Abstract:
:Medial temporal lobe (MTL) subregions play integral roles in memory function and are differentially affected in various neurological and psychiatric disorders. The ability to structurally and functionally characterize these subregions may be important to understanding MTL physiology and diagnosing diseases involving the MTL. In this study, we characterized network architecture of the MTL in healthy subjects (n = 31) using both resting state functional MRI and MTL-focused T2-weighted structural MRI at 7 tesla. Ten MTL subregions per hemisphere, including hippocampal subfields and cortical regions of the parahippocampal gyrus, were segmented for each subject using a multi-atlas algorithm. Both structural covariance matrices from correlations of subregion volumes across subjects, and functional connectivity matrices from correlations between subregion BOLD time series were generated. We found a moderate structural and strong functional inter-hemispheric symmetry. Several bilateral hippocampal subregions (CA1, dentate gyrus, and subiculum) emerged as functional network hubs. We also observed that the structural and functional networks naturally separated into two modules closely corresponding to (a) bilateral hippocampal formations, and (b) bilateral extra-hippocampal structures. Finally, we found a significant correlation in structural and functional connectivity (r = 0.25). Our findings represent a comprehensive analysis of network topology of the MTL at the subregion level. We share our data, methods, and findings as a reference for imaging methods and disease-based research.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Shah P,Bassett DS,Wisse LEM,Detre JA,Stein JM,Yushkevich PA,Shinohara RT,Pluta JB,Valenciano E,Daffner M,Wolk DA,Elliott MA,Litt B,Davis KA,Das SRdoi
10.1002/hbm.23887subject
Has Abstractpub_date
2018-02-01 00:00:00pages
851-865issue
2eissn
1065-9471issn
1097-0193journal_volume
39pub_type
杂志文章abstract::The registration of image volumes derived from different imaging modalities such as MRI, PET, SPECT, and CT has been described in numerous studies in which functional and morphological data are combined on the basis of macrostructural information. However, the exact topography of architectural details is defined by mi...
journal_title:Human brain mapping
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journal_title:Human brain mapping
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journal_title:Human brain mapping
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journal_title:Human brain mapping
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pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 临床试验,杂志文章,随机对照试验
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