Altered prefrontal activity and connectivity predict different cognitive deficits in schizophrenia.

Abstract:

BACKGROUND:Cognitive dysfunction is considered a core feature of schizophrenia, and impaired performances in episodic memory (EM) and executive function (EF) tasks are consistently reported in schizophrenia patients. Traditional fMRI and EEG studies have helped identifying brain areas, including the prefrontal cortex (PFC), involved in these tasks. However, it is unclear whether intrinsic defects in prefrontal function per se contribute to poor performance in schizophrenia, given the presence of confounds like reduced motivation and psychotic symptoms. TMS/hd-EEG measurements are obtained without cognitive effort, and can be calculated in any cortical area. METHODS:We performed TMS/hd-EEG recordings in parietal, motor, premotor, and PFC in healthy individuals (N=20) and schizophrenia patients (N=20). Source modeling of TMS-evoked responses was performed, and measures of cortical activity (significant current density, SCD) and connectivity (significant current scattering, SCS) were computed. Patients with schizophrenia also performed Penn Word memory delayed (CPWd) and Penn Conditional Exclusion Test (PCET). CPWd evaluates EM and involves primarily PFC, whereas PCET reflects EF and implicates PFC with other brain regions. FINDINGS:We found no difference in SCD and SCS after TMS of parietal/motor cortices, whereas those parameters were reduced in premotor/prefrontal areas in schizophrenia patients. In PFC, where these measures were most defective, SCD was negatively correlated with performance in CPWd whereas higher SCS values were associated with more errors in PCET. CONCLUSION:These findings indicate that schizophrenia patients have intrinsic defects in both activity and connectivity of PFC, and that these defects are specifically associated with impairments in cognitive abilities.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Ferrarelli F,Riedner BA,Peterson MJ,Tononi G

doi

10.1002/hbm.22935

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

4539-52

issue

11

eissn

1065-9471

issn

1097-0193

journal_volume

36

pub_type

杂志文章
  • Independent component analysis of DTI reveals multivariate microstructural correlations of white matter in the human brain.

    abstract::It has recently been demonstrated that specific patterns of correlation exist in diffusion tensor imaging (DTI) parameters across white matter tracts in the normal human brain. These microstructural correlations are thought to reflect phylogenetic and functional similarities between different axonal fiber pathways. Ho...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21292

    authors: Li YO,Yang FG,Nguyen CT,Cooper SR,LaHue SC,Venugopal S,Mukherjee P

    更新日期:2012-06-01 00:00:00

  • Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis.

    abstract::Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deforma...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22214

    authors: Younes L,Ratnanather JT,Brown T,Aylward E,Nopoulos P,Johnson H,Magnotta VA,Paulsen JS,Margolis RL,Albin RL,Miller MI,Ross CA,PREDICT-HD Investigators and Coordinators of the Huntington Study Group.

    更新日期:2014-03-01 00:00:00

  • Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning.

    abstract::The goal of this study was to document current clinical practice and report patient outcomes in presurgical language functional MRI (fMRI) for epilepsy surgery. Epilepsy surgical programs worldwide were surveyed as to the utility, implementation, and efficacy of language fMRI in the clinic; 82 programs responded. Resp...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24039

    authors: Benjamin CFA,Li AX,Blumenfeld H,Constable RT,Alkawadri R,Bickel S,Helmstaedter C,Meletti S,Bronen R,Warfield SK,Peters JM,Reutens D,Połczyńska M,Spencer DD,Hirsch LJ

    更新日期:2018-07-01 00:00:00

  • Tuning-in to the beat: Aesthetic appreciation of musical rhythms correlates with a premotor activity boost.

    abstract::Listening to music can induce us to tune in to its beat. Previous neuroimaging studies have shown that the motor system becomes involved in perceptual rhythm and timing tasks in general, as well as during preference-related responses to music. However, the role of preferred rhythm and, in particular, of preferred beat...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20844

    authors: Kornysheva K,von Cramon DY,Jacobsen T,Schubotz RI

    更新日期:2010-01-01 00:00:00

  • The human mirror neuron system in a population with deficient self-awareness: an fMRI study in alexithymia.

    abstract::The mirror neuron system (MNS) is considered crucial for human imitation and language learning and provides the basis for the development of empathy and mentalizing. Alexithymia (ALEX), which refers to deficiencies in the self-awareness of emotional states, has been reported to be associated with poor ability in vario...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20653

    authors: Moriguchi Y,Ohnishi T,Decety J,Hirakata M,Maeda M,Matsuda H,Komaki G

    更新日期:2009-07-01 00:00:00

  • Regional hippocampal vulnerability in early multiple sclerosis: Dynamic pathological spreading from dentate gyrus to CA1.

