Abstract:
:Carpal tunnel syndrome (CTS) is a common entrapment neuropathy of the median nerve characterized by paresthesias and pain in the first through fourth digits. We hypothesize that aberrant afferent input from CTS will lead to maladaptive cortical plasticity, which may be corrected by appropriate therapy. Functional MRI (fMRI) scanning and clinical testing was performed on CTS patients at baseline and after 5 weeks of acupuncture treatment. As a control, healthy adults were also tested 5 weeks apart. During fMRI, sensory stimulation was performed for median nerve innervated digit 2 (D2) and digit 3 (D3), and ulnar nerve innervated digit 5 (D5). Surface-based and region of interest (ROI)-based analyses demonstrated that while the extent of fMRI activity in contralateral Brodmann Area 1 (BA 1) and BA 4 was increased in CTS compared to healthy adults, after acupuncture there was a significant decrease in contralateral BA 1 (P < 0.005) and BA 4 (P < 0.05) activity during D3 sensory stimulation. Healthy adults demonstrated no significant test-retest differences for any digit tested. While D3/D2 separation was contracted or blurred in CTS patients compared to healthy adults, the D2 SI representation shifted laterally after acupuncture treatment, leading to increased D3/D2 separation. Increasing D3/D2 separation correlated with decreasing paresthesias in CTS patients (P < 0.05). As CTS-induced paresthesias constitute diffuse, synchronized, multidigit symptomatology, our results for maladaptive change and correction are consistent with Hebbian plasticity mechanisms. Acupuncture, a somatosensory conditioning stimulus, shows promise in inducing beneficial cortical plasticity manifested by more focused digital representations.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Napadow V,Liu J,Li M,Kettner N,Ryan A,Kwong KK,Hui KK,Audette JFdoi
10.1002/hbm.20261subject
Has Abstractpub_date
2007-03-01 00:00:00pages
159-71issue
3eissn
1065-9471issn
1097-0193journal_volume
28pub_type
杂志文章abstract::Previous studies have led to the proposal that patients with Alzheimer's disease (AD) may have disturbed functional connectivity between different brain regions. Furthermore, recent resting-state functional magnetic resonance imaging (fMRI) studies have also shown that low-frequency (<0.08 Hz) fluctuations (LFF) of th...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20324
更新日期:2007-10-01 00:00:00
abstract::The goal of this study was to document current clinical practice and report patient outcomes in presurgical language functional MRI (fMRI) for epilepsy surgery. Epilepsy surgical programs worldwide were surveyed as to the utility, implementation, and efficacy of language fMRI in the clinic; 82 programs responded. Resp...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24039
更新日期:2018-07-01 00:00:00
abstract::We investigated brain responses to matching versus nonmatching objects in working memory (WM) with a modified delayed match-to-sample task using event-related potentials (ERPs). In addition, ERP correlates of new items (new matches/new nonmatches) and previously studied items (studied matches/studied nonmatches) were ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20409
更新日期:2008-04-01 00:00:00
abstract::It has previously been demonstrated that there is a negative correlation between the amplitude of the BOLD response and resting γ amino-butyric acid (GABA) concentration in visual cortex. The work here is the first to empirically characterize individual variability in the haemodynamic response functions (HRFs) in resp...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21223
更新日期:2012-02-01 00:00:00
abstract::The orbitofrontal cortex (OFC)-amygdala circuit is critical to goal-directed behavior, learning, and valuation. However, our understanding of the OFC-amygdala connections that support these emergent processes is hampered by our reliance on the primate literature and insufficient knowledge regarding the connectivity pa...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25300
更新日期:2020-12-03 00:00:00
abstract::We describe a functional neuroanatomy approach that combines structural (MRI) and functional (PET) data at the individual level. For each subject MRI dataset, sulci are first localized using hemisphere surface rendering and sections and stored. Using these landmarks, the subject brain volume is then divided in 100 ana...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1997)5:4<228::AID-HBM4>3.0
