Anxiety positive subjects show altered processing in the anterior insula during anticipation of negative stimuli.

Abstract:

:Prior neuroimaging studies support the hypothesis that anticipation, an important component of anxiety, may be mediated by activation within the insular and medial prefrontal cortices including the anterior cingulate cortex. However, there is an insufficient understanding of how affective anticipation differs across anxiety groups in emotional brain loci and networks. We examined 14 anxiety positive (AP) and 14 anxiety normative (AN) individuals completing an affective picture anticipation task during functional magnetic resonance imaging (fMRI). Brain activation was examined across groups for cued anticipation (to aversive or pleasant stimuli). Both groups showed greater activation in the bilateral anterior insula during cued differential anticipation (i.e., aversive vs. pleasant), and activation on the right was significantly higher in AP compared to AN subjects. Functional connectivity showed that the left anterior insula was involved in a similar network during pleasant anticipation in both groups. The left anterior insula during aversive and the right anterior insula during all anticipation conditions coactivated with a cortical network consisting of frontal and parietal lobes in the AP group to a greater degree. These results are consistent with the hypothesis that anxiety is related to greater anticipatory reactivity in the brain and that there may be functional asymmetries in the brain that interact with psychiatric traits.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Simmons AN,Stein MB,Strigo IA,Arce E,Hitchcock C,Paulus MP

doi

10.1002/hbm.21154

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

1836-46

issue

11

eissn

1065-9471

issn

1097-0193

journal_volume

32

pub_type

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