Abstract:
:In BOLD fMRI data analysis, robust and accurate estimation of the Hemodynamic Response Function (HRF) is still under investigation. Parametric methods assume the shape of the HRF to be known and constant throughout the brain, whereas non-parametric methods mostly rely on artificially increasing the signal-to-noise ratio. We extend and develop a previously proposed method that makes use of basic yet relevant temporal information about the underlying physiological process of the brain BOLD response in order to infer the HRF in a Bayesian framework. A general hypothesis test is also proposed, allowing to take advantage of the knowledge gained regarding the HRF to perform activation detection. The performances of the method are then evaluated by simulation. Great improvement is shown compared to the Maximum-Likelihood estimate in terms of estimation error, variance, and bias. Robustness of the estimators with regard to the actual noise structure or level, as well as the stimulus sequence, is also proven. Lastly, fMRI data with an event-related paradigm are analyzed. As suspected, the regions selected from highly discriminating activation maps resulting from the method exhibit a certain inter-regional homogeneity in term of HRF shape, as well as noticeable inter-regional differences.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Marrelec G,Benali H,Ciuciu P,Pélégrini-Issac M,Poline JBdoi
10.1002/hbm.10100keywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
1-17issue
1eissn
1065-9471issn
1097-0193journal_volume
19pub_type
杂志文章abstract::Parkinsonism has heterogeneous nature, showing distinctive patterns of disease progression and prognosis. We aimed to find clusters of parkinsonism based on 18 F-fluoropropyl-carbomethoxyiodophenylnortropane (FP-CIT) PET as a data-driven approach to evaluate heterogenous dopaminergic neurodegeneration patterns. Two di...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25155
更新日期:2020-11-01 00:00:00
abstract::The action observation network (AON) is supposed to play a crucial role when athletes anticipate the effect of others' actions in sports such as tennis. We used functional magnetic resonance imaging to explore whether motor expertise leads to a differential activation pattern within the AON during effect anticipation ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22455
更新日期:2014-08-01 00:00:00
abstract::The results of most neuroimaging studies are reported in volumetric (e.g., MNI152) or surface (e.g., fsaverage) coordinate systems. Accurate mappings between volumetric and surface coordinate systems can facilitate many applications, such as projecting fMRI group analyses from MNI152/Colin27 to fsaverage for visualiza...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24213
更新日期:2018-09-01 00:00:00
abstract::The extent of central nervous system involvement in Kennedy's disease (KD) relative to other motor neuron disease (MND) phenotypes still needs to be clarified. In this study, we investigated cortical and white matter (WM) MRI alterations in 25 patients with KD, compared with 24 healthy subjects, 25 patients with spora...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24583
更新日期:2019-07-01 00:00:00
abstract::Multiple sclerosis (MS) patients present several alterations related to sensing of bodily signals. However, no specific neurocognitive impairment has yet been proposed as a core deficit underlying such symptoms. We aimed to determine whether MS patients present changes in interoception-that is, the monitoring of auton...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24319
更新日期:2018-12-01 00:00:00
abstract::Central brain network connections greatly contribute to overall network efficiency. Here we examined whether small vessel disease (SVD) related white matter alterations in central brain network connections have a greater impact on executive functioning than alterations in non-central brain network connections. Brain n...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23186
更新日期:2016-07-01 00:00:00
abstract::Mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) are common among recent military veterans and involve substantial symptom overlap, making clinical distinction and effective intervention difficult. Emerging evidence of cerebral white matter abnormalities associated with mTBI may provide a b...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22685
更新日期:2015-03-01 00:00:00
abstract::It has previously been demonstrated that there is a negative correlation between the amplitude of the BOLD response and resting γ amino-butyric acid (GABA) concentration in visual cortex. The work here is the first to empirically characterize individual variability in the haemodynamic response functions (HRFs) in resp...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21223
更新日期:2012-02-01 00:00:00
abstract::Estimating the thickness of the cerebral cortex is a key step in many brain imaging studies, revealing valuable information on development or disease progression. In this work, we present a framework for measuring the cortical thickness, based on minimizing line integrals over the probability map of the gray matter in...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20740
更新日期:2009-10-01 00:00:00
abstract::Language processing engages large-scale functional networks in both hemispheres. Although it is widely accepted that left perisylvian regions have a key role in supporting complex grammatical computations, patient data suggest that some aspects of grammatical processing could be supported bilaterally. We investigated ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22696
更新日期:2015-03-01 00:00:00
abstract::Apathy, common in neurological disorders, is defined as disinterest and loss of motivation, with a reduction in self-initiated activity. Research in diseased populations has shown that apathy is associated with variations in the volume of brain regions such as the anterior cingulate and the frontal lobes. The goal of ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22225
更新日期:2014-03-01 00:00:00
abstract::Fetal alcohol spectrum disorders (FASD) are debilitating, with effects of prenatal alcohol exposure persisting into adolescence and adulthood. Complete characterization of FASD is crucial for the development of diagnostic tools and intervention techniques to decrease the high cost to individual families and society of...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22110
更新日期:2013-11-01 00:00:00
abstract::There are an increasing number of neuroimaging studies that allow a better understanding of symptoms, neural correlates and associated conditions of fibromyalgia. However, the results of these studies are difficult to compare, as they include a heterogeneous group of patients, use different stimulation paradigms, task...
