Abstract:
OBJECTIVES:Recovery of independent ambulation after stroke is a major goal. However, which rehabilitation regimen best benefits each individual is unknown and decisions are currently made on a subjective basis. Predictors of response to specific therapies would guide the type of therapy most appropriate for each patient. Although lesion topography is a strong predictor of upper limb response, walking involves more distributed functions. Earlier studies that assessed the cortico-spinal tract (CST) were negative, suggesting other structures may be important. EXPERIMENTAL DESIGN:The relationship between lesion topography and response of walking speed to standard rehabilitation was assessed in 50 adult-onset patients using both volumetric measurement of CST lesion load and voxel-based lesion-symptom mapping (VLSM) to assess non-CST structures. Two functional mobility scales, the functional ambulation category (FAC) and the modified rivermead mobility index (MRMI) were also administered. Performance measures were obtained both at entry into the study (3-42 days post-stroke) and at the end of a 6-week course of therapy. Baseline score, age, time since stroke onset and white matter hyperintensities score were included as nuisance covariates in regression models. PRINCIPAL OBSERVATIONS:CST damage independently predicted response to therapy for FAC and MRMI, but not for walk speed. However, using VLSM the latter was predicted by damage to the putamen, insula, external capsule and neighbouring white matter. CONCLUSIONS:Walk speed response to rehabilitation was affected by damage involving the putamen and neighbouring structures but not the CST, while the latter had modest but significant impact on everyday functions of general mobility and gait. Hum Brain Mapp 37:689-703, 2016. © 2015 Wiley Periodicals, Inc.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Jones PS,Pomeroy VM,Wang J,Schlaug G,Tulasi Marrapu S,Geva S,Rowe PJ,Chandler E,Kerr A,Baron JC,SWIFT-Cast investigators.doi
10.1002/hbm.23059subject
Has Abstractpub_date
2016-02-01 00:00:00pages
689-703issue
2eissn
1065-9471issn
1097-0193journal_volume
37pub_type
杂志文章,随机对照试验abstract::Although memory dysfunction is not a prominent feature of the behavioral variant of frontotemporal dementia (bv-FTD), there is evidence of specific deficits of episodic memory in these patients. They also have problems monitoring their memory performance. The objective of the present study was to explore the ability t...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21282
更新日期:2012-06-01 00:00:00
abstract::Neuroimaging research examining correlates of adolescent behavioral maturation has focused largely on issues related to higher cognitive development. Currently few studies have explored neural correlates of emotional reactivity in adolescent groups. In this study, we sought to examine the nature of posterior cingulate...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20436
更新日期:2008-08-01 00:00:00
abstract::Developmental dyslexia affects 40-60% of children with a familial risk (FHD+) compared to a general prevalence of 5-10%. Despite the increased risk, about half of FHD+ children develop typical reading abilities (FHD+Typical). Yet the underlying neural characteristics of favorable reading outcomes in at-risk children r...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24980
更新日期:2020-07-01 00:00:00
abstract::Research using the Stop Signal Task employing an adaptive algorithm to accommodate individual differences often report inferior performance on the task in individuals with ADHD, OCD, and substance use disorders compared to non-clinical controls. Furthermore, individuals with deficits in inhibitory control tend to show...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24075
更新日期:2018-08-01 00:00:00
abstract::This paper describes a Bayesian method for three-dimensional registration of brain images. A finite element approach is used to obtain a maximum a posteriori estimate of the deformation field at every voxel of a template volume. The priors used by the MAP estimate penalize unlikely deformations and enforce a continuou...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(sici)1097-0193(200004)9:4<212::aid-hbm3>3
更新日期:2000-04-01 00:00:00
abstract::There is still no clear consensus as to which of the many functional and structural changes in the brain in schizophrenia are of most importance, although the main focus to date has been on those in the frontal and cingulate cortices. In the present study, we have used a novel holistic approach to identify brain-wide ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22162
更新日期:2014-01-01 00:00:00
abstract::The reproducibility of activation patterns in the whole brain obtained by functional magnetic resonance imaging (fMRI) experiments at 4 Tesla was studied with a simple finger-opposition task. Six subjects performed three runs in one session, and each run was analyzed separately with the t-test as a univariate method a...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(sici)1097-0193(1999)7:4<267::aid-hbm5>3.0
更新日期:1999-01-01 00:00:00
abstract::This fMRI study investigated brain activity while soccer players were imagining creative moves in real soccer decision-making situations. After presenting brief video clips of a soccer scene, participants had to imagine themselves as the acting player and think either of a creative or obvious move that might lead to a...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24408
更新日期:2019-02-15 00:00:00
abstract::Free water elimination (FWE) in brain diffusion MRI has been shown to improve tissue specificity in human white matter characterization both in health and in disease. Relative to the classical diffusion tensor imaging (DTI) model, FWE is also expected to increase sensitivity to microstructural changes in longitudinal ...
