Unsupervised clustering of dopamine transporter PET imaging discovers heterogeneity of parkinsonism.

abstract：:Musical expertise is visible both in the morphology and functionality of the brain. Recent research indicates that functional integration between multi-sensory, somato-motor, default-mode (DMN), and salience (SN) networks of the brain differentiates musicians from non-musicians during resting state. Here, we aimed at ...

journal_title：Human brain mapping

authors： Alluri V,Toiviainen P,Burunat I,Kliuchko M,Vuust P,Brattico E

更新日期：2017-06-01 00:00:00

abstract：:Developmental neuropsychology and functional neuroimaging evidence indicates that simple and complex mental calculation is subserved by a fronto-parietal network. However, the effective connectivity (connection direction and strength) among regions within the fronto-parietal network is still unexplored. Combining even...

journal_title：Human brain mapping

authors： Krueger F,Landgraf S,van der Meer E,Deshpande G,Hu X

更新日期：2011-09-01 00:00:00

abstract：:Increased cerebral blood flow in the anterior cingulate cortex (ACC) has been noted in a range of cognitively demanding tasks studied with PET. A PET study of 10 normal males was carried out using the bolus H2(15)O intravenous injection technique to examine the effects of anticipation on blood flow to the ACC. In a se...

journal_title：Human brain mapping

authors： Murtha S,Chertkow H,Beauregard M,Dixon R,Evans A

更新日期：1996-01-01 00:00:00

abstract：:Numerous studies suggest that interhemispheric inhibition-relayed via the corpus callosum-plays an important role in unilateral hand motions. Interestingly, transcallosal inhibition appears to be indicative of a strong laterality effect, where generally the dominant hemisphere exerts inhibition on the nondominant one....

journal_title：Human brain mapping

authors： Kurth F,Mayer EA,Toga AW,Thompson PM,Luders E

更新日期：2013-09-01 00:00:00

abstract：:Previous research in young adults has demonstrated that both motor learning and transcranial direct current stimulation (tDCS) trigger decreases in the levels of gamma-aminobutyric acid (GABA) in the sensorimotor cortex, and these decreases are linked to greater learning. Less is known about the role of GABA in motor ...

journal_title：Human brain mapping

authors： King BR,Rumpf JJ,Verbaanderd E,Heise KF,Dolfen N,Sunaert S,Doyon J,Classen J,Mantini D,Puts NAJ,Edden RAE,Albouy G,Swinnen SP

更新日期：2020-09-01 00:00:00

abstract：:Ten healthy adults encountered pictures of unfamiliar archaic tools and successfully learned either their name, verbal definition of their usage, or both. Neural representation of the newly acquired information was probed with magnetoencephalography in an overt picture-naming task before and after learning, and in two...

journal_title：Human brain mapping

authors： Hultén A,Vihla M,Laine M,Salmelin R

更新日期：2009-03-01 00:00:00

abstract：:The question of how spatially organized activity in the visual cortex behaves during eyes-closed, lysergic acid diethylamide (LSD)-induced "psychedelic imagery" (e.g., visions of geometric patterns and more complex phenomena) has never been empirically addressed, although it has been proposed that under psychedelics, ...

journal_title：Human brain mapping

authors： Roseman L,Sereno MI,Leech R,Kaelen M,Orban C,McGonigle J,Feilding A,Nutt DJ,Carhart-Harris RL

更新日期：2016-08-01 00:00:00

abstract：:Resection of the seizure generating tissue can be highly beneficial in patients with drug-resistant epilepsy. However, only about half of all patients undergoing surgery get permanently and completely seizure free. Investigating the dependences between intracranial EEG signals adds a multivariate perspective largely u...

journal_title：Human brain mapping

authors： Müller M,Caporro M,Gast H,Pollo C,Wiest R,Schindler K,Rummel C

更新日期：2020-02-01 00:00:00

abstract：:Altered serotonergic neurotransmission has been found to cause impulsive and aggressive behavior, as well as increased motor activity, all exemplifying key symptoms of ADHD. The main objectives of this positron emission tomography (PET) study were to investigate the serotonin transporter binding potential (SERT BPND )...

journal_title：Human brain mapping

authors： Vanicek T,Kutzelnigg A,Philippe C,Sigurdardottir HL,James GM,Hahn A,Kranz GS,Höflich A,Kautzky A,Traub-Weidinger T,Hacker M,Wadsak W,Mitterhauser M,Kasper S,Lanzenberger R

更新日期：2017-02-01 00:00:00

abstract：:We describe a method for the statistical parametric mapping of low resolution electromagnetic tomography (LORETA) using high-density electroencephalography (EEG) and individual magnetic resonance images (MRI) to investigate the characteristics of the mismatch negativity (MMN) generators in schizophrenia. LORETA, using...

