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Mapping reliability in multicenter MRI: voxel-based morphometry and cortical thickness.

Abstract：

:Multicenter structural MRI studies can have greater statistical power than single-center studies. However, across-center differences in contrast sensitivity, spatial uniformity, etc., may lead to tissue classification or image registration differences that could reduce or wholly offset the enhanced statistical power of multicenter data. Prior work has validated volumetric multicenter MRI, but robust methods for assessing reliability and power of multisite analyses with voxel-based morphometry (VBM) and cortical thickness measurement (CORT) are not yet available. We developed quantitative methods to investigate the reproducibility of VBM and CORT to detect group differences and estimate heritability when MRI scans from different scanners running different acquisition protocols in a multicenter setup are included. The method produces brain maps displaying information such as lowest detectable effect size (or heritability) and effective number of subjects in the multicenter study. We applied the method to a five-site multicenter calibration study using scanners from four different manufacturers, running different acquisition protocols. The reliability maps showed an overall good comparability between the sites, providing a reasonable gain in sensitivity in most parts of the brain. In large parts of the cerebrum and cortex scan pooling improved heritability estimates, with "effective-N" values upto the theoretical maximum. For some areas, "optimal-pool" maps indicated that leaving out a site would give better results. The reliability maps also reveal which brain regions are in any case difficult to measure reliably (e.g., around the thalamus). These tools will facilitate the design and analysis of multisite VBM and CORT studies for detecting group differences and estimating heritability.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Schnack HG,van Haren NE,Brouwer RM,van Baal GC,Picchioni M,Weisbrod M,Sauer H,Cannon TD,Huttunen M,Lepage C,Collins DL,Evans A,Murray RM,Kahn RS,Hulshoff Pol HE

doi

10.1002/hbm.20991

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

1967-82

issue

eissn

1065-9471

issn

1097-0193

journal_volume

pub_type

杂志文章,多中心研究

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Mapping reliability in multicenter MRI: voxel-based morphometry and cortical thickness.