Abstract:
:To test a prediction of our previous computational model of cortico-hippocampal interaction (Gluck and Myers [1993, 2001]) for characterizing individual differences in category learning, we studied young healthy subjects using an fMRI-adapted category-learning task that has two phases, an initial phase in which associations are learned through trial-and-error feedback followed by a generalization phase in which previously learned rules can be applied to novel associations (Myers et al. [2003]). As expected by our model, we found a negative correlation between learning-related hippocampal responses and accuracy during transfer, demonstrating that hippocampal adaptation during learning is associated with better behavioral scores during transfer generalization. In addition, we found an inverse relationship between Blood Oxygenation Level Dependent (BOLD) activity in the striatum and that in the hippocampal formation and the orbitofrontal cortex during the initial learning phase. Conversely, activity in the dorsolateral prefrontal cortex, orbitofrontal cortex and parietal lobes dominated over that of the hippocampal formation during the generalization phase. These findings provide evidence in support of theories of the neural substrates of category learning which argue that the hippocampal region plays a critical role during learning for appropriately encoding and representing newly learned information so that that this learning can be successfully applied and generalized to subsequent novel task demands.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Fera F,Passamonti L,Herzallah MM,Myers CE,Veltri P,Morganti G,Quattrone A,Gluck MAdoi
10.1002/hbm.22389subject
Has Abstractpub_date
2014-07-01 00:00:00pages
3122-31issue
7eissn
1065-9471issn
1097-0193journal_volume
35pub_type
杂志文章abstract:PURPOSE:To investigate the intrinsic brain connections at the time of interictal generalized spike-wave discharges (GSWDs) to understand their mechanism of effect on brain function in untreated childhood absence epilepsy (CAE). METHODS:The EEG-functional MRI (fMRI) was used to measure the resting state functional conn...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22025
更新日期:2013-08-01 00:00:00
abstract::We systematically investigated the effects of cathodal and anodal Transcranial Direct Current Stimulation (CtDCS, AtDCS) on the electric activity of primary motor cortex during a motor task. High-density electroencephalography was used to define the spatial diffusion of tDCS after effects. Ten healthy subjects perform...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22322
更新日期:2014-05-01 00:00:00
abstract::Previous studies have led to the proposal that patients with Alzheimer's disease (AD) may have disturbed functional connectivity between different brain regions. Furthermore, recent resting-state functional magnetic resonance imaging (fMRI) studies have also shown that low-frequency (<0.08 Hz) fluctuations (LFF) of th...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20324
更新日期:2007-10-01 00:00:00
abstract::The preprocessing pipelines typically used in both task and resting-state functional magnetic resonance imaging (rs-fMRI) analysis are modular in nature: They are composed of a number of separate filtering/regression steps, including removal of head motion covariates and band-pass filtering, performed sequentially and...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24528
更新日期:2019-06-01 00:00:00
abstract::We present an overview of the types of imaging experiments that can be performed on psychologically impaired patients. The critical observation from such studies is a differential pattern of activation in the patients and normals. Underactivity is interpretable only when the patients make normal responses. In this con...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0193(1999)8:2/3<102::aid-hbm6>3
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Reduced cortical thickness is a candidate biological marker of depression, although findings are inconsistent. This could reflect analytic heterogeneity, such as use of region-wise cortical thickness based on the Freesurfer Desikan-Killiany (DK) atlas or surface-based morphometry (SBM). The Freesurfer Destri...
journal_title:Human brain mapping
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/hbm.23664
更新日期:2017-09-01 00:00:00
abstract::It has recently been demonstrated that specific patterns of correlation exist in diffusion tensor imaging (DTI) parameters across white matter tracts in the normal human brain. These microstructural correlations are thought to reflect phylogenetic and functional similarities between different axonal fiber pathways. Ho...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21292
更新日期:2012-06-01 00:00:00
abstract::Classical delay eyeblink conditioning is likely the most commonly used paradigm to study cerebellar learning. As yet, few studies have focused on extinction and savings of conditioned eyeblink responses (CRs). Saving effects, which are reflected in a reacquisition after extinction that is faster than the initial acqui...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23641
更新日期:2017-08-01 00:00:00
abstract::The hippocampus, a hub of activity for a variety of important cognitive processes, is a target of increasing interest for researchers and clinicians. Magnetoencephalography (MEG) is an attractive technique for imaging spectro-temporal aspects of function, for example, neural oscillations and network timing, especially...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24445
更新日期:2019-03-01 00:00:00
abstract::The relationship between neocortical structure and function is a key area of research in neuroscience. Most studies of neural function, whether using neurophysiology or neuroimaging methods, are interpreted with relation to the underlying cortical myelo- and cytoarchitecture. For functional neuroimaging studies this o...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20162
更新日期:2005-12-01 00:00:00
abstract::Gyrification brain abnormalities are considered a marker of early deviations from normal developmental trajectories and a putative predictor of poor outcome in psychiatric disorders. The aim of this study was to explore cortical folding morphology in patients with anorexia nervosa (AN). A MRI brain study was conducted...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22998
更新日期:2015-12-01 00:00:00
abstract::Metabolic markers of baseline brain oxygenation and tissue perfusion have an important role to play in the early identification of ischaemic tissue in acute stroke. Although well established MRI techniques exist for mapping brain perfusion, quantitative imaging of brain oxygenation is poorly served. Streamlined-qBOLD ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24564
更新日期:2019-07-01 00:00:00
abstract::Imagination and creative cognition are often associated with the brain's default network (DN). Recent evidence has also linked cognitive control systems to performance on tasks involving imagination and creativity, with a growing number of studies reporting functional interactions between cognitive control and DN regi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23884
