Independent component analysis of DTI reveals multivariate microstructural correlations of white matter in the human brain.

Abstract:

:It has recently been demonstrated that specific patterns of correlation exist in diffusion tensor imaging (DTI) parameters across white matter tracts in the normal human brain. These microstructural correlations are thought to reflect phylogenetic and functional similarities between different axonal fiber pathways. However, this earlier work was limited in three major respects: (1) the analysis was restricted to only a dozen selected tracts; (2) the DTI measurements were averaged across whole tracts, whereas metrics such as fractional anisotropy (FA) are known to vary considerably within single tracts; and (3) a univariate measure of correlation was used. In this investigation, we perform an automated multivariate whole-brain voxel-based study of white matter FA correlations using independent component analysis (ICA) of tract-based spatial statistics computed from 3T DTI in 53 healthy adult volunteers. The resulting spatial maps of the independent components show voxels for which the FA values within each map co-vary across individuals. The strongest FA correlations were found in anatomically recognizable tracts and tract segments, either singly or in homologous pairs. Hence, ICA of DTI provides an automated unsupervised decomposition of the normal human brain into multiple separable microstructurally correlated white matter regions, many of which correspond to anatomically familiar classes of white matter pathways. Further research is needed to determine whether whole-brain ICA of DTI represents a novel alternative to tractography for feature extraction in studying the normal microstructure of human white matter as well as the abnormal white matter microstructure found in neurological and psychiatric disorders.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Li YO,Yang FG,Nguyen CT,Cooper SR,LaHue SC,Venugopal S,Mukherjee P

doi

10.1002/hbm.21292

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

1431-51

issue

6

eissn

1065-9471

issn

1097-0193

journal_volume

33

pub_type

杂志文章
  • The functional role of human right hippocampal/parahippocampal theta rhythm in environmental encoding during virtual spatial navigation.

    abstract::Low frequency theta band oscillations (4-8 Hz) are thought to provide a timing mechanism for hippocampal place cell firing and to mediate the formation of spatial memory. In rodents, hippocampal theta has been shown to play an important role in encoding a new environment during spatial navigation, but a similar functi...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23458

    authors: Pu Y,Cornwell BR,Cheyne D,Johnson BW

    更新日期:2017-03-01 00:00:00

  • Brain functional correlates of emotion regulation across adolescence and young adulthood.

    abstract::Few studies have examined the neural correlates of emotion regulation across adolescence and young adulthood. Existing studies of cognitive reappraisal indicate that improvements in regulatory efficiency may develop linearly across this period, in accordance with maturation of prefrontal cortical systems. However, the...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22905

    authors: Stephanou K,Davey CG,Kerestes R,Whittle S,Pujol J,Yücel M,Fornito A,López-Solà M,Harrison BJ

    更新日期:2016-01-01 00:00:00

  • Speed of saccade execution and inhibition associated with fractional anisotropy in distinct fronto-frontal and fronto-striatal white matter pathways.

    abstract::Fast cancellation or switching of action plans is a critical cognitive function. Rapid signal transmission is key for quickly executing and inhibiting responses, and the structural integrity of connections between brain regions plays a crucial role in signal transmission speed. In this study, we used the search-step t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23209

    authors: Thakkar KN,van den Heiligenberg FM,Kahn RS,Neggers SF

    更新日期:2016-08-01 00:00:00

  • Resting-state functional connectivity of the human hypothalamus.

    abstract::The hypothalamus is of enormous importance for multiple bodily functions such as energy homeostasis. Especially, rodent studies have greatly contributed to our understanding how specific hypothalamic subregions integrate peripheral and central signals into the brain to control food intake. In humans, however, the neur...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22607

    authors: Kullmann S,Heni M,Linder K,Zipfel S,Häring HU,Veit R,Fritsche A,Preissl H

    更新日期:2014-12-01 00:00:00

  • Cognitive phenotypes in parkinson's disease differ in terms of brain-network organization and connectivity.

    abstract::Cognitive deficits are common in Parkinson's disease and we suspect that dysfunctions of connected brain regions can be the source of these deficits. The aim of the present study was to investigate changes in whole-brain intrinsic functional connectivity according to differences in cognitive profiles in Parkinson's di...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23474

    authors: Lopes R,Delmaire C,Defebvre L,Moonen AJ,Duits AA,Hofman P,Leentjens AF,Dujardin K

    更新日期:2017-03-01 00:00:00

  • Emerging atypical connectivity networks for processing angry and fearful faces in very preterm born children.

