Intranetwork and internetwork functional connectivity abnormalities in pediatric multiple sclerosis.

Abstract:

:Active motor functional magnetic resonance imaging (fMRI) studies have shown that pediatric multiple sclerosis (MS) patients have a strictly lateralized pattern of activations and a preserved functional connectivity (FC) within the motor system when compared to age-matched healthy controls. However, it is still not clear whether a preserved FC in pediatric MS is present only in the motor system, or involves other relevant functional system. Resting-state (RS) fMRI is a valuable tool for an unbiased investigation of FC abnormalities of multiple networks. This study explored abnormalities of RS FC within and between large-scale neuronal networks from 44 pediatric MS patients and 27 controls and their correlation with clinical, neuropsychological, and conventional MRI measures. Compared to controls, pediatric MS patients had a decreased FC of several regions of the sensorimotor, secondary visual, default-mode (DMN), executive control, and bilateral working memory (WMN) networks. They also experienced an increased FC in the right medial frontal gyrus of the attention network, which was correlated with T2 lesion volume. Cognitively impaired patients had decreased RS FC of the right precuneus of the left WMN. An increased FC between the sensorimotor network and the DMN, and between the L WMN and the attention network as well as a decreased FC between L WMN and the DMN were also found. A distributed pattern of FC abnormalities within large-scale neuronal networks occurs in pediatric MS patients, contributes to their cognitive status, and is partially driven by focal white matter lesions. Internetwork connectivity is relatively preserved in these patients.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Rocca MA,Valsasina P,Absinta M,Moiola L,Ghezzi A,Veggiotti P,Amato MP,Horsfield MA,Falini A,Comi G,Filippi M

doi

10.1002/hbm.22469

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

4180-92

issue

8

eissn

1065-9471

issn

1097-0193

journal_volume

35

pub_type

杂志文章
  • Understanding the association between psychomotor processing speed and white matter hyperintensity: A comprehensive multi-modality MR imaging study.

    abstract::Cognitive processing speed is crucial for human cognition and declines with aging. White matter hyperintensity (WMH), a common sign of WM vascular damage in the elderly, is closely related to slower psychomotor processing speed. In this study, we investigated the association between WMH and psychomotor speed changes t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24826

    authors: Wang S,Jiaerken Y,Yu X,Shen Z,Luo X,Hong H,Sun J,Xu X,Zhang R,Zhou Y,Lou M,Huang P,Zhang M

    更新日期:2020-02-15 00:00:00

  • Altered prefrontal activity and connectivity predict different cognitive deficits in schizophrenia.

    abstract:BACKGROUND:Cognitive dysfunction is considered a core feature of schizophrenia, and impaired performances in episodic memory (EM) and executive function (EF) tasks are consistently reported in schizophrenia patients. Traditional fMRI and EEG studies have helped identifying brain areas, including the prefrontal cortex (...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22935

    authors: Ferrarelli F,Riedner BA,Peterson MJ,Tononi G

    更新日期:2015-11-01 00:00:00

  • Transcranial magnetic stimulation during PET: reaching and verifying the target site.

    abstract::Transcranial magnetic stimulation (TMS) during positron emission tomography (PET) is a novel technique for in vivo measurements of connectivity and excitability of the human cerebral cortex. Here we describe tools that allow investigators to position the stimulating coil over a target region and to verify the actual p...

    journal_title:Human brain mapping

    pub_type: 杂志文章,评审

    doi:

    authors: Paus T,Wolforth M

    更新日期:1998-01-01 00:00:00

  • Characterizing hippocampal dynamics with MEG: A systematic review and evidence-based guidelines.

    abstract::The hippocampus, a hub of activity for a variety of important cognitive processes, is a target of increasing interest for researchers and clinicians. Magnetoencephalography (MEG) is an attractive technique for imaging spectro-temporal aspects of function, for example, neural oscillations and network timing, especially...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24445

    authors: Ruzich E,Crespo-García M,Dalal SS,Schneiderman JF

    更新日期:2019-03-01 00:00:00

  • Cognitive and default-mode resting state networks: do male and female brains "rest" differently?

    abstract::Variability in human behavior related to sex is supported by neuroimaging studies showing differences in brain activation patterns during cognitive task performance. An emerging field is examining the human connectome, including networks of brain regions that are not only temporally-correlated during different task co...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20968

    authors: Weissman-Fogel I,Moayedi M,Taylor KS,Pope G,Davis KD

    更新日期:2010-11-01 00:00:00

  • Early changes in white matter pathways of the sensorimotor cortex in premanifest Huntington's disease.

