Abstract:
:Non-manifesting carriers (NMC) of the G2019S mutation in the LRRK2 gene represent an "at risk" group for future development of Parkinson's disease (PD) and have demonstrated task related fMRI changes. However, resting-state networks have received less research focus, thus this study aimed to assess the integrity of the motor, default mode (DMN), salience (SAL), and dorsal attention (DAN) networks among this unique population by using two different connectivity measures: interregional functional connectivity analysis and Dependency network analysis (DEP NA). Machine learning classification methods were used to distinguish connectivity between the two groups of participants. Forty-four NMC and 41 non-manifesting non-carriers (NMNC) participated in this study; while no behavioral differences on standard questionnaires could be detected, NMC demonstrated lower connectivity measures in the DMN, SAL, and DAN compared to NMNC but not in the motor network. Significant correlations between NMC connectivity measures in the SAL and attention were identified. Machine learning classification separated NMC from NMNC with an accuracy rate above 0.8. Reduced integrity of non-motor networks was detected among NMC of the G2019S mutation in the LRRK2 gene prior to identifiable changes in connectivity of the motor network, indicating significant non-motor cerebral changes among populations "at risk" for future development of PD.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Jacob Y,Rosenberg-Katz K,Gurevich T,Helmich RC,Bloem BR,Orr-Urtreger A,Giladi N,Mirelman A,Hendler T,Thaler Adoi
10.1002/hbm.24543subject
Has Abstractpub_date
2019-06-01 00:00:00pages
2546-2555issue
8eissn
1065-9471issn
1097-0193journal_volume
40pub_type
杂志文章abstract::Social norms have a critical role in everyday decision-making, as frequent interaction with others regulates our behavior. Neuroimaging studies show that social-based and fairness-related decision-making activates an inconsistent set of areas, which sometimes includes the anterior insula, anterior cingulate cortex, an...
journal_title:Human brain mapping
pub_type: 杂志文章,meta分析
doi:10.1002/hbm.23895
更新日期:2018-02-01 00:00:00
abstract::In daily life, we permanently need to adapt our behavior to new task situations, requiring cognitive control. Such adaptive processes are commonly investigated with the task-switching paradigm. Many fMRI studies have interpreted stronger activation for switch than repeat trials in fronto-parietal brain areas as reflec...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21234
更新日期:2012-03-01 00:00:00
abstract::Variability in human behavior related to sex is supported by neuroimaging studies showing differences in brain activation patterns during cognitive task performance. An emerging field is examining the human connectome, including networks of brain regions that are not only temporally-correlated during different task co...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20968
更新日期:2010-11-01 00:00:00
abstract::Hypercoupling of activity in speech-perception-specific brain networks has been proposed to play a role in the generation of auditory-verbal hallucinations (AVHs) in schizophrenia; however, it is unclear whether this hypercoupling extends to nonverbal auditory perception. We investigated this by comparing schizophreni...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23934
更新日期:2018-04-01 00:00:00
abstract::During complex tasks, patterns of functional connectivity differ from those in the resting state. However, what accounts for such differences remains unclear. Brain activity during a task reflects an unknown mixture of spontaneous and task-evoked activities. The difference in functional connectivity between a task sta...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24335
更新日期:2018-12-01 00:00:00
abstract:INTRODUCTION:Cortical thickness mapping is a widely used method for the analysis of neuroanatomical differences between subject groups. We applied power analysis methods over a range of image processing parameters to derive a model that allows researchers to calculate the number of subjects required to ensure a well-po...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22120
更新日期:2013-11-01 00:00:00
abstract::Brain circuits mediate but also constrain experience-induced plasticity and corresponding behavioral changes. Here we tested whether interindividual behavioral differences in learning a challenging new motor skill correlate with variations in brain anatomy. Young, healthy participants were scanned using structural mag...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24704
更新日期:2019-10-15 00:00:00
abstract::In previous work (Penny et al., [2005]: Neuroimage 24:350-362) we have developed a spatially regularised General Linear Model for the analysis of functional magnetic resonance imaging data that allows for the characterisation of regionally specific effects using Posterior Probability Maps (PPMs). In this paper we show...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20327
更新日期:2007-04-01 00:00:00
abstract::The spatial location of an object can be represented in two frames of reference: egocentric (relative to the observer's body or body parts) and allocentric (relative to another object independent of the observer). The object positions relative to the two frames can be either congruent (e.g., both left or both right) o...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23508
更新日期:2017-04-01 00:00:00
abstract::Classically, model-based segmentation procedures match magnetic resonance imaging (MRI) volumes to an expertly labeled atlas using nonlinear registration. The accuracy of these techniques are limited due to atlas biases, misregistration, and resampling error. Multi-atlas-based approaches are used as a remedy and invol...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22092
更新日期:2013-10-01 00:00:00
abstract::Successful response selection relies on constantly updating stimulus-response associations. The Theory of Event Coding (TEC) proposes that perception and action are conjointly coded in event files, for which fronto-striatal networks seem to play an important role. However, the exact neurobiochemical mechanism behind e...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25335
更新日期:2021-01-09 00:00:00
abstract::The anterior limb of the internal capsule (ALIC) is an important locus of frontal-subcortical fiber tracts involved in cognitive and limbic feedback loops. However, the structural organization of its component fiber tracts remains unclear. Therefore, although the ALIC is a promising target for various neurosurgical pr...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23815
更新日期:2017-12-01 00:00:00
abstract::The use of functional magnetic resonance imaging (fMRI) to explore central auditory function may be compromised by the intense bursts of stray acoustic noise produced by the scanner whenever the magnetic resonance signal is read out. We present results evaluating the use of one method to reduce the effect of the scann...