    abstract:BACKGROUND:Whether hippocampal subfields are differentially vulnerable at the earliest stages of multiple sclerosis (MS) and how this impacts memory performance is a current topic of debate. METHOD:We prospectively included 56 persons with clinically isolated syndrome (CIS) suggestive of MS in a 1-year longitudinal st...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23970

    authors: Planche V,Koubiyr I,Romero JE,Manjon JV,Coupé P,Deloire M,Dousset V,Brochet B,Ruet A,Tourdias T

    更新日期:2018-04-01 00:00:00

  • The right VLPFC and downregulation of social pain: A TMS study.

    abstract::Previous studies have demonstrated that the right ventrolateral prefrontal cortex (RVLPFC) is crucially involved in downregulating physical and social pain. However, it remains unclear whether the RVLPFC is more specific to either physical or social pain. The present study compares the role of RVLPFC in emotion regula...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24881

    authors: He Z,Zhao J,Shen J,Muhlert N,Elliott R,Zhang D

    更新日期:2020-04-01 00:00:00

  • 3D tract-specific local and global analysis of white matter integrity in Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by progressive decline in memory and other aspects of cognitive function. Diffusion-weighted imaging (DWI) offers a non-invasive approach to delineate the effects of AD on white matter (WM) integrity. Previous studies calculated either some ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23448

    authors: Jin Y,Huang C,Daianu M,Zhan L,Dennis EL,Reid RI,Jack CR Jr,Zhu H,Thompson PM,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2017-03-01 00:00:00

  • The vomeronasal organ is not involved in the perception of endogenous odors.

    abstract::Chemosensory-based communication is a vital signaling tool in most species, and evidence has recently emerged in support of the notion that humans also use social chemosignals (so-called pheromones) to communicate. An ongoing controversy does exist, however, concerning the receptor organ through which these chemicals ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21035

    authors: Frasnelli J,Lundström JN,Boyle JA,Katsarkas A,Jones-Gotman M

    更新日期:2011-03-01 00:00:00

  • Reduced striato-cortical and inhibitory transcallosal connectivity in the motor circuit of Huntington's disease patients.

    abstract::Huntington's disease (HD) is a neurodegenerative disorder which is primarily associated with striatal degeneration. However, the alterations in connectivity of this structure in HD have been underinvestigated. In this study, we analyzed the functional and structural connectivity of the left putamen, while participants...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23813

    authors: Garcia-Gorro C,de Diego-Balaguer R,Martínez-Horta S,Pérez-Pérez J,Kulisevsky J,Rodríguez-Dechicha N,Vaquer I,Subira S,Calopa M,Muñoz E,Santacruz P,Ruiz-Idiago J,Mareca C,Caballol N,Camara E

    更新日期:2018-01-01 00:00:00

  • Spontaneous blood oxygenation level-dependent fMRI signal is modulated by behavioral state and correlates with evoked response in sensorimotor cortex: a 7.0-T fMRI study.

    abstract::Synchrony measurements of spontaneous low-frequency blood oxygenation level-dependent (BOLD) fluctuations are increasingly being used to investigate spatial regions of functional connectivity. Although information regarding BOLD-BOLD synchrony between different regions is frequently reported, the relationship between ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21228

    authors: Donahue MJ,Hoogduin H,Smith SM,Siero JC,Chappell M,Petridou N,Jezzard P,Luijten PR,Hendrikse J

    更新日期:2012-03-01 00:00:00

  • Tract-based magnetic resonance spectroscopy of the cingulum bundles at 7 T.

    abstract::The cingulum bundle is a white matter fiber bundle in the human brain that is believed to be implicated in various neurological and psychiatric diseases. Subtle disease-related differences in metabolite concentrations in the cingulum tracts that may underlie these diseases may be detected using MR spectroscopic inform...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21302

    authors: Mandl RC,van den Heuvel MP,Klomp DW,Boer VO,Siero JC,Luijten PR,Hulshoff Pol HE

    更新日期:2012-07-01 00:00:00

  • Hemispheric specialization during mental imagery of brisk walking.

    abstract:OBJECTIVES:Brisk walking, a sensitive test to evaluate gait capacity in normal and pathological aging such as parkinsonism, is used as an alternative to classical fitness program for motor rehabilitation and may help to decrease the risk of cognitive deterioration observed with aging. In this study, we aimed to identif...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21255

    authors: Crémers J,Dessoullières A,Garraux G

    更新日期:2012-04-01 00:00:00

  • Connectivity patterns during music listening: Evidence for action-based processing in musicians.