更新日期:2018-02-01 00:00:00
abstract::How the human brain represents distinct motor features into a unique finalized action still remains undefined. Previous models proposed the distinct features of a motor act to be hierarchically organized in separated, but functionally interconnected, cortical areas. Here, we hypothesized that distinct patterns across ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22881
更新日期:2015-10-01 00:00:00
abstract::Electrophysiological signals from the cerebellum have traditionally been viewed as inaccessible to magnetoencephalography (MEG) and electroencephalography (EEG). Here, we challenge this position by investigating the ability of MEG and EEG to detect cerebellar activity using a model that employs a high-resolution tesse...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24951
更新日期:2020-06-15 00:00:00
abstract::Three decades ago a series of parallel circuits were described involving the frontal cortex and deep grey matter structures, with putative roles in control of motor and oculomotor function, cognition, behaviour and emotion. The circuit comprising the dorsolateral prefrontal cortex, caudate, globus pallidus and thalamu...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25239
更新日期:2020-10-19 00:00:00
abstract::The human brain can be subdivided many ways depending upon the criteria used. One of the most basic approaches is to subdivide the cortical regions into functional units composed of the frontal, occipital, parietal, and temporal lobes. To date, the process of reliably extracting measurements of the human brain from MR...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1997)5:5<355::AID-HBM4>3.0
更新日期:1997-01-01 00:00:00
abstract::The TREK1 gene has been linked to a depression-resistant phenotype in rodents and antidepressant response in humans, but the neural mechanisms underlying these links are unclear. Because TREK1 is expressed in reward-related basal ganglia regions, it has been hypothesized that TREK1 genetic variation may be associated ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20858
更新日期:2010-02-01 00:00:00
abstract::Although elevated serum high-sensitivity C-reactive protein (hsCRP) is related to atherosclerosis, brain infarction, and cognitive decline, it has not been clarified whether increased hsCRP is associated with the decline in brain gray matter volume. Therefore, the purpose of this study was to determine the relationshi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22073
更新日期:2013-10-01 00:00:00
abstract::Active motor functional magnetic resonance imaging (fMRI) studies have shown that pediatric multiple sclerosis (MS) patients have a strictly lateralized pattern of activations and a preserved functional connectivity (FC) within the motor system when compared to age-matched healthy controls. However, it is still not cl...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22469
更新日期:2014-08-01 00:00:00
abstract::Diffusion-weighted magnetic resonance imaging allows researchers and clinicians to identify individual white matter fiber tracts and map their trajectories. The reliability and interpretability of fiber-tracking procedures is improved when a priori anatomical information is used as a guide. We have developed an automa...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20619
更新日期:2009-05-01 00:00:00
abstract::Neuroimaging studies in humans have consistently found robust activation of frontal, parietal, and temporal regions during working memory tasks. Whether these activations represent functional networks segregated by perceptual domain is still at issue. Two functional magnetic resonance imaging experiments were conducte...
journal_title:Human brain mapping
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1998-01-01 00:00:00
abstract::The neural basis of the automatic activation of words was investigated in an fMRI study. In the study, words were presented briefly (51 or 151 msec) followed by a mask. To prevent attentional processing, subjects attended to the masks and not the words, and were required to make perceptual judgment about the masks. We...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.10096
更新日期:2003-03-01 00:00:00
abstract::The anterior limb of the internal capsule (ALIC) is an important locus of frontal-subcortical fiber tracts involved in cognitive and limbic feedback loops. However, the structural organization of its component fiber tracts remains unclear. Therefore, although the ALIC is a promising target for various neurosurgical pr...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23815
更新日期:2017-12-01 00:00:00
abstract::Current knowledge about small-world networks underlying emotions is sparse, and confined to functional magnetic resonance imaging (fMRI) studies using resting-state paradigms. This fMRI study applied Eigenvector Centrality Mapping (ECM) and functional connectivity analysis to reveal neural small-world networks underly...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22416
更新日期:2014-07-01 00:00:00
abstract::Maintaining alertness is critical for safe and successful performance of most human activities. Consequently, microsleeps during continuous visuomotor tasks, such as driving, can be very serious, not only disrupting performance but sometimes leading to injury or death due to accidents. We have investigated the neural ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22178
更新日期:2014-01-01 00:00:00
abstract::Mental calculation is a complex mental procedure involving a frontoparietal network of brain regions. Functional MRI (fMRI) studies have revealed interesting characteristics of these regions, but the precise function of some areas remains elusive. In the present study, we used electrocorticographic (ECoG) recordings t...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22593
更新日期:2014-12-01 00:00:00
abstract::Developmental dyslexia affects 40-60% of children with a familial risk (FHD+) compared to a general prevalence of 5-10%. Despite the increased risk, about half of FHD+ children develop typical reading abilities (FHD+Typical). Yet the underlying neural characteristics of favorable reading outcomes in at-risk children r...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24980
更新日期:2020-07-01 00:00:00
abstract::Lesion studies on nonhuman primates utilizing recognition memory tests have shown that the orbitofrontal cortex is critical for the encoding of novel information, and anatomical studies have shown that the orbitofrontal cortex forms part of a mnemonic circuit that connects limbic medial temporal areas with higher-orde...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20532
更新日期:2009-02-01 00:00:00
abstract::Glucose transporter type I deficiency syndrome (GLUT1DS) is an encephalopathic disorder due to a chronic insufficient transport of glucose into the brain. PET studies in GLUT1DS documented a widespread cortico-thalamic hypometabolism and a signal increase in the basal ganglia, regardless of age and clinical phenotype....
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24815
更新日期:2020-02-01 00:00:00