Volumetric and shape analysis of the thalamus in first-episode schizophrenia.

Abstract:

:Thalamic abnormalities have been implicated in the pathogenesis of schizophrenia, although the majority of studies used chronic samples treated extensively with antipsychotics. Moreover, the clinical and neuropsychological correlates of these abnormalities remain largely unknown. Using high-resolution MR imaging and novel methods for shape analysis, we investigated thalamic subregions in 35 (25 M/10 F) first-episode schizophrenia patients compared with 33 (23 M/10 F) healthy volunteers. The right and left thalami were traced bilaterally on coronal brain slices and volumes were compared between groups. In addition, regional abnormalities were identified by comparing distances, measured from homologous thalamic surface points to the central core of each individual's surface model, between groups in 3D space. Patients had significantly less total thalamic volume compared with healthy volunteers. Statistical mapping demonstrated most pronounced shape abnormalities in the pulvinar; however, estimated false discovery rates in these regions were sizable. Smaller thalamus volume was significantly correlated with worse overall neuropsychological functioning and specific deficits were observed in the language, motor, and executive domains. There were no significant associations between thalamus volume and positive or negative symptoms. Our findings suggest that thalamic abnormalities are evident at the onset of a first episode of schizophrenia prior to extensive pharmacologic intervention and that these abnormalities have neuropsychological correlates.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Coscia DM,Narr KL,Robinson DG,Hamilton LS,Sevy S,Burdick KE,Gunduz-Bruce H,McCormack J,Bilder RM,Szeszko PR

doi

10.1002/hbm.20595

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

1236-45

issue

4

eissn

1065-9471

issn

1097-0193

journal_volume

30

pub_type

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