journal_title:Human brain mapping
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0193(1999)7:3<213::aid-hbm5>3.0
更新日期:1999-01-01 00:00:00
abstract::The role of the right hemisphere (RH) in metaphor comprehension is still controversial. Numerous neuroimaging studies have found that conventionality, sentential context, and task demand can influence the involvement of the RH in metaphor processing. The current meta-analysis used foci from 17 original functional magn...
journal_title:Human brain mapping
pub_type: 杂志文章,meta分析
doi:10.1002/hbm.22160
更新日期:2014-01-01 00:00:00
abstract::The relationship between neocortical structure and function is a key area of research in neuroscience. Most studies of neural function, whether using neurophysiology or neuroimaging methods, are interpreted with relation to the underlying cortical myelo- and cytoarchitecture. For functional neuroimaging studies this o...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20162
更新日期:2005-12-01 00:00:00
abstract::Electrophysiological and neuroimaging studies suggest that the integrity of ipsilesional and inter-hemispheric motor circuits is important for motor recovery after stroke. However, the extent to which each of these tracts contributes to the variance in outcome remains unclear. We examined whether diffusion tensor imag...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21266
更新日期:2012-05-01 00:00:00
abstract::The orienting of attention to the spatial location of sensory stimuli in one modality based on sensory stimuli presented in another modality (i.e., cross-modal orienting) is a common mechanism for controlling attentional shifts. The neuronal mechanisms of top-down cross-modal orienting have been studied extensively. H...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22227
更新日期:2014-03-01 00:00:00
abstract::Several studies have shown activation of the mirror neuron system (MNS), comprising the temporal, posterior parietal, and sensorimotor areas when observing plausible actions, but far less is known on how these cortical areas interact during the recognition of a plausible action. Here, we recorded neural activity with ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22207
更新日期:2014-02-01 00:00:00
abstract::Magnetic resonance imaging (MRI) studies of fetal alcohol spectrum disorder (FASD) have shown reductions of brain volume associated with prenatal exposure to alcohol. Previous studies consider regional brain volumes independently but ignore potential relationships across numerous structures. This study aims to (a) ide...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24867
更新日期:2020-04-01 00:00:00
abstract::Working memory (WM) for auditory information has been thought of as a unitary system, but whether WM for verbal and tonal information relies on the same or different functional neuroarchitectures has remained unknown. This fMRI study examines verbal and tonal WM in both nonmusicians (who are trained in speech, but not...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21060
更新日期:2011-05-01 00:00:00
abstract::We present a method for registering a brain in the Talairach coordinate system that can be performed either "online," i.e., in real time while a subject is in a magnetic resonance scanner, or "offline" on a previously acquired three-dimensional (3D) data set. The method is applicable to functional magnetic resonance i...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1997)5:1<58::AID-HBM6>3.0.
更新日期:1997-01-01 00:00:00
abstract::We used computer simulations to investigate finite element models of the layered structure of the human skull in EEG source analysis. Local models, where each skull location was modeled differently, and global models, where the skull was assumed to be homogeneous, were compared to a reference model, in which spongy an...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21114
更新日期:2011-09-01 00:00:00
abstract::It has recently been demonstrated that specific patterns of correlation exist in diffusion tensor imaging (DTI) parameters across white matter tracts in the normal human brain. These microstructural correlations are thought to reflect phylogenetic and functional similarities between different axonal fiber pathways. Ho...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21292
更新日期:2012-06-01 00:00:00
abstract::Multicenter structural MRI studies can have greater statistical power than single-center studies. However, across-center differences in contrast sensitivity, spatial uniformity, etc., may lead to tissue classification or image registration differences that could reduce or wholly offset the enhanced statistical power o...
journal_title:Human brain mapping
pub_type: 杂志文章,多中心研究
doi:10.1002/hbm.20991
更新日期:2010-12-01 00:00:00
abstract::The Stroop interference test requires a person to respond to specific elements of a stimulus while suppressing a competing response. Previous positron emission tomography (PET) work has shown increased activity in the right anterior cingulate gyrus during the Stroop test. It is unclear, however, whether the anterior c...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.460010305
更新日期:1994-01-01 00:00:00
abstract::Habituation is a basic process of learning in which repeated exposure to a sensory stimulus leads to a decrease in the strength of neuronal activations and behavioral responses. In addition to increases in neuronal activity, sensory stimuli can also lead to decreases in neuronal activity. Until now, the effects of hab...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22163
更新日期:2014-01-01 00:00:00
abstract::Transcranial direct current stimulation (tDCS) induces polarity- and dose-dependent neuroplastic aftereffects on cortical excitability and cortical activity, as demonstrated by transcranial magnetic stimulation (TMS) and functional imaging (fMRI) studies. However, lacking systematic comparative studies between stimula...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24901
更新日期:2020-04-15 00:00:00
abstract::Brain plasticity and memory formation depend on the expression of a large number of genes. This relationship had been studied using several experimental approaches and researchers have identified genes regulating plasticity through a variety of mechanisms. Despite this effort, a great deal remains unknown regarding th...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22592
更新日期:2014-12-01 00:00:00
abstract::Three decades ago a series of parallel circuits were described involving the frontal cortex and deep grey matter structures, with putative roles in control of motor and oculomotor function, cognition, behaviour and emotion. The circuit comprising the dorsolateral prefrontal cortex, caudate, globus pallidus and thalamu...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25239
更新日期:2020-10-19 00:00:00
abstract::Non-verbal number sense has been shown to significantly correlate with arithmetic fluency. Accumulated behavioral evidence indicates that the cognitive mechanism relies on visual perception. However, few studies have investigated the neural mechanism underlying this association. Following the visual perception account...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25179
更新日期:2020-12-15 00:00:00