Abstract:
:Although reduced working memory brain activation has been reported in several brain regions of cocaine-dependent subjects compared with controls, very little is known about whether there is altered connectivity of working memory pathways in cocaine dependence. This study addresses this issue by using functional magnetic resonance imaging-based stochastic dynamic causal modeling (DCM) analysis to study the effective connectivity of 19 cocaine-dependent subjects and 14 healthy controls while performing a working memory task. Stochastic DCM is an advanced method that has recently been implemented in SPM8 that can obtain improved estimates, relative to deterministic DCM, of hidden neuronal causes before convolution with the hemodynamic response. Thus, stochastic DCM may be less influenced by the confounding effects of variations in blood oxygen level-dependent response caused by disease or drugs. Based on the significant regional activation common to both groups and consistent with previous working memory activation studies, seven regions of interest were chosen as nodes for DCM analyses. Bayesian family level inference, Bayesian model selection analyses, and Bayesian model averaging (BMA) were conducted. BMA showed that the cocaine-dependent subjects had large differences compared with the control subjects in the strengths of prefrontal-striatal modulatory (B matrix) DCM parameters. These findings are consistent with altered cortical-striatal networks that may be related to reduced dopamine function in cocaine dependence. As far as we are aware, this is the first between-group DCM study using stochastic methodology.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Ma L,Steinberg JL,Hasan KM,Narayana PA,Kramer LA,Moeller FGdoi
10.1002/hbm.22212subject
Has Abstractpub_date
2014-03-01 00:00:00pages
760-78issue
3eissn
1065-9471issn
1097-0193journal_volume
35pub_type
杂志文章abstract::Chemosensory-based communication is a vital signaling tool in most species, and evidence has recently emerged in support of the notion that humans also use social chemosignals (so-called pheromones) to communicate. An ongoing controversy does exist, however, concerning the receptor organ through which these chemicals ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21035
更新日期:2011-03-01 00:00:00
abstract::Magnetic resonance imaging of subcortical gray matter structures, which mediate behavior, cognition and the pathophysiology of several diseases, is crucial for establishing typical maturation patterns across the human lifespan. This single site study examines T1-weighted MPRAGE images of 3 healthy cohorts: (i) a cross...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23604
更新日期:2017-08-01 00:00:00
abstract::Musical expertise is visible both in the morphology and functionality of the brain. Recent research indicates that functional integration between multi-sensory, somato-motor, default-mode (DMN), and salience (SN) networks of the brain differentiates musicians from non-musicians during resting state. Here, we aimed at ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23565
更新日期:2017-06-01 00:00:00
abstract::Vitamin D deficiency may exacerbate adverse neurocognitive outcomes in the progression of diseases such as Parkinson's, Alzheimer's, and other dementias. Mild cognitive impairment (MCI) is prodromal for these neurocognitive disorders and neuroimaging studies suggest that, in the elderly, this cognitive impairment is a...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24380
更新日期:2019-02-01 00:00:00
abstract::Playing music requires a strong coupling of perception and action mediated by multimodal integration of brain regions, which can be described as network connections measured by anatomical and functional correlations between regions. However, the structural and functional connectivities within and between the auditory ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23989
更新日期:2018-05-01 00:00:00
abstract::Previous findings have shown that the human somatosensory cortical systems that are activated by passive nonpainful electrical stimulation include the contralateral primary somatosensory area (SI), bilateral secondary somatosensory area (SII), and bilateral insula. The present study tested the hypothesis that these ar...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20292
更新日期:2007-07-01 00:00:00
abstract::Coordinate-based, voxel-wise meta-analysis is an exciting recent addition to the human functional brain mapping literature. In view of the critical importance of selection criteria for any valid meta-analysis, a taxonomy of experimental design should be an important tool for aiding in the design of rigorous meta-analy...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20141
更新日期:2005-05-01 00:00:00
abstract::Classically, model-based segmentation procedures match magnetic resonance imaging (MRI) volumes to an expertly labeled atlas using nonlinear registration. The accuracy of these techniques are limited due to atlas biases, misregistration, and resampling error. Multi-atlas-based approaches are used as a remedy and invol...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22092
更新日期:2013-10-01 00:00:00
abstract::Parkinsonism has heterogeneous nature, showing distinctive patterns of disease progression and prognosis. We aimed to find clusters of parkinsonism based on 18 F-fluoropropyl-carbomethoxyiodophenylnortropane (FP-CIT) PET as a data-driven approach to evaluate heterogenous dopaminergic neurodegeneration patterns. Two di...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25155
更新日期:2020-11-01 00:00:00
abstract::Resting-state studies conducted with stroke patients are scarce. The study of brain activity and connectivity at rest provides a unique opportunity for the investigation of brain rewiring after stroke and plasticity changes. This study sought to identify dynamic changes in the functional organization of the default mo...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22648
更新日期:2015-02-01 00:00:00
abstract::Investigation of the brain's white matter fiber tracts in social anxiety disorder (SAD) may provide insight into the underlying pathophysiology. Because models of pathological anxiety posit altered frontolimbic interactions, the uncinate fasciculus (UF) connecting (orbito-) frontal and temporal areas including the amy...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21447
更新日期:2013-02-01 00:00:00
abstract::MR-based measurements of brain volumes may be affected by the presence of white matter (WM) lesions. Here, we assessed how and to what extent this may happen for WM lesions of various sizes and intensities. After inserting WM lesions of different sizes and intensities into T1-W brain images of healthy subjects, we ass...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21344
更新日期:2012-09-01 00:00:00
