Abstract:
:The reproducibility of activation patterns in the whole brain obtained by functional magnetic resonance imaging (fMRI) experiments at 4 Tesla was studied with a simple finger-opposition task. Six subjects performed three runs in one session, and each run was analyzed separately with the t-test as a univariate method and Fisher's linear discriminant analysis as a multivariate method. Detrending with a first- and third-order polynomial as well as logarithmic transformation as preprocessing steps for the t-test were tested for their impact on reproducibility. Reproducibility across the whole brain was studied by using scatter plots of statistical values and calculating the correlation coefficient between pairs of activation maps. In order to compare reproducibility of "activated" voxels across runs, subjects and models, 2% of all voxels in the brain with the highest statistical values were classified as activated. The analysis of reproducible activated voxels was performed for the whole brain and within regions of interest. We found considerable variability in reproducibility across subjects, regions of interest, and analysis methods. The t-test on the linear detrended data yielded better reproducibility than Fisher's linear discriminant analysis, and therefore seems to be a robust although conservative method. Preliminary data indicate that these modeling results may be reversed by preprocessing to reduce respiratory and cardiac physiological noise effects. The reproducibility of both the position and number of activated voxels in the sensorimotor cortex was highest, while that of the supplementary motor area was much lower, with reproducibility of the cerebellum falling in between the other two areas.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Tegeler C,Strother SC,Anderson JR,Kim SGdoi
10.1002/(sici)1097-0193(1999)7:4<267::aid-hbm5>3.0keywords:
subject
Has Abstractpub_date
1999-01-01 00:00:00pages
267-83issue
4eissn
1065-9471issn
1097-0193pii
10.1002/(SICI)1097-0193(1999)7:4<267::AID-HBM5>3.0journal_volume
7pub_type
杂志文章abstract::One of the functions of emotional vocalizations is the regulation of social relationships like those between adults and children. Listening to infant vocalizations is known to engage amygdala as well as anterior and posterior cingulate cortices. But, the functional relationships between these structures still need fur...
journal_title:Human brain mapping
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pub_type: 杂志文章,随机对照试验
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