Feeling safe in the plane: neural mechanisms underlying superior action control in airplane pilot trainees--a combined EEG/MRS study.

Abstract:

:In day-to-day life, we need to apply strategies to cascade different actions for efficient unfolding of behavior. While deficits in action cascading are examined extensively, almost nothing is known about the neuronal mechanisms mediating superior performance above the normal level. To examine this question, we investigate action control in airplane pilot trainees. We use a stop-change paradigm that is able to estimate the efficiency of action cascading on the basis of mathematical constraints. Behavioral and EEG data is analyzed along these constraints and integrated with neurochemical data obtained using Magnetic Resonance Spectroscopy (MRS) from the striatal gamma-aminobutyric acid (GABA) -ergic system. We show that high performance in action cascading, as exemplified in airplane pilot trainees, can be driven by intensified attentional processes, circumventing response selection processes. The results indicate that the efficiency of action cascading and hence the speed of responding as well as attentional gating functions are modulated by striatal GABA and Glutamate + Glutamine concentrations. In superior performance in action cascading similar increases in the concentrations of GABA and Glutamate + Glutamine lead to stronger neurophysiological and behavioral effects as compared to subjects with normal performance in action cascading.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Yildiz A,Quetscher C,Dharmadhikari S,Chmielewski W,Glaubitz B,Schmidt-Wilcke T,Edden R,Dydak U,Beste C

doi

10.1002/hbm.22530

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

5040-5051

issue

10

eissn

1065-9471

issn

1097-0193

journal_volume

35

pub_type

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