    abstract::Musical expertise is visible both in the morphology and functionality of the brain. Recent research indicates that functional integration between multi-sensory, somato-motor, default-mode (DMN), and salience (SN) networks of the brain differentiates musicians from non-musicians during resting state. Here, we aimed at ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23565

    authors: Alluri V,Toiviainen P,Burunat I,Kliuchko M,Vuust P,Brattico E

    更新日期:2017-06-01 00:00:00

  • Wavelet-based regularity analysis reveals recurrent spatiotemporal behavior in resting-state fMRI.

    abstract::One of the major findings from multimodal neuroimaging studies in the past decade is that the human brain is anatomically and functionally organized into large-scale networks. In resting state fMRI (rs-fMRI), spatial patterns emerge when temporal correlations between various brain regions are tallied, evidencing netwo...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22865

    authors: Smith RX,Jann K,Ances B,Wang DJ

    更新日期:2015-09-01 00:00:00

  • Noninvasive optical imaging in the visual cortex in young infants.

    abstract::During the developmental stage, the brain undergoes anatomic, functional, and metabolic changes necessary to support the complex adaptive behavior of a mature individual. Estimation of developmental changes occurring in different regions of the brain would provide a means of relating various behavioral phenomena to ma...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20020

    authors: Kusaka T,Kawada K,Okubo K,Nagano K,Namba M,Okada H,Imai T,Isobe K,Itoh S

    更新日期:2004-06-01 00:00:00

  • Effect of baseline cannabis use and working-memory network function on changes in cannabis use in heavy cannabis users: a prospective fMRI study.

    abstract::Theoretical models of addiction suggest that a substance use disorder represents an imbalance between hypersensitive motivational processes and deficient regulatory executive functions. Working-memory (a central executive function) may be a powerful predictor of the course of drug use and drug-related problems. Goal o...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22342

    authors: Cousijn J,Wiers RW,Ridderinkhof KR,van den Brink W,Veltman DJ,Goudriaan AE

    更新日期:2014-05-01 00:00:00

  • Brain structural correlates of irritability: Findings in a large healthy cohort.

    abstract::Irritability and nonviolent aggression are common behavioral features across the population, yet there is limited neurobiological research into subclinical phenotypes representing the lower edge of a symptom continuum ranging from slight irritability to criminal violence. We studied brain structural correlates of irri...

    journal_title:Human brain mapping

    pub_type: 杂志文章,多中心研究

    doi:10.1002/hbm.23824

    authors: Besteher B,Squarcina L,Spalthoff R,Bellani M,Gaser C,Brambilla P,Nenadić I

    更新日期:2017-12-01 00:00:00

  • I lie, why don't you: Neural mechanisms of individual differences in self-serving lying.

    abstract::People tend to lie in varying degrees. To advance our understanding of the underlying neural mechanisms of this heterogeneity, we investigated individual differences in self-serving lying. We performed a functional magnetic resonance imaging study in 37 participants and introduced a color-reporting game where lying ab...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24432

    authors: Yin L,Weber B

    更新日期:2019-03-01 00:00:00

  • Neural specialization of phonological and semantic processing in young children.

    abstract::This study aimed to examine early specialization of brain regions for phonological and semantic processing of spoken language in young children. Thirty-five typically developing children aged from 5 to 6 years performed auditory phonological (same sound judgment) and semantic (related meaning judgment) word-level task...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24274

    authors: Weiss Y,Cweigenberg HG,Booth JR

    更新日期:2018-11-01 00:00:00

  • 5-HTTLPR moderates the association between interdependence and brain responses to mortality threats.

    abstract::While behavioral research suggests an association between cultural worldview and decreased anxiety of death, the underlying neurobiological mechanisms remain unclear. Using functional MRI, we investigated whether and how the serotonin transporter promoter polymorphism (5-HTTLPR), which has been associated with mental ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23819

    authors: Luo S,Yu D,Han S

    更新日期:2017-12-01 00:00:00

  • Learned control of inter-hemispheric connectivity: Effects on bimanual motor performance.

    abstract::Bimanual movements involve the interactions between both primary motor cortices. These interactions are assumed to involve phase-locked oscillatory brain activity referred to as inter-hemispheric functional coupling. So far, inter-hemispheric functional coupling has been investigated as a function of motor performance...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23663

    authors: Kajal DS,Braun C,Mellinger J,Sacchet MD,Ruiz S,Fetz E,Birbaumer N,Sitaram R