journal_title：Human brain mapping

authors： Park HJ,Kwon JS,Youn T,Pae JS,Kim JJ,Kim MS,Ha KS

更新日期：2002-11-01 00:00:00

abstract：:Gait disturbances, including freezing of gait, are frequent and disabling symptoms of Parkinson's disease. They often respond poorly to dopaminergic treatments. Although recent studies have shed some light on their neural correlates, their modulation by dopaminergic treatment remains quite unknown. Specifically, the i...

journal_title：Human brain mapping

authors： Maillet A,Thobois S,Fraix V,Redouté J,Le Bars D,Lavenne F,Derost P,Durif F,Bloem BR,Krack P,Pollak P,Debû B

更新日期：2015-03-01 00:00:00

abstract：:Classical delay eyeblink conditioning is likely the most commonly used paradigm to study cerebellar learning. As yet, few studies have focused on extinction and savings of conditioned eyeblink responses (CRs). Saving effects, which are reflected in a reacquisition after extinction that is faster than the initial acqui...

journal_title：Human brain mapping

authors： Ernst TM,Thürling M,Müller S,Kahl F,Maderwald S,Schlamann M,Boele HJ,Koekkoek SKE,Diedrichsen J,De Zeeuw CI,Ladd ME,Timmann D

更新日期：2017-08-01 00:00:00

abstract：:Patients with epilepsy are often able to predict seizure occurrence subsequent to an acute stress experience. However, neuroimaging investigations into the neural basis of this relationship or the potential influence of perceived life stress are limited. The current study assessed the relationship between perceived st...

journal_title：Human brain mapping

authors： Goodman AM,Allendorfer JB,Heyse H,Szaflarski BA,Eliassen JC,Nelson EB,Storrs JM,Szaflarski JP

更新日期：2019-08-15 00:00:00

abstract：:To generate imaging biomarkers from disease-specific brain networks, we have implemented a general toolbox to rapidly perform scaled subprofile modeling (SSM) based on principal component analysis (PCA) on brain images of patients and normals. This SSMPCA toolbox can define spatial covariance patterns whose expression...

journal_title：Human brain mapping

authors： Peng S,Ma Y,Spetsieris PG,Mattis P,Feigin A,Dhawan V,Eidelberg D

更新日期：2014-05-01 00:00:00

abstract：:Previous studies showed that neurons in the monkey premotor cortex became active when performing a particular action and also when observing the same action performed by others. These findings suggest a mirror system for action observation. Recently, bimodal neurons, sensitive both to visual and tactile stimulation, w...

journal_title：Human brain mapping

authors： Schaefer M,Xu B,Flor H,Cohen LG

更新日期：2009-09-01 00:00:00

abstract：:The presence of white matter lesions in patients with cerebral small vessel disease (SVD) is among the main causes of cognitive decline. We investigated the relation between white matter hyperintensity (WMH) locations and executive and language abilities in 442 SVD patients without dementia with varying burden of WMH....

journal_title：Human brain mapping

authors： Camerino I,Sierpowska J,Reid A,Meyer NH,Tuladhar AM,Kessels RPC,de Leeuw FE,Piai V

更新日期：2020-11-24 00:00:00

abstract：:BOLD functional MRI (fMRI) data are dominated by low frequency signals, many of them of unclear origin. We have recently shown that some portions of the low frequency oscillations found in BOLD fMRI are systemic signals closely related to the blood circulation (Tong et al. [2013]: NeuroImage 76:202-215). They are comm...

journal_title：Human brain mapping

authors： Tong Y,Frederick Bd

更新日期：2014-11-01 00:00:00

abstract：:The anterior limb of the internal capsule (ALIC) is an important locus of frontal-subcortical fiber tracts involved in cognitive and limbic feedback loops. However, the structural organization of its component fiber tracts remains unclear. Therefore, although the ALIC is a promising target for various neurosurgical pr...

journal_title：Human brain mapping

authors： Nanda P,Banks GP,Pathak YJ,Sheth SA

更新日期：2017-12-01 00:00:00

abstract：:Transcranial magnetic stimulation (TMS) during positron emission tomography (PET) is a novel technique for in vivo measurements of connectivity and excitability of the human cerebral cortex. Here we describe tools that allow investigators to position the stimulating coil over a target region and to verify the actual p...

journal_title：Human brain mapping

authors： Paus T,Wolforth M

更新日期：1998-01-01 00:00:00

abstract：:There is still no clear consensus as to which of the many functional and structural changes in the brain in schizophrenia are of most importance, although the main focus to date has been on those in the frontal and cingulate cortices. In the present study, we have used a novel holistic approach to identify brain-wide ...

