Abstract:
:A thorough understanding of sex differences that exist in the brains of healthy individuals is crucial for the study of neurological illnesses that exhibit phenotypic differences between males and females. Here we evaluate sex differences in regional temporal dependence of resting-state brain activity in 195 adult male-female pairs strictly matched for total grey matter volume from the Human Connectome Project. We find that males have more persistent temporal dependence in regions within temporal, parietal, and occipital cortices. Machine learning algorithms trained on regional temporal dependence measures achieve sex classification accuracies up to 81%. Regions with the strongest feature importance in the sex classification task included cerebellum, amygdala, and frontal and occipital cortices. Secondarily, we show that even after strict matching of total gray matter volume, significant volumetric sex differences persist; males have larger absolute cerebella, hippocampi, parahippocampi, thalami, caudates, and amygdalae while females have larger absolute cingulates, precunei, and frontal and parietal cortices. Sex classification based on regional volume achieves accuracies up to 85%, highlighting the importance of strict volume-matching when studying brain-based sex differences. Differential patterns in regional temporal dependence between the sexes identifies a potential neurobiological substrate or environmental effect underlying sex differences in functional brain activation patterns.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Dhamala E,Jamison KW,Sabuncu MR,Kuceyeski Adoi
10.1002/hbm.25030subject
Has Abstractpub_date
2020-09-01 00:00:00pages
3567-3579issue
13eissn
1065-9471issn
1097-0193journal_volume
41pub_type
杂志文章abstract::Neural dynamics leading to conscious sensory perception have remained enigmatic in despite of large interest. Human functional magnetic resonance imaging (fMRI) studies have revealed that a co-activation of sensory and frontoparietal areas is crucial for conscious sensory perception in the several second time-scale of...
journal_title:Human brain mapping
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journal_title:Human brain mapping
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22514
更新日期:2014-09-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1002/hbm.24388
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20858
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pub_type: 临床试验,杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23515
更新日期:2017-04-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23130
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1002/hbm.23124
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journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
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