abstract::Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that alters cortical excitability and activity in a polarity-dependent way. Stimulation for few minutes has been shown to induce plastic alterations of cortical excitability and to improve cognitive performance. These effects m...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21104
更新日期:2011-08-01 00:00:00
abstract::Previous studies have demonstrated that the right ventrolateral prefrontal cortex (RVLPFC) is crucially involved in downregulating physical and social pain. However, it remains unclear whether the RVLPFC is more specific to either physical or social pain. The present study compares the role of RVLPFC in emotion regula...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24881
更新日期:2020-04-01 00:00:00
abstract::Ten healthy adults encountered pictures of unfamiliar archaic tools and successfully learned either their name, verbal definition of their usage, or both. Neural representation of the newly acquired information was probed with magnetoencephalography in an overt picture-naming task before and after learning, and in two...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20561
更新日期:2009-03-01 00:00:00
abstract::Major depressive disorder (MDD) is highly prevalent and associated with considerable morbidity, yet its pathophysiology remains only partially understood. While numerous studies have investigated the neurobiological correlates of MDD, most have used only a single neuroimaging modality. In particular, diffusion tensor ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24679
更新日期:2019-09-01 00:00:00
abstract::What is the neural substrate of our capability to properly react to changes in the environment? It can be hypothesized that the anterior cingulate cortex (ACC) manages repetitive stimuli in routine conditions and alerts the dorsolateral prefrontal cortex (PFC) when stimulation unexpectedly changes. To provide evidence...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20491
更新日期:2009-01-01 00:00:00
abstract::Cortical hubs play a fundamental role in the functional architecture of brain connectivity at rest. However, the anatomical scaffold underlying their centrality is still under debate. Certainly, the brain function and anatomy are significantly entwined through synaptogenesis and pruning mechanisms that continuously re...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23721
更新日期:2017-10-01 00:00:00
abstract::Threatening stimuli have been found to modulate visual processes related to perception and attention. The present functional magnetic resonance imaging (fMRI) study investigated whether threat modulates visual object recognition of man-made and naturally occurring categories of stimuli. Compared with nonthreatening pi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22039
更新日期:2013-08-01 00:00:00
abstract::The goal of this study was to document current clinical practice and report patient outcomes in presurgical language functional MRI (fMRI) for epilepsy surgery. Epilepsy surgical programs worldwide were surveyed as to the utility, implementation, and efficacy of language fMRI in the clinic; 82 programs responded. Resp...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24039
更新日期:2018-07-01 00:00:00
abstract::Prenatal alcohol exposure (PAE) can cause central nervous system dysfunction and widespread structural anomalies as detected by magnetic resonance imaging (MRI). This study focused on diffusion tensor imaging (DTI) of white matter in a large sample of PAE participants that allowed us to examine correlations with behav...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23371
更新日期:2017-01-01 00:00:00
abstract::Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deforma...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22214
更新日期:2014-03-01 00:00:00
abstract::Standardized psychometric tests are sophisticated, well-developed, and consequential instruments; test outcomes are taken as facts about people that impact their lives in important ways. As part of an initial demonstration that human brain mapping techniques can add converging neural-level evidence to understanding st...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23761
更新日期:2017-11-01 00:00:00
abstract::Word production is a complex multistage process linking conceptual representations, lexical entries, phonological forms and articulation. Previous studies have revealed a network of predominantly left-lateralized brain regions supporting this process, but many details regarding the precise functions of different nodes...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20782
更新日期:2009-11-01 00:00:00
abstract::Task-based functional neuroimaging methods are increasingly being used to identify biomarkers of treatment response in psychiatric disorders. To facilitate meaningful interpretation of neural correlates of tasks and their potential changes with treatment over time, understanding the reliability of the blood-oxygen-lev...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24883
更新日期:2020-04-15 00:00:00
abstract::We systematically investigated the effects of cathodal and anodal Transcranial Direct Current Stimulation (CtDCS, AtDCS) on the electric activity of primary motor cortex during a motor task. High-density electroencephalography was used to define the spatial diffusion of tDCS after effects. Ten healthy subjects perform...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22322
更新日期:2014-05-01 00:00:00
abstract::Recent theories of selective attention assume that the more attention is required by a task, the earlier are irrelevant stimuli filtered during perceptual processing. Previous functional MRI studies have demonstrated that primary visual cortex (V1) activation by peripheral distractors is reduced by higher task difficu...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20636
更新日期:2009-05-01 00:00:00
abstract::The relationship between neocortical structure and function is a key area of research in neuroscience. Most studies of neural function, whether using neurophysiology or neuroimaging methods, are interpreted with relation to the underlying cortical myelo- and cytoarchitecture. For functional neuroimaging studies this o...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20162
更新日期:2005-12-01 00:00:00
abstract::Everyday communication is accompanied by visual information from several sources, including co-speech gestures, which provide semantic information listeners use to help disambiguate the speaker's message. Using fMRI, we examined how gestures influence neural activity in brain regions associated with processing semanti...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20774
更新日期:2009-11-01 00:00:00
abstract::In daily life, we permanently need to adapt our behavior to new task situations, requiring cognitive control. Such adaptive processes are commonly investigated with the task-switching paradigm. Many fMRI studies have interpreted stronger activation for switch than repeat trials in fronto-parietal brain areas as reflec...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21234
更新日期:2012-03-01 00:00:00