Abstract:
:Individual differences in general cognitive ability (i.e., intelligence) have been linked to individual variations in the modular organization of functional brain networks. However, these analyses have been limited to static (time-averaged) connectivity, and have not yet addressed whether dynamic changes in the configuration of brain networks relate to general intelligence. Here, we used multiband functional MRI resting-state data (N = 281) and estimated subject-specific time-varying functional connectivity networks. Modularity optimization was applied to determine individual time-variant module partitions and to assess fluctuations in modularity across time. We show that higher intelligence, indexed by an established composite measure, the Wechsler Abbreviated Scale of Intelligence (WASI), is associated with higher temporal stability (lower temporal variability) of brain network modularity. Post-hoc analyses reveal that subjects with higher intelligence scores engage in fewer periods of extremely high modularity - which are characterized by greater disconnection of task-positive from task-negative networks. Further, we show that brain regions of the dorsal attention network contribute most to the observed effect. In sum, our study suggests that investigating the temporal dynamics of functional brain network topology contributes to our understanding of the neural bases of general cognitive abilities.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Hilger K,Fukushima M,Sporns O,Fiebach CJdoi
10.1002/hbm.24807subject
Has Abstractpub_date
2020-02-01 00:00:00pages
362-372issue
2eissn
1065-9471issn
1097-0193journal_volume
41pub_type
杂志文章abstract::Children born very preterm (VPT; <32 weeks' gestational age) are at high risk for emotional regulation and social communication impairments. However, the underlying neurobiological correlates of these difficulties remain poorly understood. Using a multimodal approach, including both magnetoencephalographic and structu...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24604
更新日期:2019-08-01 00:00:00
abstract::Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF) and between-subject variation of Hct thus causes variation in task-based BOLD fMRI signal changes. We first verified in healthy volunteers (n = 12) that Hct values can be derived reliably from venous blood T1 values by compariso...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23846
更新日期:2018-01-01 00:00:00
abstract::Behavioral evidence and theory suggest gesture and language processing may be part of a shared cognitive system for communication. While much research demonstrates both gesture and language recruit regions along perisylvian cortex, relatively less work has tested functional segregation within these regions on an indiv...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23251
更新日期:2016-10-01 00:00:00
abstract::Human neuroimaging studies have increasingly converged on the possibility that the neural representation of specific numbers may be decodable from brain activity, particularly in parietal cortex. Multivariate machine learning techniques have recently demonstrated that the neural representation of individual concrete n...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22087
更新日期:2013-10-01 00:00:00
abstract::Affective temperaments have been described since the early 20th century and may play a central role in psychiatric illnesses, such as bipolar disorder (BD). However, the neuronal basis of temperament is still unclear. We investigated the relationship of temperament with neuronal variability in the resting state signal...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24453
更新日期:2019-03-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) were used to map brain activation during language tasks. While previous studies have compared performance between alphabetic literate and illiterate subjects, there have been no such data in Chinese-speaking individuals. In this study,...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20173
更新日期:2006-02-01 00:00:00
abstract::It is becoming common to collect data from multiple functional magnetic resonance imaging (fMRI) paradigms on a single individual. The data from these experiments are typically analyzed separately and sometimes directly subtracted from one another on a voxel-by-voxel basis. These comparative approaches, although usefu...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20204
更新日期:2006-07-01 00:00:00
abstract::Neural dynamics can shape human experience, including pain. Pain has been linked to dynamic functional connectivity within and across brain regions of the dynamic pain connectome (consisting of the ascending nociceptive pathway (Asc), descending antinociceptive pathway (Desc), salience network (SN), and the default mo...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25245
更新日期:2021-02-15 00:00:00
abstract::Accumulating evidence suggests that early improvement after two-week antidepressant treatment is predictive of later outcomes of patients with major depressive disorder (MDD); however, whether this early improvement is associated with baseline neural architecture remains largely unknown. Utilizing resting-state functi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22817
更新日期:2015-08-01 00:00:00
abstract::Depressive symptoms often coexist with memory deficits in older adults and also are associated with incident cognitive decline in the elderly. However, little is known about the neural correlates of the association between depressive symptoms and memory deficits in nondemented elderly. Fifteen amnestic mild cognitive ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21291
更新日期:2012-06-01 00:00:00
abstract::Transcranial magnetic stimulation (TMS) during positron emission tomography (PET) is a novel technique for in vivo measurements of connectivity and excitability of the human cerebral cortex. Here we describe tools that allow investigators to position the stimulating coil over a target region and to verify the actual p...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disorder with dysfunction in cortices as well as white matter (WM) tracts. While the changes to WM structure have been extensively investigated in PD, the nature of the functional changes to WM remains unknown. In this study, the regional activity and functional connecti...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24444
更新日期:2019-03-01 00:00:00
abstract::Playing music requires a strong coupling of perception and action mediated by multimodal integration of brain regions, which can be described as network connections measured by anatomical and functional correlations between regions. However, the structural and functional connectivities within and between the auditory ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23989
更新日期:2018-05-01 00:00:00
