Abstract:
:A subgroup of Parkinson's disease (PD) patients treated with dopaminergic therapy develop compulsive reward-driven behaviors, which can result in life-altering morbidity. The mesocorticolimbic dopamine network guides reward-motivated behavior; however, its role in this treatment-related behavioral phenotype is incompletely understood. Here, mesocorticolimbic network function in PD patients who develop impulsive and compulsive behaviors (ICB) in response to dopamine agonists was assessed using BOLD fMRI. The tested hypothesis was that network connectivity between the ventral striatum and the limbic cortex is elevated in patients with ICB and that reward-learning proficiency reflects the extent of mesocorticolimbic network connectivity. To evaluate this hypothesis, 3.0T BOLD-fMRI was applied to measure baseline functional connectivity on and off dopamine agonist therapy in age and sex-matched PD patients with (n = 19) or without (n = 18) ICB. An incentive-based task was administered to a subset of patients (n = 20) to quantify positively or negatively reinforced learning. Whole-brain voxelwise analyses and region-of-interest-based mixed linear effects modeling were performed. Elevated ventral striatal connectivity to the anterior cingulate gyrus (P = 0.013), orbitofrontal cortex (P = 0.034), insula (P = 0.044), putamen (P = 0.014), globus pallidus (P < 0.01), and thalamus (P < 0.01) was observed in patients with ICB. A strong trend for elevated amygdala-to-midbrain connectivity was found in ICB patients on dopamine agonist. Ventral striatum-to-subgenual cingulate connectivity correlated with reward learning (P < 0.01), but not with punishment-avoidance learning. These data indicate that PD-ICB patients have elevated network connectivity in the mesocorticolimbic network. Behaviorally, proficient reward-based learning is related to this enhanced limbic and ventral striatal connectivity. Hum Brain Mapp 39:509-521, 2018. © 2017 Wiley Periodicals, Inc.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Petersen K,Van Wouwe N,Stark A,Lin YC,Kang H,Trujillo-Diaz P,Kessler R,Zald D,Donahue MJ,Claassen DOdoi
10.1002/hbm.23860subject
Has Abstractpub_date
2018-01-01 00:00:00pages
509-521issue
1eissn
1065-9471issn
1097-0193journal_volume
39pub_type
杂志文章abstract::The posteromedial cortex (PMC) is a key region involved in the development and progression of Alzheimer's disease (AD). Previous studies have demonstrated a heterogenous functional architecture of the region that is composed of discrete functional modules reflecting a complex pattern of functional connectivity. Howeve...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24894
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journal_title:Human brain mapping
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journal_title:Human brain mapping
pub_type: 临床试验,杂志文章
doi:
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abstract::Electrophysiological and neuroimaging studies suggest that the integrity of ipsilesional and inter-hemispheric motor circuits is important for motor recovery after stroke. However, the extent to which each of these tracts contributes to the variance in outcome remains unclear. We examined whether diffusion tensor imag...
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abstract:OBJECTIVES:Memory impairment is one of the most prominent cognitive deficits in temporal lobe epilepsy (TLE). The overall goal of this study was to explore the contribution of cortical and hippocampal (subfield) damage to impairment of auditory immediate recall (AIMrecall), auditory delayed recall (ADMrecall), and audi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21226
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journal_title:Human brain mapping
pub_type: 杂志文章
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doi:10.1002/hbm.22467
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22768
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doi:10.1002/hbm.24634
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20858
更新日期:2010-02-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21114
更新日期:2011-09-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23403
更新日期:2017-01-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24836
更新日期:2020-02-15 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20409
更新日期:2008-04-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21396
更新日期:2012-11-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22648
更新日期:2015-02-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24319
更新日期:2018-12-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22073
更新日期:2013-10-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24826
更新日期:2020-02-15 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
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更新日期:2011-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20261
更新日期:2007-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-11-17 00:00:00
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pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22129
更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20922
更新日期:2010-07-01 00:00:00
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journal_title:Human brain mapping
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