Abstract:
:Recent studies have shown that resting-state functional networks as studied with fMRI, EEG, and MEG may be so-called small-world networks. We investigated to what extent the characteristic features of small-world networks are genetically determined. To represent functional connectivity between brain areas, we measured resting EEG in 574 twins and their siblings and calculated the synchronization likelihood between each pair of electrodes. We applied a threshold to obtain a binary graph from which we calculated the clustering coefficient C (describing local interconnectedness) and average path length L (describing global interconnectedness) for each individual. Modeling of MZ and DZ twin and sibling resemblance indicated that across various frequency bands 46-89% of the individual differences in C and 37-62% of the individual differences in L are heritable. It is asserted that C, L, and a small-world organization are viable markers of genetic differences in brain organization.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Smit DJ,Stam CJ,Posthuma D,Boomsma DI,de Geus EJdoi
10.1002/hbm.20468subject
Has Abstractpub_date
2008-12-01 00:00:00pages
1368-78issue
12eissn
1065-9471issn
1097-0193journal_volume
29pub_type
杂志文章abstract::Catechol-O-methyltransferase (COMT), located on chromosome 22q11.2, encodes an enzyme critical for dopamine flux in the prefrontal cortex. Genetic variants of COMT have been suggested to functionally manipulate prefrontal morphology and function in healthy adults. This study aims to investigate modulative roles of ind...
journal_title:Human brain mapping
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pub_type: 杂志文章,多中心研究
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更新日期:2015-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/hbm.22258
更新日期:2014-04-01 00:00:00
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更新日期:2009-11-01 00:00:00
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