    abstract:OBJECTIVES:To investigate the function-structure relationship of white matter within different stages of Huntington's disease (HD) using diffusion tensor imaging (DTI). EXPERIMENTAL DESIGN:From the TRACK-HD study, an early stage HD group and a premanifest gene carrier group (PMGC) were age-matched to two healthy contr...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21205

    authors: Dumas EM,van den Bogaard SJ,Ruber ME,Reilman RR,Stout JC,Craufurd D,Hicks SL,Kennard C,Tabrizi SJ,van Buchem MA,van der Grond J,Roos RA

    更新日期:2012-01-01 00:00:00

  • Effects of change in FreeSurfer version on classification accuracy of patients with Alzheimer's disease and mild cognitive impairment.

    abstract::Studies have found non-negligible differences in cortical thickness estimates across versions of software that are used for processing and quantifying MRI-based cortical measurements, and issues have arisen regarding these differences, as obtained estimates could potentially affect the validity of the results. However...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23139

    authors: Chepkoech JL,Walhovd KB,Grydeland H,Fjell AM,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2016-05-01 00:00:00

  • Functional MRI assessment of orofacial articulators: neural correlates of lip, jaw, larynx, and tongue movements.

    abstract::Compared with complex coordinated orofacial actions, few neuroimaging studies have attempted to determine the shared and distinct neural substrates of supralaryngeal and laryngeal articulatory movements when performed independently. To determine cortical and subcortical regions associated with supralaryngeal motor con...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21363

    authors: Grabski K,Lamalle L,Vilain C,Schwartz JL,Vallée N,Tropres I,Baciu M,Le Bas JF,Sato M

    更新日期:2012-10-01 00:00:00

  • Fast robust subject-independent magnetoencephalographic source localization using an artificial neural network.

    abstract::We describe a system that localizes a single dipole to reasonable accuracy from noisy magnetoencephalographic (MEG) measurements in real time. At its core is a multilayer perceptron (MLP) trained to map sensor signals and head position to dipole location. Including head position overcomes the previous need to retrain ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20068

    authors: Jun SC,Pearlmutter BA

    更新日期:2005-01-01 00:00:00

  • Converging function, structure, and behavioural features of emotion regulation in very preterm children.

    abstract::Children born very preterm (VPT; <32 weeks' gestational age) are at high risk for emotional regulation and social communication impairments. However, the underlying neurobiological correlates of these difficulties remain poorly understood. Using a multimodal approach, including both magnetoencephalographic and structu...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24604

    authors: Urbain C,Sato J,Hammill C,Duerden EG,Taylor MJ

    更新日期:2019-08-01 00:00:00

  • Variability of fMRI-response patterns at different spatial observation scales.

    abstract::Functional organization units of the cerebral cortex exist over a wide range of spatial scales, from local circuits to entire cortical areas. In the last decades, scale-space representations of neuroimaging data suited to probe the multi-scale nature of cortical functional organization have been introduced and methodo...

    journal_title:Human brain mapping

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/hbm.21274

    authors: Ball T,Breckel TP,Mutschler I,Aertsen A,Schulze-Bonhage A,Hennig J,Speck O

    更新日期:2012-05-01 00:00:00

  • Detecting bilateral abnormalities with voxel-based morphometry.

    abstract::In this article we describe a new method, using SPM99, that searches explicitly for bilateral structural abnormalities. Children with bilateral pathology have a poorer prognosis than children with unilateral damage. After brain injury or disease in childhood, it is thought that rescue of function is only possible if t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:

    authors: Salmond CH,Ashburner J,Vargha-Khadem F,Gadian DG,Friston KJ

    更新日期:2000-11-01 00:00:00

  • Functional integrity in children with anoxic brain injury from drowning.

    abstract::Drowning is a leading cause of accidental injury and death in young children. Anoxic brain injury (ABI) is a common consequence of drowning and can cause severe neurological morbidity in survivors. Assessment of functional status and prognostication in drowning victims can be extremely challenging, both acutely and ch...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23745

    authors: Ishaque M,Manning JH,Woolsey MD,Franklin CG,Tullis EW,Beckmann CF,Fox PT