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Cognitive dysfunction is considered a core feature of schizophrenia, and impaired performances in episodic memory (EM) and executive function (EF) tasks are consistently reported in schizophrenia patients. Traditional fMRI and EEG studies have helped identifying brain areas, including the prefrontal cortex (...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22935
更新日期:2015-11-01 00:00:00
abstract::Incongruent auditory and visual stimuli can elicit audiovisual illusions such as the McGurk effect where visual /ka/ and auditory /pa/ fuse into another percept such as/ta/. In the present study, human brain activity was measured with adaptation functional magnetic resonance imaging to investigate which brain areas su...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20884
更新日期:2010-04-01 00:00:00
abstract::Previous research in young adults has demonstrated that both motor learning and transcranial direct current stimulation (tDCS) trigger decreases in the levels of gamma-aminobutyric acid (GABA) in the sensorimotor cortex, and these decreases are linked to greater learning. Less is known about the role of GABA in motor ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25041
更新日期:2020-09-01 00:00:00
abstract::We systematically investigated the effects of cathodal and anodal Transcranial Direct Current Stimulation (CtDCS, AtDCS) on the electric activity of primary motor cortex during a motor task. High-density electroencephalography was used to define the spatial diffusion of tDCS after effects. Ten healthy subjects perform...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22322
更新日期:2014-05-01 00:00:00
abstract::General cognitive ability (GCA) refers to a trait-like ability that contributes to performance across diverse cognitive tasks. Identifying brain-based markers of GCA has been a longstanding goal of cognitive and clinical neuroscience. Recently, predictive modeling methods have emerged that build whole-brain, distribut...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25007
更新日期:2020-08-15 00:00:00
abstract::Transcranial magnetic stimulation (TMS) during positron emission tomography (PET) is a novel technique for in vivo measurements of connectivity and excitability of the human cerebral cortex. Here we describe tools that allow investigators to position the stimulating coil over a target region and to verify the actual p...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
abstract::The theory of material specific lateralization of memory function posits that left and right MTL regions are asymmetrically involved in mnemonic processing of verbal and nonverbal material respectively. Lesion and functional imaging (fMRI) studies provide robust evidence for a left MTL asymmetry in the verbal memory d...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23077
更新日期:2016-03-01 00:00:00
abstract::The relationship between neocortical structure and function is a key area of research in neuroscience. Most studies of neural function, whether using neurophysiology or neuroimaging methods, are interpreted with relation to the underlying cortical myelo- and cytoarchitecture. For functional neuroimaging studies this o...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20162
更新日期:2005-12-01 00:00:00
abstract::Recently, it has been suggested that backwardly masked, and thus subliminally presented, fearful eyes are processed by the amygdala. Here, we investigated in four functional magnetic resonance imaging experiments whether the amygdala responds to subliminally presented fearful eyes per se or whether an interaction of m...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20960
更新日期:2010-10-01 00:00:00
abstract::What basic visual structures underlie human face detection and how can we extract such structures directly from the amplitude of neural responses elicited by face processing? Here, we address these issues by investigating an extension of noise-based image classification to BOLD responses recorded in high-level visual ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22128
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Early life trauma (ELT) is a significant risk factor for the onset of depression. Emerging findings indicate ELT is associated with enhanced amygdala reactivity to aversive stimuli in never-depressed healthy controls as well as those with acute depression but may be absent in non-ELT exposed depressed. The pr...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22514
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Reduced cortical thickness is a candidate biological marker of depression, although findings are inconsistent. This could reflect analytic heterogeneity, such as use of region-wise cortical thickness based on the Freesurfer Desikan-Killiany (DK) atlas or surface-based morphometry (SBM). The Freesurfer Destri...
