Abstract:
:Essentially all social species experience social stress which can be a catalyst for detriments in mental and physical health. The neuropeptide oxytocin (OXT) has been shown to produce anxiolytic and antistress effects, thereby qualifying the OXT system as a promising drug target in the treatment of stress-related disorders. However, recently it has been shown that OXT can have anxiogenic effects as well. In the present study, we used functional magnetic resonance imaging to scan the brains of 60 healthy men while they were exposed to social stress after they received either intranasal OXT (24 IU) or placebo treatment. Although OXT administration did not alter salivary cortisol levels as a surrogate marker of stress axis activity, our participants initially reported an increment in perceived social stress. This behavioral effect was paralleled on the neural level by increased activity in the precuneus and cingulate cortex. Taken together, our results support the hypothesis that OXT can induce a self-referential processing bias which facilitates the sensation of social stress in the absence of altered endocrine responses.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Eckstein M,Scheele D,Weber K,Stoffel-Wagner B,Maier W,Hurlemann Rdoi
10.1002/hbm.22508subject
Has Abstractpub_date
2014-09-01 00:00:00pages
4741-50issue
9eissn
1065-9471issn
1097-0193journal_volume
35pub_type
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journal_title:Human brain mapping
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