    abstract::Very preterm born (VPT) children are those born before 32/40 weeks' gestational age and comprise 10% of the 15 million babies born prematurely worldwide each year. Due to advancements in neonatal medicine, the survival rate of VPT birth has increased, but few studies have investigated the nonmedical, social-cognitive ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.25088

    authors: Mossad SI,Muscat C,Pang EW,Taylor M

    更新日期:2020-09-01 00:00:00

  • Spatiotemporal characteristics of electrocortical brain activity during mental calculation.

    abstract::Mental calculation is a complex mental procedure involving a frontoparietal network of brain regions. Functional MRI (fMRI) studies have revealed interesting characteristics of these regions, but the precise function of some areas remains elusive. In the present study, we used electrocorticographic (ECoG) recordings t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22593

    authors: Vansteensel MJ,Bleichner MG,Freudenburg ZV,Hermes D,Aarnoutse EJ,Leijten FS,Ferrier CH,Jansma JM,Ramsey NF

    更新日期:2014-12-01 00:00:00

  • Statistical inference in brain graphs using threshold-free network-based statistics.

    abstract::The description of brain networks as graphs where nodes represent different brain regions and edges represent a measure of connectivity between a pair of nodes is an increasingly used approach in neuroimaging research. The development of powerful methods for edge-wise group-level statistical inference in brain graphs ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24007

    authors: Baggio HC,Abos A,Segura B,Campabadal A,Garcia-Diaz A,Uribe C,Compta Y,Marti MJ,Valldeoriola F,Junque C

    更新日期:2018-06-01 00:00:00

  • The role of the superior temporal sulcus and the mirror neuron system in imitation.

    abstract::It has been suggested that in humans the mirror neuron system provides a neural substrate for imitation behaviour, but the relative contributions of different brain regions to the imitation of manual actions is still a matter of debate. To investigate the role of the mirror neuron system in imitation we used fMRI to e...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20938

    authors: Molenberghs P,Brander C,Mattingley JB,Cunnington R

    更新日期:2010-09-01 00:00:00

  • A surface-based technique for mapping homotopic interhemispheric connectivity: Development, characterization, and clinical application.

    abstract::The functional organization of the human brain consists of a high degree of connectivity between interhemispheric homologous regions. The degree of homotopic organization is known to vary across the cortex and homotopic connectivity is high in regions that share cross-hemisphere structural connections or are activated...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23214

    authors: Tobyne SM,Boratyn D,Johnson JA,Greve DN,Mainero C,Klawiter EC

    更新日期:2016-08-01 00:00:00

  • Childhood maltreatment is associated with an automatic negative emotion processing bias in the amygdala.

    abstract:UNLABELLED:Major depression has been repeatedly associated with amygdala hyper-responsiveness to negative (but not positive) facial expressions at early, automatic stages of emotion processing using subliminally presented stimuli. However, it is not clear whether this "limbic bias" is a correlate of depression or repre...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22112

    authors: Dannlowski U,Kugel H,Huber F,Stuhrmann A,Redlich R,Grotegerd D,Dohm K,Sehlmeyer C,Konrad C,Baune BT,Arolt V,Heindel W,Zwitserlood P,Suslow T

    更新日期:2013-11-01 00:00:00

  • Altered functional connectivity of primary visual cortex in early blindness.

    abstract::In early blindness, the primary visual area (PVA) loses the ability to process visual information, and shifts to working on the processing of somatosensory input, auditory input, and some higher-level cognitive functions. It has not yet been investigated whether such functional changes can lead to alterations of the f...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20420

    authors: Yu C,Liu Y,Li J,Zhou Y,Wang K,Tian L,Qin W,Jiang T,Li K

    更新日期:2008-05-01 00:00:00

  • Interhemispheric differences of fMRI responses to visual stimuli in patients with side-fixed migraine aura.

    abstract::Migraine sufferers with aura often report photosensitivity and visual discomfort outside of attacks and many consider bright or flickering light an attack-precipitating factor. The nature of this visual hypersensitivity and its relation to the underlying pathophysiology of the migraine aura is unknown. Using fMRI meas...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22361

    authors: Hougaard A,Amin FM,Hoffmann MB,Rostrup E,Larsson HB,Asghar MS,Larsen VA,Olesen J,Ashina M

    更新日期:2014-06-01 00:00:00

  • From hippocampus to whole-brain: The role of integrative processing in episodic memory retrieval.