journal_title:Human brain mapping
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/hbm.23664
更新日期:2017-09-01 00:00:00
abstract::We propose a hardware and software architecture to respond to crucial problems in the neuroimaging field: storage, retrieval, and processing of large datasets. The B-SPID project, here discussed, concerns the processing of neuroimages and attached components stored in an object-relational multimedia database managemen...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(sici)1097-0193(1999)7:2<136::aid-hbm6>3.0
更新日期:1999-01-01 00:00:00
abstract::The human brain can be subdivided many ways depending upon the criteria used. One of the most basic approaches is to subdivide the cortical regions into functional units composed of the frontal, occipital, parietal, and temporal lobes. To date, the process of reliably extracting measurements of the human brain from MR...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1997)5:5<355::AID-HBM4>3.0
更新日期:1997-01-01 00:00:00
abstract::The luminance contrast of a visual stimulus is known to modulate the response properties of areas V1 and the human MT complex (hMT+), but has not been shown to modulate interactions between these two areas. We examined the direction of information transfer between V1/V2 and hMT+ at different stimulus contrasts by meas...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20495
更新日期:2009-01-01 00:00:00
abstract::A set of cortical and sub-cortical brain structures has been linked with sentence-level semantic processes. However, it remains unclear how these brain regions are organized to support the semantic integration of a word into sentential context. To look into this issue, we conducted a functional magnetic resonance imag...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22182
更新日期:2014-02-01 00:00:00
abstract::Adolescence is a time period associated with marked brain maturation that coincides with an enhanced risk for onset of psychiatric disorder. White matter tract myelination, a process that continues to unfold throughout adolescence, is reported to be abnormal in several psychiatric disorders. Here, we ask whether psych...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24842
更新日期:2020-02-15 00:00:00
abstract::In social interactions, humans are expected to regulate interpersonal distance in response to the emotion displayed by others. Yet, the neural mechanisms implicated in approach-avoidance tendencies to distinct emotional expressions have not been fully described. Here, we investigated the neural systems implicated in r...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23467
更新日期:2017-03-01 00:00:00
abstract::An important function of the brain's orienting response is to enable the evaluation of novel, environmental events in order to prepare for potential behavioral action. Here, we assessed the event-related hemodynamic (erfMRI) correlates of this phenomenon using unexpected (i.e., novel) environmental sounds presented wi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20587
更新日期:2009-04-01 00:00:00
abstract::There has been a recent call for longitudinal imaging studies to better characterize the time course of physiological recovery following sport-related concussion (SRC) and its relationship with clinical recovery. To address this, we evaluated changes to resting-state functional connectivity (rs-FC) of the whole-brain ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24440
更新日期:2019-03-01 00:00:00
abstract::To test a prediction of our previous computational model of cortico-hippocampal interaction (Gluck and Myers [1993, 2001]) for characterizing individual differences in category learning, we studied young healthy subjects using an fMRI-adapted category-learning task that has two phases, an initial phase in which associ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22389
更新日期:2014-07-01 00:00:00
abstract::In daily life, we permanently need to adapt our behavior to new task situations, requiring cognitive control. Such adaptive processes are commonly investigated with the task-switching paradigm. Many fMRI studies have interpreted stronger activation for switch than repeat trials in fronto-parietal brain areas as reflec...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21234
更新日期:2012-03-01 00:00:00
abstract::Dopaminergic degeneration is a hallmark of Parkinson's disease (PD), which causes various symptoms affected by corticostriatal circuits. So far, the relationship between cortical changes and dopamine loss in the striatum is unclear. Here, we evaluate the gray matter (GM) changes in accordance with striatal dopaminergi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23130
更新日期:2016-05-01 00:00:00
abstract::In contrast to conventional functional magnetic resonance imaging (fMRI) analysis across participants, item analysis allows generalizing the observed neural response patterns from a specific stimulus set to the entire population of stimuli. In the present study, we perform an item analysis on an fMRI paradigm (EmpaToM...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24966
更新日期:2020-07-01 00:00:00