journal_title：Human brain mapping

authors： Guo S,Kendrick KM,Yu R,Wang HL,Feng J

更新日期：2014-01-01 00:00:00

abstract：:This study investigates the (re-)organization of somatosensory functions following early brain lesions. Using functional magnetic resonance imaging (fMRI), passive hand movement was studied. Transcranial magnetic stimulation (TMS) and magnetoencephalography (MEG) were used as complementary methods. fMRI data was analy...

journal_title：Human brain mapping

authors： Wilke M,Staudt M,Juenger H,Grodd W,Braun C,Krägeloh-Mann I

更新日期：2009-03-01 00:00:00

abstract：:We monitored regional cerebral activity with BOLD fMRI while subjects were presented written sentences differing in their grammatical structure (subject-relative or object-relative center-embedded clauses) and their short-term memory demands (short or long antecedent-gap linkages). A core region of left posterior supe...

journal_title：Human brain mapping

authors： Cooke A,Zurif EB,DeVita C,Alsop D,Koenig P,Detre J,Gee J,Pinãngo M,Balogh J,Grossman M

更新日期：2002-02-01 00:00:00

abstract：:Experienced video game players exhibit superior performance in visuospatial cognition when compared to non-players. However, very little is known about the relation between video game experience and structural brain plasticity. To address this issue, a direct comparison of the white matter brain structure in RTS (real...

journal_title：Human brain mapping

authors： Kowalczyk N,Shi F,Magnuski M,Skorko M,Dobrowolski P,Kossowski B,Marchewka A,Bielecki M,Kossut M,Brzezicka A

更新日期：2018-09-01 00:00:00

abstract：:Catechol-O-methyltransferase (COMT), located on chromosome 22q11.2, encodes an enzyme critical for dopamine flux in the prefrontal cortex. Genetic variants of COMT have been suggested to functionally manipulate prefrontal morphology and function in healthy adults. This study aims to investigate modulative roles of ind...

journal_title：Human brain mapping

authors： Lee A,Qiu A

更新日期：2016-06-01 00:00:00

abstract：:The amygdala, a small deep brain structure involved in behavioral processing through interactions with other brain regions, has garnered increased attention in recent years in relation to pain processing. As pain is a multidimensional experience that encompasses physical sensation, affect, and cognition, the amygdala ...

journal_title：Human brain mapping

authors： Simons LE,Moulton EA,Linnman C,Carpino E,Becerra L,Borsook D

更新日期：2014-02-01 00:00:00

abstract：:The resting state default mode network (DMN) has been shown to characterize a number of neurological and psychiatric disorders. Evidence suggests an underlying genetic basis for this network and hence could serve as potential endophenotype for these disorders. Heritability is a defining criterion for endophenotypes. T...

journal_title：Human brain mapping

authors： Korgaonkar MS,Ram K,Williams LM,Gatt JM,Grieve SM

更新日期：2014-08-01 00:00:00

abstract：:In social interactions, humans are expected to regulate interpersonal distance in response to the emotion displayed by others. Yet, the neural mechanisms implicated in approach-avoidance tendencies to distinct emotional expressions have not been fully described. Here, we investigated the neural systems implicated in r...

journal_title：Human brain mapping

authors： Vieira JB,Tavares TP,Marsh AA,Mitchell DG

更新日期：2017-03-01 00:00:00

abstract：:Non-quantitative MRI is prone to intersubject intensity variation rendering signal intensity level based analyses limited. Here, we propose a method that fuses non-quantitative routine T1-weighted (T1w), T2w, and T2w fluid-saturated inversion recovery sequences using independent component analysis and validate it on a...

journal_title：Human brain mapping

authors： Papazoglou S,Würfel J,Paul F,Brandt AU,Scheel M

更新日期：2017-07-01 00:00:00

abstract：:The dopaminergic system plays a key role in motor function and motor abnormalities have been shown to be a specific feature of psychosis. Due to their dopaminergic action, antipsychotic drugs may be expected to modulate motor function, but the precise effects of these drugs on motor function remain unclear. We carried...

journal_title：Human brain mapping

authors： Goozee R,O'Daly O,Handley R,Reis Marques T,Taylor H,McQueen G,Hubbard K,Pariante C,Mondelli V,Reinders AA,Dazzan P

更新日期：2017-04-01 00:00:00

abstract：:Our objective was to develop a diffusion tensor MR imaging pulse sequence that allows whole brain coverage with isotropic resolution within a clinically acceptable time. A single-shot, cardiac-gated MR pulse sequence, optimized for measuring the diffusion tensor in human brain, was developed to provide whole-brain cov...

journal_title：Human brain mapping

authors： Jones DK,Williams SC,Gasston D,Horsfield MA,Simmons A,Howard R

更新日期：2002-04-01 00:00:00