    abstract::Multivariate functional connectivity analyses of neuroimaging data have revealed the importance of complex, distributed interactions between disparate yet interdependent brain regions. Recent work has shown that topological properties of functional brain networks are associated with individual and group differences in...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23518

    authors: Geib BR,Stanley ML,Dennis NA,Woldorff MG,Cabeza R

    更新日期:2017-04-01 00:00:00

  • Key functional circuitry altered in schizophrenia involves parietal regions associated with sense of self.

    abstract::There is still no clear consensus as to which of the many functional and structural changes in the brain in schizophrenia are of most importance, although the main focus to date has been on those in the frontal and cingulate cortices. In the present study, we have used a novel holistic approach to identify brain-wide ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22162

    authors: Guo S,Kendrick KM,Yu R,Wang HL,Feng J

    更新日期:2014-01-01 00:00:00

  • Neural substrates differentiating global/local processing of bilateral visual inputs.

    abstract::We investigated neural substrates of global/local processing of bilateral hierarchical stimuli using functional magnetic resonance imaging (fMRI). Subjects were presented with two compound letters that were displayed simultaneously in the left and right visual fields, respectively. In a steady-state, block-design para...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20044

    authors: Han S,Jiang Y,Gu H

    更新日期:2004-08-01 00:00:00

  • Robust Bayesian estimation of the hemodynamic response function in event-related BOLD fMRI using basic physiological information.

    abstract::In BOLD fMRI data analysis, robust and accurate estimation of the Hemodynamic Response Function (HRF) is still under investigation. Parametric methods assume the shape of the HRF to be known and constant throughout the brain, whereas non-parametric methods mostly rely on artificially increasing the signal-to-noise rat...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.10100

    authors: Marrelec G,Benali H,Ciuciu P,Pélégrini-Issac M,Poline JB

    更新日期:2003-05-01 00:00:00

  • Decoding facial expressions based on face-selective and motion-sensitive areas.

    abstract::Humans can easily recognize others' facial expressions. Among the brain substrates that enable this ability, considerable attention has been paid to face-selective areas; in contrast, whether motion-sensitive areas, which clearly exhibit sensitivity to facial movements, are involved in facial expression recognition re...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23578

    authors: Liang Y,Liu B,Xu J,Zhang G,Li X,Wang P,Wang B

    更新日期:2017-06-01 00:00:00

  • Spontaneous blood oxygenation level-dependent fMRI signal is modulated by behavioral state and correlates with evoked response in sensorimotor cortex: a 7.0-T fMRI study.

    abstract::Synchrony measurements of spontaneous low-frequency blood oxygenation level-dependent (BOLD) fluctuations are increasingly being used to investigate spatial regions of functional connectivity. Although information regarding BOLD-BOLD synchrony between different regions is frequently reported, the relationship between ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21228

    authors: Donahue MJ,Hoogduin H,Smith SM,Siero JC,Chappell M,Petridou N,Jezzard P,Luijten PR,Hendrikse J

    更新日期:2012-03-01 00:00:00

  • Broadband neurophysiological abnormalities in the medial prefrontal region of the default-mode network in adults with ADHD.

    abstract::Previous investigations of the default-mode network (DMN) in persons with attention-deficit/hyperactivity disorder (ADHD) have shown reduced functional connectivity between the anterior and posterior aspects. This finding was originally demonstrated in adults with ADHD, then in youth with ADHD, and has been tentativel...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21459

    authors: Wilson TW,Franzen JD,Heinrichs-Graham E,White ML,Knott NL,Wetzel MW

    更新日期:2013-03-01 00:00:00

  • Real-time strategy video game experience and structural connectivity - A diffusion tensor imaging study.

    abstract::Experienced video game players exhibit superior performance in visuospatial cognition when compared to non-players. However, very little is known about the relation between video game experience and structural brain plasticity. To address this issue, a direct comparison of the white matter brain structure in RTS (real...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24208

    authors: Kowalczyk N,Shi F,Magnuski M,Skorko M,Dobrowolski P,Kossowski B,Marchewka A,Bielecki M,Kossut M,Brzezicka A

    更新日期:2018-09-01 00:00:00

  • Quantitative tract-based white matter heritability in 1- and 2-year-old twins.