journal_title:Human brain mapping
pub_type: 杂志文章,多中心研究
doi:10.1002/hbm.23350
更新日期:2017-01-01 00:00:00
abstract::Playing music requires a strong coupling of perception and action mediated by multimodal integration of brain regions, which can be described as network connections measured by anatomical and functional correlations between regions. However, the structural and functional connectivities within and between the auditory ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23989
更新日期:2018-05-01 00:00:00
abstract::The mirror neuron system (MNS) is considered crucial for human imitation and language learning and provides the basis for the development of empathy and mentalizing. Alexithymia (ALEX), which refers to deficiencies in the self-awareness of emotional states, has been reported to be associated with poor ability in vario...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20653
更新日期:2009-07-01 00:00:00
abstract::Functional connectivity analysis of brain networks has become an important tool for investigation of human brain function. Although functional connectivity computations are usually based on resting-state data, the application to task-specific fMRI has received growing attention. Three major methods for extraction of r...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22897
更新日期:2015-10-01 00:00:00
abstract:UNLABELLED:Major depression has been repeatedly associated with amygdala hyper-responsiveness to negative (but not positive) facial expressions at early, automatic stages of emotion processing using subliminally presented stimuli. However, it is not clear whether this "limbic bias" is a correlate of depression or repre...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22112
更新日期:2013-11-01 00:00:00
abstract::Very preterm born (VPT) children are those born before 32/40 weeks' gestational age and comprise 10% of the 15 million babies born prematurely worldwide each year. Due to advancements in neonatal medicine, the survival rate of VPT birth has increased, but few studies have investigated the nonmedical, social-cognitive ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25088
更新日期:2020-09-01 00:00:00
abstract::A persistent problem in developing plausible neurophysiological models of perception, cognition, and action is the difficulty of characterizing the interactions between different neural systems. Previous studies have approached this problem by estimating causal influences across brain areas activated during cognitive ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20772
更新日期:2009-06-01 00:00:00
abstract::Cognitive deficits are common in Parkinson's disease and we suspect that dysfunctions of connected brain regions can be the source of these deficits. The aim of the present study was to investigate changes in whole-brain intrinsic functional connectivity according to differences in cognitive profiles in Parkinson's di...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23474
更新日期:2017-03-01 00:00:00
abstract::Studies of cognitive function that compare the blood oxygenation level dependent (BOLD) signal across age groups often require the assumption that neurovascular coupling does not change with age. Tests of this assumption have produced mixed results regarding the strength of the coupling and its relative time course. U...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23608
更新日期:2017-07-01 00:00:00
abstract::Although much has been learned about the functional organization of the human brain through lesion-deficit analysis, the variety of statistical and image-processing methods developed for this purpose precludes a closed-form analysis of the statistical power of these systems. Therefore, we developed a lesion-deficit si...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(sici)1097-0193(200006)10:2<61::aid-hbm20>
更新日期:2000-06-01 00:00:00
abstract::Bimanual movements involve the interactions between both primary motor cortices. These interactions are assumed to involve phase-locked oscillatory brain activity referred to as inter-hemispheric functional coupling. So far, inter-hemispheric functional coupling has been investigated as a function of motor performance...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23663
