grydeland H,Sulutvedt U,Due-Tønnessen P,Bjørnerud A,Sølsnes AE,Håberg AK,Skrane J,Walhovd KB

    更新日期:2014-11-01 00:00:00

  • Evidence for a general performance-monitoring system in the human brain.

    abstract::Adaptive behavior relies on the ability of the brain to form predictions and monitor action outcomes. In the human brain, the same system is thought to monitor action outcomes regardless of whether the information originates from internal (e.g., proprioceptive) and external (e.g., visual) sensory channels. Neural sign...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24273

    authors: Zubarev I,Parkkonen L

    更新日期:2018-11-01 00:00:00

  • Modality specific functional interaction in sensorimotor synchronization.

    abstract::Movement execution strongly relies on precise sensorimotor synchronization. In a finger-tapping task that requires subjects to synchronize their finger taps to regular pacing signal synchronization accuracy varies with respect to pacing signal's modality. This study aimed at elucidating functional brain dynamics assoc...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20762

    authors: Pollok B,Krause V,Butz M,Schnitzler A

    更新日期:2009-06-01 00:00:00

  • Constrained spherical deconvolution of nonspherically sampled diffusion MRI data.

    abstract::Constrained spherical deconvolution (CSD) of diffusion-weighted MRI (DW-MRI) is a popular analysis method that extracts the full white matter (WM) fiber orientation density function (fODF) in the living human brain, noninvasively. It assumes that the DW-MRI signal on the sphere can be represented as the spherical conv...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.25241

    authors: Morez J,Sijbers J,Vanhevel F,Jeurissen B

    更新日期:2020-11-10 00:00:00

  • Early life trauma and directional brain connectivity within major depression.

    abstract:OBJECTIVE:Early life trauma (ELT) is a significant risk factor for the onset of depression. Emerging findings indicate ELT is associated with enhanced amygdala reactivity to aversive stimuli in never-depressed healthy controls as well as those with acute depression but may be absent in non-ELT exposed depressed. The pr...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22514

    authors: Grant MM,White D,Hadley J,Hutcheson N,Shelton R,Sreenivasan K,Deshpande G

    更新日期:2014-09-01 00:00:00

  • Tract-based magnetic resonance spectroscopy of the cingulum bundles at 7 T.

    abstract::The cingulum bundle is a white matter fiber bundle in the human brain that is believed to be implicated in various neurological and psychiatric diseases. Subtle disease-related differences in metabolite concentrations in the cingulum tracts that may underlie these diseases may be detected using MR spectroscopic inform...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21302

    authors: Mandl RC,van den Heuvel MP,Klomp DW,Boer VO,Siero JC,Luijten PR,Hulshoff Pol HE

    更新日期:2012-07-01 00:00:00

  • Temporal stability of functional brain modules associated with human intelligence.

    abstract::Individual differences in general cognitive ability (i.e., intelligence) have been linked to individual variations in the modular organization of functional brain networks. However, these analyses have been limited to static (time-averaged) connectivity, and have not yet addressed whether dynamic changes in the config...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24807

    authors: Hilger K,Fukushima M,Sporns O,Fiebach CJ

    更新日期:2020-02-01 00:00:00

  • The functional role of human right hippocampal/parahippocampal theta rhythm in environmental encoding during virtual spatial navigation.

    abstract::Low frequency theta band oscillations (4-8 Hz) are thought to provide a timing mechanism for hippocampal place cell firing and to mediate the formation of spatial memory. In rodents, hippocampal theta has been shown to play an important role in encoding a new environment during spatial navigation, but a similar functi...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23458

    authors: Pu Y,Cornwell BR,Cheyne D,Johnson BW

    更新日期:2017-03-01 00:00:00

  • Multimodal imaging reveals a complex pattern of dysfunction in corticolimbic pathways in major depressive disorder.

    abstract::Major depressive disorder (MDD) is highly prevalent and associated with considerable morbidity, yet its pathophysiology remains only partially understood. While numerous studies have investigated the neurobiological correlates of MDD, most have used only a single neuroimaging modality. In particular, diffusion tensor ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24679

    authors: Nugent AC,Farmer C,Evans JW,Snider SL,Banerjee D,Zarate CA Jr

    更新日期:2019-09-01 00:00:00

  • The vomeronasal organ is not involved in the perception of endogenous odors.

    abstract::Chemosensory-based communication is a vital signaling tool in most species, and evidence has recently emerged in support of the notion that humans also use social chemosignals (so-called pheromones) to communicate. An ongoing controversy does exist, however, concerning the receptor organ through which these chemicals ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21035

    authors: Frasnelli J,Lundström JN,Boyle JA,Katsarkas A,Jones-Gotman M

    更新日期:2011-03-01 00:00:00

  • Transcranial magnetic stimulation during PET: reaching and verifying the target site.

    abstract::Transcranial magnetic stimulation (TMS) during positron emission tomography (PET) is a novel technique for in vivo measurements of connectivity and excitability of the human cerebral cortex. Here we describe tools that allow investigators to position the stimulating coil over a target region and to verify the actual p...

    journal_title:Human brain mapping

    pub_type: 杂志文章,评审

    doi:

    authors: Paus T,Wolforth M

    更新日期:1998-01-01 00:00:00

  • Mapping the structural and functional network architecture of the medial temporal lobe using 7T MRI.

