Abstract:
:We demonstrate that multivoxel pattern analysis can be used to decode place-related information in fMRI. Subjects performed a working memory version of the Morris water maze task in a virtual environment with a single wall cue. The voxel data that corresponds to when subjects were located at the goal was extracted for seven regions implicated in spatial navigation, and then used to train a pattern classifier based on partial least squares. Using a leave-one-out (LOO) test procedure, goal locations at E, W, N positions (relative to the cue as S) were predicted significantly better than a naïve classifier for voxels in medial prefrontal cortex, hippocampus, and inferior parietal cortex. Prediction with voxels from other regions involved in navigation was also better than a naïve classifier, which raises the possibility that goal-location information is widely disseminated among the navigation network. It turns out that predictive capability of all regions combined significantly decreases, relative to no change, only when voxel data from the hippocampus is left out. This implies that the hippocampus contains some unique information that identifies goal locations, whereas other regions contain information that also identifies goal locations but is more redundant. Classification of goal locations is an important step toward decoding a variety of place-related information in spatial navigation with fMRI.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Rodriguez PFdoi
10.1002/hbm.20873subject
Has Abstractpub_date
2010-03-01 00:00:00pages
391-7issue
3eissn
1065-9471issn
1097-0193journal_volume
31pub_type
杂志文章abstract::Neuroimaging studies in humans have consistently found robust activation of frontal, parietal, and temporal regions during working memory tasks. Whether these activations represent functional networks segregated by perceptual domain is still at issue. Two functional magnetic resonance imaging experiments were conducte...
journal_title:Human brain mapping
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1998-01-01 00:00:00
abstract::Research using the Stop Signal Task employing an adaptive algorithm to accommodate individual differences often report inferior performance on the task in individuals with ADHD, OCD, and substance use disorders compared to non-clinical controls. Furthermore, individuals with deficits in inhibitory control tend to show...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24075
更新日期:2018-08-01 00:00:00
abstract::Theoretical models of addiction suggest that a substance use disorder represents an imbalance between hypersensitive motivational processes and deficient regulatory executive functions. Working-memory (a central executive function) may be a powerful predictor of the course of drug use and drug-related problems. Goal o...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22342
更新日期:2014-05-01 00:00:00
abstract::Everyday communication is accompanied by visual information from several sources, including co-speech gestures, which provide semantic information listeners use to help disambiguate the speaker's message. Using fMRI, we examined how gestures influence neural activity in brain regions associated with processing semanti...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20774
更新日期:2009-11-01 00:00:00
abstract::There has been a recent call for longitudinal imaging studies to better characterize the time course of physiological recovery following sport-related concussion (SRC) and its relationship with clinical recovery. To address this, we evaluated changes to resting-state functional connectivity (rs-FC) of the whole-brain ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24440
更新日期:2019-03-01 00:00:00
abstract::Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF) and between-subject variation of Hct thus causes variation in task-based BOLD fMRI signal changes. We first verified in healthy volunteers (n = 12) that Hct values can be derived reliably from venous blood T1 values by compariso...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23846
更新日期:2018-01-01 00:00:00
abstract::Affective theory of mind (ToM) depends on both the decoding of emotional expressions and the reasoning on emotional mental states from social situations. While previous studies characterized the neural substrates underlying these processes, it remains unclear whether the nature of the emotional state inferred from oth...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24794
更新日期:2020-01-01 00:00:00
abstract::It has recently been demonstrated that specific patterns of correlation exist in diffusion tensor imaging (DTI) parameters across white matter tracts in the normal human brain. These microstructural correlations are thought to reflect phylogenetic and functional similarities between different axonal fiber pathways. Ho...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21292
更新日期:2012-06-01 00:00:00
abstract::Intermittent theta burst stimulation (iTBS) delivered to the dorsolateral prefrontal cortex (DLPFC) has been investigated as a promising treatment for stress and stress-related mental disorders such as major depression, yet large individual differences in responsiveness demand further exploration and optimization of i...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25193
更新日期:2020-12-15 00:00:00
abstract::Simultaneous electroencephalography and functional magnetic resonance imaging (EEG/fMRI) have been proposed to contribute to the definition of the epileptic seizure onset zone. Following interictal epileptiform discharges, one usually assumes a canonical hemodynamic response function (HRF), which has been derived from...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20925
更新日期:2010-08-01 00:00:00
abstract::There are two basic types of photoreceptors in the retina: rods and cones. Using a single stimulus viewed at two different light levels, we tested whether input from rods and input from cones are topographically segregated at subsequent levels of human visual cortex. Here we show that rod-mediated visual input produce...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To determine the functional connectivity of different EEG bands at the "baseline" situation (rest) and during mathematical thinking in children and young adults to study the maturation effect on brain networks at rest and during a cognitive task. METHODS:Twenty children (8-12 years) and twenty students (21-2...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20492
更新日期:2009-01-01 00:00:00
abstract::The development of treatments for attention impairments is hampered by limited knowledge about the malleability of underlying neural functions. We conducted the first randomized controlled trial to determine the modulations of brain activity associated with working memory (WM) training in adults with attention-deficit...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25164
更新日期:2020-12-01 00:00:00
