Abstract:
:Neuroimaging studies in humans have consistently found robust activation of frontal, parietal, and temporal regions during working memory tasks. Whether these activations represent functional networks segregated by perceptual domain is still at issue. Two functional magnetic resonance imaging experiments were conducted, both of which used multiple-cycle, alternating task designs. Experiment 1 compared spatial and object working memory tasks to identify cortical regions differentially activated by these perceptual domains. Experiment 2 compared working memory and perceptual control tasks within each of the spatial and object domains to determine whether the regions identified in experiment 1 were driven primarily by the perceptual or mnemonic demands of the tasks, and to identify common brain regions activated by working memory in both perceptual domains. Domain-specific activation occurred in the inferior parietal cortex for spatial tasks, and in the inferior occipitotemporal cortex for object tasks, particularly in the left hemisphere. However, neither area was strongly influenced by task demands, being nearly equally activated by the working memory and perceptual control tasks. In contrast, activation of the dorsolateral prefrontal cortex and the intraparietal sulcus (IPS) was strongly task-related. Spatial working memory primarily activated the right middle frontal gyrus (MFG) and the IPS. Object working memory activated the MFG bilaterally, the left inferior frontal gyrus, and the IPS, particularly in the left hemisphere. Finally, activation of midline posterior regions, including the cingulate gyrus, occurred at the offset of the working memory tasks, particularly the shape task. These results support a prominent role of the prefrontal and parietal cortices in working memory, and indicate that spatial and object working memory tasks recruit differential hemispheric networks. The results also affirm the distinction between spatial and object perceptual processing in dorsal and ventral visual pathways.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Belger A,Puce A,Krystal JH,Gore JC,Goldman-Rakic P,McCarthy Gsubject
Has Abstractpub_date
1998-01-01 00:00:00pages
14-32issue
1eissn
1065-9471issn
1097-0193pii
10.1002/(SICI)1097-0193(1998)6:1<14::AID-HBM2>3.0.journal_volume
6pub_type
临床试验,杂志文章,随机对照试验abstract::One of our highest evolved functions as human beings is our capacity to switch between multiple tasks effectively. A body of research has identified a distributed frontoparietal network of brain regions which contribute to task switching. However, relatively less is known about whether some brain regions may contribut...
journal_title:Human brain mapping
pub_type: 杂志文章,meta分析
doi:10.1002/hbm.21199
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abstract::Ten healthy adults encountered pictures of unfamiliar archaic tools and successfully learned either their name, verbal definition of their usage, or both. Neural representation of the newly acquired information was probed with magnetoencephalography in an overt picture-naming task before and after learning, and in two...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20561
更新日期:2009-03-01 00:00:00
abstract::Whether neuroimaging findings support discriminable neural correlates of emotion categories is a longstanding controversy. Two recent meta-analyses arrived at opposite conclusions, with one supporting (Vytal and Hamann []: J Cogn Neurosci 22:2864-2885) and the other opposing this proposition (Lindquist et al. []: Beha...
journal_title:Human brain mapping
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doi:10.1002/hbm.22910
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abstract::Auditory steady-state responses (ASSRs) are evoked brain responses to modulated or repetitive acoustic stimuli. Investigating the underlying neural generators of ASSRs is important to gain in-depth insight into the mechanisms of auditory temporal processing. The aim of this study is to reconstruct an extensive range o...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25262
更新日期:2021-02-15 00:00:00
abstract::White matter (WM) microstructure, as determined by diffusion tensor imaging (DTI), is increasingly recognized as an important determinant of cognitive function and is also altered in neuropsychiatric disorders. Little is known about genetic and environmental influences on WM microstructure, especially in early childho...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24436
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abstract::Fluent readers process written text rapidly and accurately, and comprehend what they read. Historically, reading fluency has been modeled as the product of discrete skills such as single word decoding. More recent conceptualizations emphasize that fluent reading is the product of competency in, and the coordination of...
