A rat brain MRI template with digital stereotaxic atlas of fine anatomical delineations in paxinos space and its automated application in voxel-wise analysis.

Abstract:

:This study constructs a rat brain T2 -weighted magnetic resonance imaging template including olfactory bulb and a compatible digital atlas. The atlas contains 624 carefully delineated brain structures based on the newest (2005) edition of rat brain atlas by Paxinos and Watson. An automated procedure, as an SPM toolbox, was introduced for spatially normalizing individual rat brains, conducting statistical analysis and visually localizing the results in the Atlas coordinate space. The brain template/atlas and the procedure were evaluated using functional images between rats with the right side middle cerebral artery occlusion (MCAO) and normal controls. The result shows that the brain region with significant signal decline in the MCAO rats was consistent with the occlusion position.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Nie B,Chen K,Zhao S,Liu J,Gu X,Yao Q,Hui J,Zhang Z,Teng G,Zhao C,Shan B

doi

10.1002/hbm.21511

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

1306-18

issue

6

eissn

1065-9471

issn

1097-0193

journal_volume

34

pub_type

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