abstract::Characterizing the neurovascular coupling between hemodynamic signals and their neural origins is crucial to functional neuroimaging research, even more so as new methods become available for integrating results from different functional neuroimaging modalities. We present a novel method to relate magnetoencephalograp...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20361
更新日期:2008-01-01 00:00:00
abstract::The nuclei of the human amygdala remain difficult to distinguish in individual subject structural magnetic resonance images. However, interpretation of the amygdala's role in whole brain networks requires accurate localization of functional activity to a particular nucleus or subgroup of nuclei. To address this, high ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23289
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:Early life trauma (ELT) is a significant risk factor for the onset of depression. Emerging findings indicate ELT is associated with enhanced amygdala reactivity to aversive stimuli in never-depressed healthy controls as well as those with acute depression but may be absent in non-ELT exposed depressed. The pr...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22514
更新日期:2014-09-01 00:00:00
abstract::Cognitive procedural learning occurs in three qualitatively different phases (cognitive, associative, and autonomous). At the beginning of this process, numerous cognitive functions are involved, subtended by distinct brain structures such as the prefrontal and parietal cortex and the cerebellum. As the learning progr...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20605
更新日期:2009-04-01 00:00:00
abstract::The framework of assimilation and accommodation has been proposed to explain the brain mechanisms supporting second language reading acquisition (Perfetti et al. [2007]: Bilingual Lang Cogn 10:131). Assimilation refers to using the procedures of the native language network in the acquisition of a new writing system, w...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22904
更新日期:2015-10-01 00:00:00
abstract::Positive number arithmetic is based on combining and separating sets of items, with systematic differences in brain activity in specific regions depending on operation. In contrast, arithmetic with negative numbers involves manipulating abstract values worth less than zero, possibly involving different operation-activ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22201
更新日期:2014-02-01 00:00:00
abstract::Advances in functional brain imaging have improved the search for potential endophenotypic markers in schizophrenia. Here, we employed independent component analysis (ICA) and dynamic causal modeling (DCM) in resting state fMRI on a sample of 35 schizophrenia patients, 20 first-degree relatives and 35 control subjects...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23477
更新日期:2017-04-01 00:00:00
abstract::We used computer simulations to investigate finite element models of the layered structure of the human skull in EEG source analysis. Local models, where each skull location was modeled differently, and global models, where the skull was assumed to be homogeneous, were compared to a reference model, in which spongy an...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21114
更新日期:2011-09-01 00:00:00
abstract::Estimates of visual field topographies in human visual cortex obtained through fMRI traveling wave techniques usually provide the parameters of population receptive field (pRF) location (polar angle, eccentricity) and receptive field size. These parameters are obtained by fitting the recorded data to a standard model ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24015
更新日期:2018-06-01 00:00:00
abstract::Magnetic resonance imaging of subcortical gray matter structures, which mediate behavior, cognition and the pathophysiology of several diseases, is crucial for establishing typical maturation patterns across the human lifespan. This single site study examines T1-weighted MPRAGE images of 3 healthy cohorts: (i) a cross...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23604
更新日期:2017-08-01 00:00:00
abstract::A face-selective neural signal is reliably found in humans with functional MRI and event-related potential (ERP) measures, which provide complementary information about the spatial and temporal properties of the neural response. However, because most neuroimaging studies so far have studied ERP and fMRI face-selective...
journal_title:Human brain mapping
pub_type: 杂志文章,随机对照试验
doi:10.1002/hbm.20952
更新日期:2010-10-01 00:00:00
abstract::Recognition of objects and their relations is necessary for orienting in real life. We examined cognitive processes related to recognition of objects, their relations, and the patterns they form by using the game of chess. Chess enables us to compare experts with novices and thus gain insight in the nature of developm...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21396
更新日期:2012-11-01 00:00:00
abstract::Standard procedures to achieve quality assessment (QA) of functional magnetic resonance imaging (fMRI) data are of great importance. A standardized and fully automated procedure for QA is presented that allows for classification of data quality and the detection of artifacts by inspecting temporal variations. The appl...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20096
更新日期:2005-06-01 00:00:00
abstract::Playing music requires a strong coupling of perception and action mediated by multimodal integration of brain regions, which can be described as network connections measured by anatomical and functional correlations between regions. However, the structural and functional connectivities within and between the auditory ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23989
更新日期:2018-05-01 00:00:00
abstract::Surprise drives learning. Various neural "prediction error" signals are believed to underpin surprise-based reinforcement learning. Here, we report a surprise signal that reflects reinforcement learning but is neither un/signed reward prediction error (RPE) nor un/signed state prediction error (SPE). To exclude these ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22513
更新日期:2014-09-01 00:00:00
abstract::Many studies have shown the involvement of the premotor cortex in action observation, recognizing this region as the neural marker of action simulation (i.e., internal modeling on the basis of the observer's own motor repertoire). So far, however, we have remained unaware of how action simulation differs from more gen...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20949
更新日期:2011-05-01 00:00:00
abstract::In functional magnetic resonance imaging (fMRI) research one is typically interested in neural activity. However, the blood-oxygenation level-dependent (BOLD) signal is a composite of both neural and vascular activity. As factors such as age or medication may alter vascular function, it is essential to account for cha...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22768
更新日期:2015-06-01 00:00:00