    更新日期:2017-10-01 00:00:00

  • Right-hemispheric processing of non-linguistic word features: implications for mapping language recovery after stroke.

    abstract::Verbal stimuli often induce right-hemispheric activation in patients with aphasia after left-hemispheric stroke. This right-hemispheric activation is commonly attributed to functional reorganization within the language system. Yet previous evidence suggests that functional activation in right-hemispheric homologues of...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21512

    authors: Baumgaertner A,Hartwigsen G,Roman Siebner H

    更新日期:2013-06-01 00:00:00

  • Alterations in functional activation in euthymic bipolar disorder and schizophrenia during a working memory task.

    abstract::Dysfunctions in prefrontal cortical networks are thought to underlie working memory (WM) impairments consistently observed in both subjects with bipolar disorder and schizophrenia. It remains unclear, however, whether patterns of WM-related hemodynamic responses are similar in bipolar and schizophrenia subjects compar...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20820

    authors: Hamilton LS,Altshuler LL,Townsend J,Bookheimer SY,Phillips OR,Fischer J,Woods RP,Mazziotta JC,Toga AW,Nuechterlein KH,Narr KL

    更新日期:2009-12-01 00:00:00

  • Methodological issues relating to in vivo cortical myelography using MRI.

    abstract::The relationship between neocortical structure and function is a key area of research in neuroscience. Most studies of neural function, whether using neurophysiology or neuroimaging methods, are interpreted with relation to the underlying cortical myelo- and cytoarchitecture. For functional neuroimaging studies this o...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20162

    authors: Clare S,Bridge H

    更新日期:2005-12-01 00:00:00

  • A technical review of canonical correlation analysis for neuroscience applications.

    abstract::Collecting comprehensive data sets of the same subject has become a standard in neuroscience research and uncovering multivariate relationships among collected data sets have gained significant attentions in recent years. Canonical correlation analysis (CCA) is one of the powerful multivariate tools to jointly investi...

    journal_title:Human brain mapping

    pub_type: 杂志文章,评审

    doi:10.1002/hbm.25090

    authors: Zhuang X,Yang Z,Cordes D

    更新日期:2020-09-01 00:00:00

  • Quantitative tract-based white matter heritability in 1- and 2-year-old twins.

    abstract::White matter (WM) microstructure, as determined by diffusion tensor imaging (DTI), is increasingly recognized as an important determinant of cognitive function and is also altered in neuropsychiatric disorders. Little is known about genetic and environmental influences on WM microstructure, especially in early childho...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24436

    authors: Lee SJ,Zhang J,Neale MC,Styner M,Zhu H,Gilmore JH

    更新日期:2019-03-01 00:00:00

  • Emotion and personal space: Neural correlates of approach-avoidance tendencies to different facial expressions as a function of coldhearted psychopathic traits.

    abstract::In social interactions, humans are expected to regulate interpersonal distance in response to the emotion displayed by others. Yet, the neural mechanisms implicated in approach-avoidance tendencies to distinct emotional expressions have not been fully described. Here, we investigated the neural systems implicated in r...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23467

    authors: Vieira JB,Tavares TP,Marsh AA,Mitchell DG

    更新日期:2017-03-01 00:00:00

  • Corticospinal tract diffusion properties and robotic visually guided reaching in children with hemiparetic cerebral palsy.

    abstract::Perinatal stroke is the leading cause of hemiparetic cerebral palsy (CP), resulting in life-long disability. In this study, we examined the relationship between robotic upper extremity motor impairment and corticospinal tract (CST) diffusion properties. Thirty-three children with unilateral perinatal ischemic stroke (...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23904

    authors: Kuczynski AM,Dukelow SP,Hodge JA,Carlson HL,Lebel C,Semrau JA,Kirton A

    更新日期:2018-03-01 00:00:00

  • Dynamic functional connectivity shapes individual differences in associative learning.

    abstract::Current neuroscientific research has shown that the brain reconfigures its functional interactions at multiple timescales. Here, we sought to link transient changes in functional brain networks to individual differences in behavioral and cognitive performance by using an active learning paradigm. Participants learned ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23285

    authors: Fatima Z,Kovacevic N,Misic B,McIntosh AR

    更新日期:2016-11-01 00:00:00

  • Optimization of retinotopy constrained source estimation constrained by prior.