    abstract::Medial temporal lobe (MTL) subregions play integral roles in memory function and are differentially affected in various neurological and psychiatric disorders. The ability to structurally and functionally characterize these subregions may be important to understanding MTL physiology and diagnosing diseases involving t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23887

    authors: Shah P,Bassett DS,Wisse LEM,Detre JA,Stein JM,Yushkevich PA,Shinohara RT,Pluta JB,Valenciano E,Daffner M,Wolk DA,Elliott MA,Litt B,Davis KA,Das SR

    更新日期:2018-02-01 00:00:00

  • Regional cerebral blood flow in children with attention deficit hyperactivity disorder: comparison before and after methylphenidate treatment.

    abstract::Differences in brain activity of children with attention deficit hyperactivity disorder (ADHD) have been compared to normal healthy controls, suggesting neural correlates of cognitive/behavioral symptoms. Symptoms are improved with methylphenidate treatment but limited sources can be cited to show how brain activity i...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20067

    authors: Lee JS,Kim BN,Kang E,Lee DS,Kim YK,Chung JK,Lee MC,Cho SC

    更新日期:2005-03-01 00:00:00

  • Cortical thickness is not associated with current depression in a clinical treatment study.

    abstract:BACKGROUND:Reduced cortical thickness is a candidate biological marker of depression, although findings are inconsistent. This could reflect analytic heterogeneity, such as use of region-wise cortical thickness based on the Freesurfer Desikan-Killiany (DK) atlas or surface-based morphometry (SBM). The Freesurfer Destri...

    journal_title:Human brain mapping

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/hbm.23664

    authors: Perlman G,Bartlett E,DeLorenzo C,Weissman M,McGrath P,Ogden T,Jin T,Adams P,Trivedi M,Kurian B,Oquendo M,McInnis M,Weyandt S,Fava M,Cooper C,Malchow A,Parsey R

    更新日期:2017-09-01 00:00:00

  • Optimization of retinotopy constrained source estimation constrained by prior.

    abstract::Studying how the timing and amplitude of visual evoked responses (VERs) vary between visual areas is important for understanding visual processing but is complicated by difficulties in reliably estimating VERs in individual visual areas using noninvasive brain measurements. Retinotopy constrained source estimation (RC...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22293

    authors: Hagler DJ Jr

    更新日期:2014-05-01 00:00:00

  • Are there theory of mind regions in the brain? A review of the neuroimaging literature.

    abstract::There have been many functional imaging studies of the brain basis of theory of mind (ToM) skills, but the findings are heterogeneous and implicate anatomical regions as far apart as orbitofrontal cortex and the inferior parietal lobe. The functional imaging studies are reviewed to determine whether the diverse findin...

    journal_title:Human brain mapping

    pub_type: 杂志文章,评审

    doi:10.1002/hbm.20671

    authors: Carrington SJ,Bailey AJ

    更新日期:2009-08-01 00:00:00

  • Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence.

    abstract:BACKGROUND:Trait impulsiveness is a potential factor that predicts both substance use and certain psychiatric disorders. This study investigates whether there are common structural cerebral correlates of trait impulsiveness and cognitive functioning in a large sample of healthy adolescents from the IMAGEN project. MET...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21446

    authors: Schilling C,Kühn S,Romanowski A,Banaschewski T,Barbot A,Barker GJ,Brühl R,Büchel C,Charlet K,Conrod PJ,Czech K,Dalley JW,Flor H,Häke I,Ittermann B,Ivanov N,Mann K,Lüdemann K,Martinot JL,Palafox C,Paus T,Poline J

    更新日期:2013-02-01 00:00:00

  • Individual variability in the shape and amplitude of the BOLD-HRF correlates with endogenous GABAergic inhibition.

    abstract::It has previously been demonstrated that there is a negative correlation between the amplitude of the BOLD response and resting γ amino-butyric acid (GABA) concentration in visual cortex. The work here is the first to empirically characterize individual variability in the haemodynamic response functions (HRFs) in resp...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21223

    authors: Muthukumaraswamy SD,Evans CJ,Edden RA,Wise RG,Singh KD

    更新日期:2012-02-01 00:00:00

  • A Comparison of the neural correlates that underlie rule-based and information-integration category learning.

    abstract::The influential competition between verbal and implicit systems (COVIS) model proposes that category learning is driven by two competing neural systems-an explicit, verbal, system, and a procedural-based, implicit, system. In the current fMRI study, participants learned either a conjunctive, rule-based (RB), category ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23259

    authors: Carpenter KL,Wills AJ,Benattayallah A,Milton F

    更新日期:2016-10-01 00:00:00

  • Measurement of cortical thickness from MRI by minimum line integrals on soft-classified tissue.

    abstract::Estimating the thickness of the cerebral cortex is a key step in many brain imaging studies, revealing valuable information on development or disease progression. In this work, we present a framework for measuring the cortical thickness, based on minimizing line integrals over the probability map of the gray matter in...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20740

    authors: Aganj I,Sapiro G,Parikshak N,Madsen SK,Thompson PM

    更新日期:2009-10-01 00:00:00