From simultaneous to synergistic MR-PET brain imaging: A review of hybrid MR-PET imaging methodologies.

Abstract:

:Simultaneous Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) scanning is a recent major development in biomedical imaging. The full integration of the PET detector ring and electronics within the MR system has been a technologically challenging design to develop but provides capacity for simultaneous imaging and the potential for new diagnostic and research capability. This article reviews state-of-the-art MR-PET hardware and software, and discusses future developments focusing on neuroimaging methodologies for MR-PET scanning. We particularly focus on the methodologies that lead to an improved synergy between MRI and PET, including optimal data acquisition, PET attenuation and motion correction, and joint image reconstruction and processing methods based on the underlying complementary and mutual information. We further review the current and potential future applications of simultaneous MR-PET in both systems neuroscience and clinical neuroimaging research. We demonstrate a simultaneous data acquisition protocol to highlight new applications of MR-PET neuroimaging research studies.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Chen Z,Jamadar SD,Li S,Sforazzini F,Baran J,Ferris N,Shah NJ,Egan GF

doi

10.1002/hbm.24314

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

5126-5144

issue

12

eissn

1065-9471

issn

1097-0193

journal_volume

39

pub_type

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