    abstract::White matter (WM) microstructure, as determined by diffusion tensor imaging (DTI), is increasingly recognized as an important determinant of cognitive function and is also altered in neuropsychiatric disorders. Little is known about genetic and environmental influences on WM microstructure, especially in early childho...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24436

    authors: Lee SJ,Zhang J,Neale MC,Styner M,Zhu H,Gilmore JH

    更新日期:2019-03-01 00:00:00

  • Irony comprehension: social conceptual knowledge and emotional response.

    abstract::Verbal irony conveys various emotional messages, from criticism to humor, that differ from the meaning of the actual words. To understand irony, we need conceptual knowledge of irony in addition to an understanding of context. We investigated the neural mechanism of irony comprehension, focusing on two overlooked issu...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22242

    authors: Akimoto Y,Sugiura M,Yomogida Y,Miyauchi CM,Miyazawa S,Kawashima R

    更新日期:2014-04-01 00:00:00

  • Neural signatures of fairness-related normative decision making in the ultimatum game: a coordinate-based meta-analysis.

    abstract::The willingness to incur personal costs to enforce prosocial norms represents a hallmark of human civilization. Although recent neuroscience studies have used the ultimatum game to understand the neuropsychological mechanisms that underlie the enforcement of fairness norms; however, a precise characterization of the n...

    journal_title:Human brain mapping

    pub_type: 杂志文章,meta分析

    doi:10.1002/hbm.22649

    authors: Feng C,Luo YJ,Krueger F

    更新日期:2015-02-01 00:00:00

  • Neural correlates of successful semantic processing during propofol sedation.

    abstract::Sedation has a graded effect on brain responses to auditory stimuli: perceptual processing persists at sedation levels that attenuate more complex processing. We used fMRI in healthy volunteers sedated with propofol to assess changes in neural responses to spoken stimuli. Volunteers were scanned awake, sedated, and du...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22375

    authors: Adapa RM,Davis MH,Stamatakis EA,Absalom AR,Menon DK

    更新日期:2014-07-01 00:00:00

  • From personal fear to mass panic: The neurological basis of crowd perception.

    abstract::Recent studies have investigated the neural correlates of how we perceive emotions of individuals or a group of individuals using images of individual bodily expressions. However, it is still largely unknown how we perceive the emotion of a dynamic crowd. This fMRI study used realistic videos of a large group of peopl...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22774

    authors: Huis In 't Veld EM,de Gelder B

    更新日期:2015-06-01 00:00:00

  • Temporal stability of functional brain modules associated with human intelligence.

    abstract::Individual differences in general cognitive ability (i.e., intelligence) have been linked to individual variations in the modular organization of functional brain networks. However, these analyses have been limited to static (time-averaged) connectivity, and have not yet addressed whether dynamic changes in the config...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24807

    authors: Hilger K,Fukushima M,Sporns O,Fiebach CJ

    更新日期:2020-02-01 00:00:00

  • Threat as a feature in visual semantic object memory.

    abstract::Threatening stimuli have been found to modulate visual processes related to perception and attention. The present functional magnetic resonance imaging (fMRI) study investigated whether threat modulates visual object recognition of man-made and naturally occurring categories of stimuli. Compared with nonthreatening pi...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22039

    authors: Calley CS,Motes MA,Chiang HS,Buhl V,Spence JS,Abdi H,Anand R,Maguire M,Estevez L,Briggs R,Freeman T,Kraut MA,Hart J Jr

    更新日期:2013-08-01 00:00:00

  • Mapping the structural and functional network architecture of the medial temporal lobe using 7T MRI.

    abstract::Medial temporal lobe (MTL) subregions play integral roles in memory function and are differentially affected in various neurological and psychiatric disorders. The ability to structurally and functionally characterize these subregions may be important to understanding MTL physiology and diagnosing diseases involving t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23887

    authors: Shah P,Bassett DS,Wisse LEM,Detre JA,Stein JM,Yushkevich PA,Shinohara RT,Pluta JB,Valenciano E,Daffner M,Wolk DA,Elliott MA,Litt B,Davis KA,Das SR

    更新日期:2018-02-01 00:00:00

  • Modular preprocessing pipelines can reintroduce artifacts into fMRI data.

    abstract::The preprocessing pipelines typically used in both task and resting-state functional magnetic resonance imaging (rs-fMRI) analysis are modular in nature: They are composed of a number of separate filtering/regression steps, including removal of head motion covariates and band-pass filtering, performed sequentially and...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24528

    authors: Lindquist MA,Geuter S,Wager TD,Caffo BS

    更新日期:2019-06-01 00:00:00