journal_title:Human brain mapping
pub_type: 杂志文章,meta分析
doi:10.1002/hbm.23132
更新日期:2016-05-01 00:00:00
abstract::Accumulating evidence suggests that early improvement after two-week antidepressant treatment is predictive of later outcomes of patients with major depressive disorder (MDD); however, whether this early improvement is associated with baseline neural architecture remains largely unknown. Utilizing resting-state functi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22817
更新日期:2015-08-01 00:00:00
abstract::We monitored regional cerebral activity with BOLD fMRI while subjects were presented written sentences differing in their grammatical structure (subject-relative or object-relative center-embedded clauses) and their short-term memory demands (short or long antecedent-gap linkages). A core region of left posterior supe...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.10006
更新日期:2002-02-01 00:00:00
abstract::Benign epilepsy with centrotemporal spikes (BECTS) is characterized by abnormal (static) functional interactions among cortical and subcortical regions, regardless of the active or chronic epileptic state. However, human brain connectivity is dynamic and associated with ongoing rhythmic activity. The dynamic functiona...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23910
更新日期:2018-03-01 00:00:00
abstract::Individual differences in general cognitive ability (i.e., intelligence) have been linked to individual variations in the modular organization of functional brain networks. However, these analyses have been limited to static (time-averaged) connectivity, and have not yet addressed whether dynamic changes in the config...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24807
更新日期:2020-02-01 00:00:00
abstract::Magnetoencephalographic (MEG) investigations of inter-regional amplitude correlations have yielded new insights into the organization and neurophysiology of resting-state networks (RSNs) first identified using fMRI. Inter-regional MEG amplitude correlations in adult RSNs have been shown to be most prominent in alpha a...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22547
更新日期:2014-10-01 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disorder with dysfunction in cortices as well as white matter (WM) tracts. While the changes to WM structure have been extensively investigated in PD, the nature of the functional changes to WM remains unknown. In this study, the regional activity and functional connecti...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24444
更新日期:2019-03-01 00:00:00
abstract::The sudden onset of a face image leads to a prominent face-selective response in human scalp electroencephalographic (EEG) recordings, peaking 170 ms after stimulus onset at occipito-temporal (OT) scalp sites: the N170 (or M170 in magnetoencephalography). According to a widely held view, the main cortical source of th...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24455
更新日期:2019-04-01 00:00:00
abstract::There is still no clear consensus as to which of the many functional and structural changes in the brain in schizophrenia are of most importance, although the main focus to date has been on those in the frontal and cingulate cortices. In the present study, we have used a novel holistic approach to identify brain-wide ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22162
更新日期:2014-01-01 00:00:00
abstract::Degeneration of the corpus callosum (CC) is evident in the pathogenesis of Alzheimer's disease (AD). However, the correlation of microstructural damage in the CC on the cognitive performance of patients with amnestic mild cognitive impairment (aMCI) and AD dementia is undetermined. We enrolled 26 normal controls, 24 p...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22271
更新日期:2014-04-01 00:00:00
abstract::The present study examines the neural substrates for the perception of speech rhythm and intonation. Subjects listened passively to synthesized speech stimuli that contained no semantic and phonological information, in three conditions: (1) continuous speech stimuli with fixed syllable duration and fundamental frequen...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20922
更新日期:2010-07-01 00:00:00
abstract::The recent ability to measure in vivo beta-amyloid (Aβ), a marker of Alzheimer's disease (AD), has led to an increased focus on the significance of Aβ deposition in clinically normal adults. Evidence suggests that healthy adults with elevated cortical Aβ show differences in neural activity associated with memory encod...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22788
更新日期:2015-07-01 00:00:00
abstract::We studied the relationship between muscle activity (electromyography, EMG), force, and brain activity during isometric contractions of the index finger, on a group and individual level. Ten subjects contracted their right or left index finger at 5, 15, 30, 50, and 70% of their maximal force. Subjects received visual ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20388
更新日期:2008-03-01 00:00:00
abstract::In previous work (Penny et al., [2005]: Neuroimage 24:350-362) we have developed a spatially regularised General Linear Model for the analysis of functional magnetic resonance imaging data that allows for the characterisation of regionally specific effects using Posterior Probability Maps (PPMs). In this paper we show...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20327
更新日期:2007-04-01 00:00:00
abstract::The development of language, social interaction, and communicative skills are remarkably different in the child with autism spectrum disorder (ASD). Atypical brain connectivity has frequently been reported in this patient population. However, the interplay between their brain connectivity and language performance rema...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22424
更新日期:2014-08-01 00:00:00
abstract::The processes underlying perceptual decision making are diverse and typically engage a distributed network of brain areas. It is a particular challenge to establish a sensory-to-motor functional hierarchy in such networks. This is because single-cell recordings mainly study the nodes of decision networks in isolation ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23446
更新日期:2017-03-01 00:00:00
abstract::Recent studies have shown that resting-state functional networks as studied with fMRI, EEG, and MEG may be so-called small-world networks. We investigated to what extent the characteristic features of small-world networks are genetically determined. To represent functional connectivity between brain areas, we measured...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20468
更新日期:2008-12-01 00:00:00
abstract::Recent research found lasting increases in personality trait Openness in healthy individuals and patients after administration of the serotonin 2A receptor (5-HT2A R) agonist psilocybin. However, no studies have investigated whether 5-HT2A R availability as imaged using positron emission tomography (PET) is associated...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24511
更新日期:2019-05-01 00:00:00