abstract::Several methods are available for the identification of functional networks of brain areas using functional magnetic resonance imaging (fMRI) time-series. These typically assume a fixed relationship between the signal of the areas belonging to the same network during the entire time-series (e.g., positive correlation ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22852
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Abnormalities in inhibitory control and underlying fronto-striatal networks is common to both attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive-disorder (OCD). The aim of this study was to investigate disorder-specific abnormalities in neural networks mediating interference inhibition ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21048
更新日期:2011-04-01 00:00:00
abstract::Classically, model-based segmentation procedures match magnetic resonance imaging (MRI) volumes to an expertly labeled atlas using nonlinear registration. The accuracy of these techniques are limited due to atlas biases, misregistration, and resampling error. Multi-atlas-based approaches are used as a remedy and invol...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22092
更新日期:2013-10-01 00:00:00
abstract::The concept of brain maintenance refers to the preservation of brain integrity in older age, while cognitive reserve refers to the capacity to maintain cognition in the presence of neurodegeneration or aging-related brain changes. While both mechanisms are thought to contribute to individual differences in cognitive f...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25316
更新日期:2020-12-14 00:00:00
abstract::Fetal alcohol spectrum disorders comprise the spectrum of cognitive, behavioral, and neurological impairments caused by prenatal alcohol exposure (PAE). Diffusion tensor imaging (DTI) was performed on 54 children (age 10.1 ± 1.0 years) from the Cape Town Longitudinal Cohort, for whom detailed drinking histories obtain...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23218
更新日期:2016-08-01 00:00:00
abstract::Brain morphometry based classification from magnetic resonance (MR) acquisitions has been widely investigated in the diagnosis of Alzheimer's disease (AD) and its prodromal stage, i.e., mild cognitive impairment (MCI). In the literature, a morphometric representation of brain structures is obtained by spatial normaliz...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22531
更新日期:2014-10-01 00:00:00
abstract::Adaptive behavior relies on the ability of the brain to form predictions and monitor action outcomes. In the human brain, the same system is thought to monitor action outcomes regardless of whether the information originates from internal (e.g., proprioceptive) and external (e.g., visual) sensory channels. Neural sign...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24273
更新日期:2018-11-01 00:00:00
abstract::The registration of image volumes derived from different imaging modalities such as MRI, PET, SPECT, and CT has been described in numerous studies in which functional and morphological data are combined on the basis of macrostructural information. However, the exact topography of architectural details is defined by mi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Characterizing the neurovascular coupling between hemodynamic signals and their neural origins is crucial to functional neuroimaging research, even more so as new methods become available for integrating results from different functional neuroimaging modalities. We present a novel method to relate magnetoencephalograp...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20361
更新日期:2008-01-01 00:00:00
abstract::Magnetic resonance imaging of subcortical gray matter structures, which mediate behavior, cognition and the pathophysiology of several diseases, is crucial for establishing typical maturation patterns across the human lifespan. This single site study examines T1-weighted MPRAGE images of 3 healthy cohorts: (i) a cross...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23604
更新日期:2017-08-01 00:00:00
abstract::Past research has found that neural activity associated with feedback processing is enhanced by positive approach-motivated states. However, no past work has examined how reward processing changes in the context of revenge. Using a novel aggression paradigm, we sought to explore the influence of approach-motivated ang...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25177
更新日期:2020-12-01 00:00:00
abstract::This study examined global resting-state functional connectivity of neural oscillations in individuals with chronic tinnitus and normal and impaired hearing. We tested the hypothesis that distinct neural oscillatory networks are engaged in tinnitus with and without hearing loss. In both tinnitus groups, with and witho...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24981
更新日期:2020-07-01 00:00:00
abstract::In contrast to conventional functional magnetic resonance imaging (fMRI) analysis across participants, item analysis allows generalizing the observed neural response patterns from a specific stimulus set to the entire population of stimuli. In the present study, we perform an item analysis on an fMRI paradigm (EmpaToM...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24966
更新日期:2020-07-01 00:00:00
abstract::Pramipexole is widely prescribed to treat Parkinson's disease. It has been found to cause impulse control disorders such as pathological gambling. To examine how pramipexole modulates the network of reward anticipation, we carried out a pharmacological functional magnetic resonance imaging study with a double-blind, w...
journal_title:Human brain mapping
pub_type: 杂志文章,随机对照试验
doi:10.1002/hbm.21067
更新日期:2011-05-01 00:00:00
abstract::Studying how the timing and amplitude of visual evoked responses (VERs) vary between visual areas is important for understanding visual processing but is complicated by difficulties in reliably estimating VERs in individual visual areas using noninvasive brain measurements. Retinotopy constrained source estimation (RC...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22293
更新日期:2014-05-01 00:00:00
abstract::Cortical hubs play a fundamental role in the functional architecture of brain connectivity at rest. However, the anatomical scaffold underlying their centrality is still under debate. Certainly, the brain function and anatomy are significantly entwined through synaptogenesis and pruning mechanisms that continuously re...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23721
更新日期:2017-10-01 00:00:00
abstract::The functional organization of the human brain consists of a high degree of connectivity between interhemispheric homologous regions. The degree of homotopic organization is known to vary across the cortex and homotopic connectivity is high in regions that share cross-hemisphere structural connections or are activated...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23214
更新日期:2016-08-01 00:00:00