Abstract:
:Differences in brain activity of children with attention deficit hyperactivity disorder (ADHD) have been compared to normal healthy controls, suggesting neural correlates of cognitive/behavioral symptoms. Symptoms are improved with methylphenidate treatment but limited sources can be cited to show how brain activity in ADHD is altered after pharmacologic treatment. We investigated how long-term oral medication of methylphenidate affects the resting regional cerebral blood flow (rCBF) in ADHD children, using single photon emission computerized tomography (SPECT). rCBF was decreased in the orbitofrontal cortex and middle temporal gyrus in the right hemisphere whereas it was increased in the dorsomedial prefrontal and somatosensory area bilaterally in drug-naive ADHD children compared to control child subjects. After treatment with methylphenidate, the extent of hyperperfusion in the somatosensory area was reduced and significant reduction of rCBF was found in the right striatum for the first time. Methylphenidate treatment also resulted in rCBF increase in superior prefrontal and reduction in ventral higher visual areas bilaterally. The results indicated that improving ADHD symptom after methylphenidate is associated with normalization of abnormally reduced orbitofrontal activity and abnormally increased somatosensory cortical activity. These changes were accompanied with reduced striatum activity lower than that of normal controls. These changes might be associated with improving ADHD to control attention and motor response to irrelevant environmental stimuli after methylphenidate treatment.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Lee JS,Kim BN,Kang E,Lee DS,Kim YK,Chung JK,Lee MC,Cho SCdoi
10.1002/hbm.20067keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
157-64issue
3eissn
1065-9471issn
1097-0193journal_volume
24pub_type
杂志文章abstract::Estimating the thickness of the cerebral cortex is a key step in many brain imaging studies, revealing valuable information on development or disease progression. In this work, we present a framework for measuring the cortical thickness, based on minimizing line integrals over the probability map of the gray matter in...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20740
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abstract::3,4-Methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a psychostimulant drug producing heightened mood and facilitated social communication. In animal studies, MDMA effects are primarily mediated by serotonin (5-HT), but also by dopamine (DA) and possibly noradrenaline (NA). In humans, however, the neurochemical and ...
journal_title:Human brain mapping
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::Characterizing the neurovascular coupling between hemodynamic signals and their neural origins is crucial to functional neuroimaging research, even more so as new methods become available for integrating results from different functional neuroimaging modalities. We present a novel method to relate magnetoencephalograp...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20361
更新日期:2008-01-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章,meta分析
doi:10.1002/hbm.20547
更新日期:2009-03-01 00:00:00
abstract::The goal of this study was to document current clinical practice and report patient outcomes in presurgical language functional MRI (fMRI) for epilepsy surgery. Epilepsy surgical programs worldwide were surveyed as to the utility, implementation, and efficacy of language fMRI in the clinic; 82 programs responded. Resp...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24039
更新日期:2018-07-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24564
更新日期:2019-07-01 00:00:00
abstract::We present an overview of the types of imaging experiments that can be performed on psychologically impaired patients. The critical observation from such studies is a differential pattern of activation in the patients and normals. Underactivity is interpretable only when the patients make normal responses. In this con...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0193(1999)8:2/3<102::aid-hbm6>3
更新日期:1999-01-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23989
更新日期:2018-05-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24794
更新日期:2020-01-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21032
更新日期:2011-03-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22201
更新日期:2014-02-01 00:00:00
abstract::Previous studies exploring the neural substrates of executive functioning used task-specific analyses, which might not be the most appropriate approach due to the difficulty of precisely isolating executive functions. Consequently, the aim of this study was to use positron emission tomography (PET) to reexamine by con...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20118
更新日期:2005-08-01 00:00:00
abstract::Fractal dimension (FD) has been widely used to provide a quantitative description of structural complexity in the cerebral cortex. FD is an extremely compact measure of shape complexity, condensing all details into a single numeric value. We interpreted the variation of the FD in the cortical surface of normal control...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20238
更新日期:2006-12-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22389
更新日期:2014-07-01 00:00:00
abstract::The human brain can be subdivided many ways depending upon the criteria used. One of the most basic approaches is to subdivide the cortical regions into functional units composed of the frontal, occipital, parietal, and temporal lobes. To date, the process of reliably extracting measurements of the human brain from MR...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1997)5:5<355::AID-HBM4>3.0
更新日期:1997-01-01 00:00:00
abstract::In early blindness, the primary visual area (PVA) loses the ability to process visual information, and shifts to working on the processing of somatosensory input, auditory input, and some higher-level cognitive functions. It has not yet been investigated whether such functional changes can lead to alterations of the f...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20420
更新日期:2008-05-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.25040
更新日期:2020-06-05 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章,多中心研究
doi:10.1002/hbm.23824
更新日期:2017-12-01 00:00:00
abstract::Studies of cognitive function that compare the blood oxygenation level dependent (BOLD) signal across age groups often require the assumption that neurovascular coupling does not change with age. Tests of this assumption have produced mixed results regarding the strength of the coupling and its relative time course. U...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23608
更新日期:2017-07-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21065
更新日期:2011-01-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24951
更新日期:2020-06-15 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24380
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(sici)1097-0193(1999)8:1<28::aid-hbm3>3.0.
更新日期:1999-01-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23574
更新日期:2017-06-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20132
更新日期:2005-05-01 00:00:00
abstract::Simultaneous electroencephalography and functional magnetic resonance imaging (EEG/fMRI) have been proposed to contribute to the definition of the epileptic seizure onset zone. Following interictal epileptiform discharges, one usually assumes a canonical hemodynamic response function (HRF), which has been derived from...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20925
更新日期:2010-08-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20868
更新日期:2010-03-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23860
更新日期:2018-01-01 00:00:00
abstract::What basic visual structures underlie human face detection and how can we extract such structures directly from the amplitude of neural responses elicited by face processing? Here, we address these issues by investigating an extension of noise-based image classification to BOLD responses recorded in high-level visual ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22128
更新日期:2013-11-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22178
更新日期:2014-01-01 00:00:00