    abstract::Studying how the timing and amplitude of visual evoked responses (VERs) vary between visual areas is important for understanding visual processing but is complicated by difficulties in reliably estimating VERs in individual visual areas using noninvasive brain measurements. Retinotopy constrained source estimation (RC...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22293

    authors: Hagler DJ Jr

    更新日期:2014-05-01 00:00:00

  • Evolution of deep gray matter volume across the human lifespan.

    abstract::Magnetic resonance imaging of subcortical gray matter structures, which mediate behavior, cognition and the pathophysiology of several diseases, is crucial for establishing typical maturation patterns across the human lifespan. This single site study examines T1-weighted MPRAGE images of 3 healthy cohorts: (i) a cross...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23604

    authors: Narvacan K,Treit S,Camicioli R,Martin W,Beaulieu C

    更新日期:2017-08-01 00:00:00

  • 3D tract-specific local and global analysis of white matter integrity in Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by progressive decline in memory and other aspects of cognitive function. Diffusion-weighted imaging (DWI) offers a non-invasive approach to delineate the effects of AD on white matter (WM) integrity. Previous studies calculated either some ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23448

    authors: Jin Y,Huang C,Daianu M,Zhan L,Dennis EL,Reid RI,Jack CR Jr,Zhu H,Thompson PM,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2017-03-01 00:00:00

  • Multimodal fusion of structural and functional brain imaging in depression using linked independent component analysis.

    abstract::Previous structural and functional neuroimaging studies have implicated distributed brain regions and networks in depression. However, there are no robust imaging biomarkers that are specific to depression, which may be due to clinical heterogeneity and neurobiological complexity. A dimensional approach and fusion of ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24802

    authors: Maglanoc LA,Kaufmann T,Jonassen R,Hilland E,Beck D,Landrø NI,Westlye LT

    更新日期:2020-01-01 00:00:00

  • Multimodal imaging reveals a complex pattern of dysfunction in corticolimbic pathways in major depressive disorder.

    abstract::Major depressive disorder (MDD) is highly prevalent and associated with considerable morbidity, yet its pathophysiology remains only partially understood. While numerous studies have investigated the neurobiological correlates of MDD, most have used only a single neuroimaging modality. In particular, diffusion tensor ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24679

    authors: Nugent AC,Farmer C,Evans JW,Snider SL,Banerjee D,Zarate CA Jr

    更新日期:2019-09-01 00:00:00

  • Opposing patterns of neuronal variability in the sensorimotor network mediate cyclothymic and depressive temperaments.

    abstract::Affective temperaments have been described since the early 20th century and may play a central role in psychiatric illnesses, such as bipolar disorder (BD). However, the neuronal basis of temperament is still unclear. We investigated the relationship of temperament with neuronal variability in the resting state signal...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24453

    authors: Conio B,Magioncalda P,Martino M,Tumati S,Capobianco L,Escelsior A,Adavastro G,Russo D,Amore M,Inglese M,Northoff G

    更新日期:2019-03-01 00:00:00

  • Preferential encoding of movement amplitude and speed in the primary motor cortex and cerebellum.

    abstract::Voluntary movements require control of multiple kinematic parameters, a task carried out by a distributed brain architecture. However, it remains unclear whether regions along the motor system encode single, or rather a mixture of, kinematic parameters during action execution. Here, rapid event-related functional magn...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23802

    authors: Stark-Inbar A,Dayan E

    更新日期:2017-12-01 00:00:00

  • Brain potentials distinguish new and studied objects during working memory.

    abstract::We investigated brain responses to matching versus nonmatching objects in working memory (WM) with a modified delayed match-to-sample task using event-related potentials (ERPs). In addition, ERP correlates of new items (new matches/new nonmatches) and previously studied items (studied matches/studied nonmatches) were ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20409

    authors: Guo C,Lawson AL,Zhang Q,Jiang Y

    更新日期:2008-04-01 00:00:00

  • Tuning-in to the beat: Aesthetic appreciation of musical rhythms correlates with a premotor activity boost.

    abstract::Listening to music can induce us to tune in to its beat. Previous neuroimaging studies have shown that the motor system becomes involved in perceptual rhythm and timing tasks in general, as well as during preference-related responses to music. However, the role of preferred rhythm and, in particular, of preferred beat...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20844

    authors: Kornysheva K,von Cramon DY,Jacobsen T,Schubotz RI

    更新日期:2010-01-01 00:00:00