    更新日期:2017-09-01 00:00:00

  • Brain systems involved in arithmetic with positive versus negative numbers.

    abstract::Positive number arithmetic is based on combining and separating sets of items, with systematic differences in brain activity in specific regions depending on operation. In contrast, arithmetic with negative numbers involves manipulating abstract values worth less than zero, possibly involving different operation-activ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22201

    authors: Gullick MM,Wolford G

    更新日期:2014-02-01 00:00:00

  • Neural correlates of successful semantic processing during propofol sedation.

    abstract::Sedation has a graded effect on brain responses to auditory stimuli: perceptual processing persists at sedation levels that attenuate more complex processing. We used fMRI in healthy volunteers sedated with propofol to assess changes in neural responses to spoken stimuli. Volunteers were scanned awake, sedated, and du...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22375

    authors: Adapa RM,Davis MH,Stamatakis EA,Absalom AR,Menon DK

    更新日期:2014-07-01 00:00:00

  • Differential patterns of dynamic functional connectivity variability of striato-cortical circuitry in children with benign epilepsy with centrotemporal spikes.

    abstract::Benign epilepsy with centrotemporal spikes (BECTS) is characterized by abnormal (static) functional interactions among cortical and subcortical regions, regardless of the active or chronic epileptic state. However, human brain connectivity is dynamic and associated with ongoing rhythmic activity. The dynamic functiona...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23910

    authors: Li R,Liao W,Yu Y,Chen H,Guo X,Tang YL,Chen H

    更新日期:2018-03-01 00:00:00

  • Mapping reliability in multicenter MRI: voxel-based morphometry and cortical thickness.

    abstract::Multicenter structural MRI studies can have greater statistical power than single-center studies. However, across-center differences in contrast sensitivity, spatial uniformity, etc., may lead to tissue classification or image registration differences that could reduce or wholly offset the enhanced statistical power o...

    journal_title:Human brain mapping

    pub_type: 杂志文章,多中心研究

    doi:10.1002/hbm.20991

    authors: Schnack HG,van Haren NE,Brouwer RM,van Baal GC,Picchioni M,Weisbrod M,Sauer H,Cannon TD,Huttunen M,Lepage C,Collins DL,Evans A,Murray RM,Kahn RS,Hulshoff Pol HE

    更新日期:2010-12-01 00:00:00

  • Linear and nonlinear interrelations show fundamentally distinct network structure in preictal intracranial EEG of epilepsy patients.

    abstract::Resection of the seizure generating tissue can be highly beneficial in patients with drug-resistant epilepsy. However, only about half of all patients undergoing surgery get permanently and completely seizure free. Investigating the dependences between intracranial EEG signals adds a multivariate perspective largely u...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24816

    authors: Müller M,Caporro M,Gast H,Pollo C,Wiest R,Schindler K,Rummel C

    更新日期:2020-02-01 00:00:00

  • Corticospinal tract diffusion properties and robotic visually guided reaching in children with hemiparetic cerebral palsy.

    abstract::Perinatal stroke is the leading cause of hemiparetic cerebral palsy (CP), resulting in life-long disability. In this study, we examined the relationship between robotic upper extremity motor impairment and corticospinal tract (CST) diffusion properties. Thirty-three children with unilateral perinatal ischemic stroke (...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23904

    authors: Kuczynski AM,Dukelow SP,Hodge JA,Carlson HL,Lebel C,Semrau JA,Kirton A

    更新日期:2018-03-01 00:00:00

  • Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates' brains in the first six weeks of life.

    abstract::With the causes of perinatal brain injuries still unclear and the probable role of hemodynamic instability in their etiology, bedside monitoring of neonatal cerebral hemodynamics with standard values as a function of age are needed. In this study, we combined quantitative frequency domain near infrared spectroscopy (F...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20868

    authors: Roche-Labarbe N,Carp SA,Surova A,Patel M,Boas DA,Grant PE,Franceschini MA

    更新日期:2010-03-01 00:00:00

  • Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure.

    abstract::Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed a...

    journal_title:Human brain mapping

    pub_type: 杂志文章,评审

    doi:10.1002/hbm.25029

    authors: Hoogman M,van Rooij D,Klein M,Boedhoe P,Ilioska I,Li T,Patel Y,Postema MC,Zhang-James Y,Anagnostou E,Arango C,Auzias G,Banaschewski T,Bau CHD,Behrmann M,Bellgrove MA,Brandeis D,Brem S,Busatto GF,Calderoni S,Calvo

    更新日期:2020-05-18 00:00:00