journal_title:Human brain mapping
pub_type: 杂志文章
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abstract::Active motor functional magnetic resonance imaging (fMRI) studies have shown that pediatric multiple sclerosis (MS) patients have a strictly lateralized pattern of activations and a preserved functional connectivity (FC) within the motor system when compared to age-matched healthy controls. However, it is still not cl...
journal_title:Human brain mapping
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1002/hbm.23188
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abstract::It has recently been demonstrated that specific patterns of correlation exist in diffusion tensor imaging (DTI) parameters across white matter tracts in the normal human brain. These microstructural correlations are thought to reflect phylogenetic and functional similarities between different axonal fiber pathways. Ho...
journal_title:Human brain mapping
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abstract::Successful response selection relies on constantly updating stimulus-response associations. The Theory of Event Coding (TEC) proposes that perception and action are conjointly coded in event files, for which fronto-striatal networks seem to play an important role. However, the exact neurobiochemical mechanism behind e...
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pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21372
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22401
更新日期:2014-07-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23130
更新日期:2016-05-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20858
更新日期:2010-02-01 00:00:00
abstract::Our primary question was to learn whether mentally composing drawings of their own choice produce different brain electric features in artists and laymen. To this purpose, we studied multichannel electroencephalograph (EEG) signals from two broad groups (all participants were females): artists (professionally trained ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20104
更新日期:2005-09-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章,meta分析
doi:10.1002/hbm.24747
更新日期:2019-12-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20532
更新日期:2009-02-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24960
更新日期:2020-06-15 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1996)4:2<103::AID-HBM2>3.0
更新日期:1996-01-01 00:00:00
abstract::We sought to determine whether functional connectivity streams that link sensory, attentional, and higher-order cognitive circuits are atypical in attention-deficit/hyperactivity disorder (ADHD). We applied a graph-theory method to the resting-state functional magnetic resonance imaging data of 120 children with ADHD ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22790
更新日期:2015-07-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20292
更新日期:2007-07-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23093
更新日期:2016-03-01 00:00:00
abstract::Functional imaging studies consistently find that emotional stimuli activate the posterior cingulate cortex, a region that appears to have memory-related functions. However, prior imaging studies have not controlled for non-emotional stimulus features that might activate this region by engaging memory processes unrela...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.10075
更新日期:2003-01-01 00:00:00
abstract::Many studies have shown the involvement of the premotor cortex in action observation, recognizing this region as the neural marker of action simulation (i.e., internal modeling on the basis of the observer's own motor repertoire). So far, however, we have remained unaware of how action simulation differs from more gen...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20949
更新日期:2011-05-01 00:00:00
abstract::Anxiety arising during pain expectancy can modulate the subjective experience of pain. However, individuals differ in their sensitivity to pain expectancy. The amygdale and hippocampus were proposed to mediate the behavioral response to aversive stimuli. However, their differential role in mediating anxiety-related in...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20867
更新日期:2010-02-01 00:00:00
abstract::Brain morphometry based classification from magnetic resonance (MR) acquisitions has been widely investigated in the diagnosis of Alzheimer's disease (AD) and its prodromal stage, i.e., mild cognitive impairment (MCI). In the literature, a morphometric representation of brain structures is obtained by spatial normaliz...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22531
更新日期:2014-10-01 00:00:00
abstract::Major depressive disorder (MDD) is highly prevalent and associated with considerable morbidity, yet its pathophysiology remains only partially understood. While numerous studies have investigated the neurobiological correlates of MDD, most have used only a single neuroimaging modality. In particular, diffusion tensor ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24679
更新日期:2019-09-01 00:00:00
abstract::The development of treatments for attention impairments is hampered by limited knowledge about the malleability of underlying neural functions. We conducted the first randomized controlled trial to determine the modulations of brain activity associated with working memory (WM) training in adults with attention-deficit...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25164
更新日期:2020-12-01 00:00:00
abstract::Impairment in controlled semantic association is a central feature of schizophrenia, and the goal of the current functional magnetic resonance imaging study was to identify the neural correlates of this impairment. Thirty people with schizophrenia and 30 healthy age- and gender-matched control subjects performed a tas...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22820
更新日期:2015-08-01 00:00:00