Abstract:
:Human albinism is characterized by a disturbance of the chiasmatic projection system leading to predominant representation of just one eye in the contralateral hemisphere. Patients show congenital nystagmus without perceiving oscillopsia. The purpose of the present study was to demonstrate the consequences of atypical chiasmatic crossing with monocular visual stimulation using functional magnetic resonance imaging (fMRI). Sixteen patients with albinism and fifteen normally pigmented controls were stimulated with a monocular visual activation paradigm using flickering checkerboards. In patients, we observed contralaterally dominated activation of visual cortices correlating to clinical albinism parameters. This confirms albinism as a continuous range of hypopigmentation disorders. Additionally, albinos showed activation of the superior colliculus and of visual motion areas although the stimulus was stationary. Activation of visual motion areas is due probably to congenital nystagmus without a conscious correlate like oscillopsia.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Schmitz B,Käsmann-Kellner B,Schäfer T,Krick CM,Grön G,Backens M,Reith Wdoi
10.1002/hbm.20046keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
40-52issue
1eissn
1065-9471issn
1097-0193journal_volume
23pub_type
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