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:While acceleration in age-related cerebral atrophy has been well documented in Alzheimer's disease, the cerebellar contributions to this effect have not been thoroughly investigated. OBJECTIVE:This study investigated cerebellar volume and atrophy rate using magnetic resonance imaging in individuals with nor...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23580
更新日期:2017-06-01 00:00:00
abstract::There has been a recent call for longitudinal imaging studies to better characterize the time course of physiological recovery following sport-related concussion (SRC) and its relationship with clinical recovery. To address this, we evaluated changes to resting-state functional connectivity (rs-FC) of the whole-brain ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24440
更新日期:2019-03-01 00:00:00
abstract::A theoretical framework supporting experimental measures of dynamic properties of human EEG is proposed with emphasis on distinct alpha rhythms. Robust relationships between measured dynamics and cognitive or behavioral conditions are reviewed, and proposed physiological bases for EEG at cellular levels are considered...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.1030
更新日期:2001-07-01 00:00:00
abstract::Carpal tunnel syndrome (CTS) is a common entrapment neuropathy of the median nerve characterized by paresthesias and pain in the first through fourth digits. We hypothesize that aberrant afferent input from CTS will lead to maladaptive cortical plasticity, which may be corrected by appropriate therapy. Functional MRI ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20261
更新日期:2007-03-01 00:00:00
abstract::Electrophysiological signals recorded intracranially show rich frequency content spanning from near-DC to hundreds of hertz. Noninvasive electromagnetic signals measured with electroencephalography (EEG) or magnetoencephalography (MEG) typically contain less signal power in high frequencies than invasive recordings. P...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24795
更新日期:2020-01-01 00:00:00
abstract::Cortical hubs play a fundamental role in the functional architecture of brain connectivity at rest. However, the anatomical scaffold underlying their centrality is still under debate. Certainly, the brain function and anatomy are significantly entwined through synaptogenesis and pruning mechanisms that continuously re...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23721
更新日期:2017-10-01 00:00:00
abstract::Brain morphometry based classification from magnetic resonance (MR) acquisitions has been widely investigated in the diagnosis of Alzheimer's disease (AD) and its prodromal stage, i.e., mild cognitive impairment (MCI). In the literature, a morphometric representation of brain structures is obtained by spatial normaliz...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22531
更新日期:2014-10-01 00:00:00
abstract::In daily life, we permanently need to adapt our behavior to new task situations, requiring cognitive control. Such adaptive processes are commonly investigated with the task-switching paradigm. Many fMRI studies have interpreted stronger activation for switch than repeat trials in fronto-parietal brain areas as reflec...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21234
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:Synchronization between distributed rhythms in the brain is commonly assessed by estimating the synchronization strength from simultaneous measurements. This approach, however, does not elucidate the phase dynamics that underlies synchronization. For this, an explicit dynamical model is required. Based on the...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21099
更新日期:2011-07-01 00:00:00
abstract::Transcranial magnetic stimulation (TMS) during positron emission tomography (PET) is a novel technique for in vivo measurements of connectivity and excitability of the human cerebral cortex. Here we describe tools that allow investigators to position the stimulating coil over a target region and to verify the actual p...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
abstract::Neurodegenerative diseases such as Alzheimer's disease (AD) have been recognized to exhibit disease-specific brain vulnerability patterns. Apolipoprotein E (APOE) ɛ4 allele imparts a high genetic risk of developing AD. Whether the APOE ɛ4 allele damages the brain when cognitive functions are still intact is important ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23359
更新日期:2017-01-01 00:00:00