Abstract:
:The concept of brain maintenance refers to the preservation of brain integrity in older age, while cognitive reserve refers to the capacity to maintain cognition in the presence of neurodegeneration or aging-related brain changes. While both mechanisms are thought to contribute to individual differences in cognitive function among older adults, there is currently no "gold standard" for measuring these constructs. Using machine-learning methods, we estimated brain and cognitive age based on deviations from normative aging patterns in the Whitehall II MRI substudy cohort (N = 537, age range = 60.34-82.76), and tested the degree of correspondence between these constructs, as well as their associations with premorbid IQ, education, and lifestyle trajectories. In line with established literature highlighting IQ as a proxy for cognitive reserve, higher premorbid IQ was linked to lower cognitive age independent of brain age. No strong evidence was found for associations between brain or cognitive age and lifestyle trajectories from midlife to late life based on latent class growth analyses. However, post hoc analyses revealed a relationship between cumulative lifestyle measures and brain age independent of cognitive age. In conclusion, we present a novel approach to characterizing brain and cognitive maintenance in aging, which may be useful for future studies seeking to identify factors that contribute to brain preservation and cognitive reserve mechanisms in older age.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Anatürk M,Kaufmann T,Cole JH,Suri S,Griffanti L,Zsoldos E,Filippini N,Singh-Manoux A,Kivimäki M,Westlye LT,Ebmeier KP,de Lange AGdoi
10.1002/hbm.25316subject
Has Abstractpub_date
2020-12-14 00:00:00eissn
1065-9471issn
1097-0193pub_type
杂志文章abstract::Mirror neurons, originally described in the monkey premotor area F5, are embedded in a frontoparietal network for action execution and observation. A similar Mirror Neuron System (MNS) exists in humans, including precentral gyrus, inferior parietal lobule, and superior temporal sulcus. Controversial is the inclusion o...
journal_title:Human brain mapping
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journal_title:Human brain mapping
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journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
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journal_title:Human brain mapping
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journal_title:Human brain mapping
pub_type: 杂志文章,评审
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journal_title:Human brain mapping
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journal_title:Human brain mapping
pub_type: 杂志文章,评审
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更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
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pub_type: 杂志文章
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