Abstract:
:The development of treatments for attention impairments is hampered by limited knowledge about the malleability of underlying neural functions. We conducted the first randomized controlled trial to determine the modulations of brain activity associated with working memory (WM) training in adults with attention-deficit hyperactivity disorder (ADHD). At baseline, we assessed the aberrant functional brain activity in the n-back WM task by comparing 44 adults with ADHD with 18 healthy controls using fMRI. Participants with ADHD were then randomized to train on an adaptive dual n-back task or an active control task. We tested whether WM training elicits redistribution of brain activity as observed in healthy controls, and whether it might further restore aberrant activity related to ADHD. As expected, activity in areas of the default-mode (DMN), salience (SN), sensory-motor (SMN), frontoparietal (FPN), and subcortical (SCN) networks was decreased in participants with ADHD at pretest as compared with healthy controls, especially when the cognitive load was high. WM training modulated widespread FPN and SN areas, restoring some of the aberrant activity. Training effects were mainly observed as decreased brain activity during the trained task and increased activity during the untrained task, suggesting different neural mechanisms for trained and transfer tasks.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Salmi J,Soveri A,Salmela V,Alho K,Leppämäki S,Tani P,Koski A,Jaeggi SM,Laine Mdoi
10.1002/hbm.25164subject
Has Abstractpub_date
2020-12-01 00:00:00pages
4876-4891issue
17eissn
1065-9471issn
1097-0193journal_volume
41pub_type
杂志文章abstract::Standard procedures to achieve quality assessment (QA) of functional magnetic resonance imaging (fMRI) data are of great importance. A standardized and fully automated procedure for QA is presented that allows for classification of data quality and the detection of artifacts by inspecting temporal variations. The appl...
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journal_title:Human brain mapping
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journal_title:Human brain mapping
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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